Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	FLCN	Unknown	29937994 29316426 28546418 25957691 26109429 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLI1	Unknown	26071483 29937994 26416732 26336987 25957691 25344691 29844865 24755471 22895193	Open Targets	Transcriptional misregulation in cancer
		FLNA	Unknown	22810696 30038269 27612425 29937994 26336987 25957691 26109429 30239619 32375028 25344691 24755471 22895193	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT3	Unknown	22810696 34680263 26071483 29665843 25617745 29937994 26416732 27756406 23856246 25957691 30239619 25344691 38725616 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	22810696 18186519 29967250 26071483 29665843 26764183 27612425 29937994 26416732 29316426 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FNBP1	Unknown	22810696 26764183 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXA1	Unknown	28481359 24755471 29316426 25344691 25957691	Open Targets	Estrogen-dependent gene expression
		FOXL2	Unknown	29937994 26416732 29316426 25589621 32375028 25344691 29844865 28481359	Open Targets	SUMOylation of transcription factors
		FOXO1	Unknown	22810696 26071483 29937994 29316426 25957691 25344691 29844865 22895193 28481359	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		FOXO3	Unknown	24755471 30239619 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXO4	Unknown	22810696 26416732 22895193 25957691 38725616	Open Targets	Ras signaling pathway FoxO signaling pathway Shigellosis +7 more
		FOXP1	Unknown	22810696 29967250 26071483 29937994 25957691 30239619 25344691 29844865 24755471 22895193 28481359	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FOXR1	Unknown	25957691 22895193 25344691	Open Targets	—
		FSTL3	Unknown	38725616 26416732 22895193	Open Targets	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		FUBP1	Unknown	22810696 29937994 27245685 25957691 25344691 22895193 28481359	Open Targets	—
		FUS	Unknown	26416732 28546418 25957691 25344691 31336886 24755471 22895193 38725616	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GAS7	Unknown	22810696 26071483 25957691 30239619 25344691 22895193	Open Targets	—
		GATA1	Unknown	22810696 26071483 26416732 29316426 27245685 28546418 25344691 29844865 22895193 28481359	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	22810696 26071483 29665843 26764183 26336987 25957691 26109429 32375028 25344691 29844865 22895193 28481359	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA3	Unknown	22810696 29967250 29937994 26416732 26336987 28145097 25957691 25344691 38725616 24755471 27566247 22895193 28481359	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	22810696 30038269 29937994 26416732 29316426 25957691 30239619 25344691 24755471 22895193 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	22810696 29937994 26336987 25957691 26109429 32375028 25344691	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNA11	Unknown	29937994 29316426 27756406 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAQ	Unknown	22810696 27023146 26071483 26416732 26336987 27756406 25957691 29316426 32375028 28481359	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	30038269 26416732 28120820 24755471 32561076 22810696 29967250 23856246 27154293 16959974 25695693 29844865 38725616 24498230 27566247 26071483 27302369 29937994 26336987 27756406 25957691 25344691 26968814 22895193 24470207 30239619 23471846 28481359	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	30038269 29937994 23856246 25957691 25344691 24755471 22895193	Open Targets	Intra-Golgi traffic
		GOLPH3	Unknown	22810696 26416732 22895193 29937994	Open Targets	—
		GOPC	Unknown	26071483 25957691 30239619 25344691 38725616 31336886	Open Targets	RHO GTPases regulate CFTR trafficking
		GPC3	Unknown	32375028 26416732 22895193 25344691 25957691	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	22810696 29937994 26416732 26336987 25957691 25344691 24755471 22895193	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	22810696 27612425 29937994 26416732 25957691 26109429 25344691 24755471 22895193	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	22810696 29967250 26071483 26764183 29937994 27612425 21203531 26416732 29316426 23856246 28465371 25957691 26336987 30239619 32375028 25344691 22895193 28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	22810696 26071483 27612425 29937994 21203531 26416732 32375028 25344691 24755471 22895193	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	22810696 23856246 25957691 25344691 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		GTF2I	Unknown	25957691 24755471 26071483 25344691	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		H3-3A	Unknown	23758177 24943349 28481359	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3-3B	Unknown	25957691 24755471 22895193 25344691 22810696	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3C2	Unknown	28481359 26416732 22895193 25589621 25957691	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		H4C9	Unknown	22895193 29937994	Open Targets	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HERPUD1	Unknown	22810696 26071483 29937994 25957691 25344691 24755471 22895193	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HGF	Unknown	22810696 29967250 26071483 26764183 26416732 29316426 25957691 26109429 25344691 38725616 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	29967250 29937994 26416732 23856246 25344691 29844865 24755471 22895193	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HIP1	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 30239619 32375028 25344691 38725616 24755471 22895193	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLA-A	Unknown	22810696 27302369 29316426 26109429 25344691 28481359	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HLF	Unknown	22810696 26071483 24943349 25957691 25344691 24755471 22895193	Open Targets	—
		HMGA1	Unknown	30239619	Open Targets	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA +4 more
		HMGA2	Unknown	22810696 30239619 26071483 25957691 29937994	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HNF1A	Unknown	22810696 26071483 29937994 26416732 27756406 25957691 19503063 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Maturity onset diabetes of the young
		HNRNPA2B1	Unknown	22810696 29937994 26416732 25957691 25344691 31336886 22895193	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HOOK3	Unknown	22810696 29967250 26071483 29937994 26416732 23856246 25957691 32375028 25344691 24755471 22895193	Open Targets	Motor proteins

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Colon adenocarcinoma

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