Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	EPAS1	Unknown	22810696 26071483 29937994 23856246 25957691 26109429 25344691 24755471 22895193	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	22810696 29967250 26071483 29937994 26416732 29316426 23856246 25957691 26109429 30239619 25344691 29844865 16959974 24755471 22895193 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	22810696 26071483 26764183 29937994 26416732 29316426 25957691 30239619 16959974 25344691 29844865 24755471 22895193 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	22810696 26071483 29937994 25957691 25344691 24755471	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	18186519 34680263 27004155 26071483 22810696 24755471 26764183 29937994 29665843 26416732 29316426 27756406 25957691 28145097 28978093 30239619 25344691 29844865 25617745 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	29665843 26416732 29316426 24755471 18186519 22810696 29967250 29844865 38725616 29420467 29937994 25957691 25344691 26764183 22895193 22014273 23680147 28978093 30239619 32375028 36142641 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	16187281 29665843 27612425 26416732 29316426 24755471 18186519 30962964 22810696 29967250 23856246 27245685 28145097 26109429 29844865 25623536 26071483 29937994 26336987 27756406 25957691 25344691 26764183 22895193 27023146 30239619 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	22810696 26071483 26764183 29937994 21203531 26336987 25957691 25344691 31336886 24755471 22895193	Open Targets	NF-kappa B signaling pathway
		ERCC3	Unknown	22810696 29967250 26764183 29937994 29316426 23856246 25344691 29844865 22895193 28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	26764183 29937994 26416732 29316426 25344691 29844865 22895193 28481359	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	22810696 26764183 29937994 26336987 29316426 25957691 26109429 30239619 25344691 29844865 38725616 22895193 28481359	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	22810696 26764183 29937994 21203531 26416732 29316426 26336987 25957691 17367471 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	22810696 24943349 26071483 27302369 29937994 26416732 26336987 29316426 25957691 26109429 30239619 25344691 29844865 24755471 22895193 28481359	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	26416732 22895193 25344691 29937994	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV1	Unknown	22810696 26071483 26416732 29316426 26109429 17367471 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer
		ETV4	Unknown	22810696 26071483 29937994 21203531 23856246 25957691 25344691 29844865 24755471	Open Targets	Transcriptional misregulation in cancer MAPK6/MAPK4 signaling
		ETV5	Unknown	22810696 29967250 24943349 29937994 26336987 23856246 25957691 30239619 25344691 22895193	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV6	Unknown	22810696 30038269 26416732 29316426 25957691 25344691 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	29937994 26416732 26336987 25957691 25344691 38725616 24755471 22895193	Open Targets	Transcriptional misregulation in cancer
		EXT2	Unknown	32375028 22895193 25344691 29844865 29937994	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EZH2	Unknown	22810696 29967250 31400926 29937994 26416732 29316426 25957691 25344691 16959974 22895193 28481359	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	24755471 26416732 22895193 25344691 25957691	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FADD	Unknown	26764183 25957691	Open Targets	Platinum drug resistance Apoptosis Apoptosis - multiple species +36 more
		FAM131B	Unknown	22810696 24755471 22895193 25344691 29937994	Open Targets	Signaling by BRAF and RAF fusions
		FAM135B	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 30239619 25344691 31336886 24755471 22895193	Open Targets	—
		FAM47C	Unknown	22810696 30038269 29937994 26416732 25957691 32375028 25344691 38725616 22895193	Open Targets	—
		FANCA	Unknown	22810696 26071483 26764183 29937994 26416732 29316426 23856246 25957691 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCE	Unknown	26336987 25344691	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	22810696 24755471 25957691 29937994	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 25957691 16959974 25344691 22895193	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAS	Unknown	25957691 26764183 25344691 29844865	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	22810696 30038269 34680263 26071483 26764183 29937994 26416732 26336987 23354438 25957691 29316426 28145097 26109429 30239619 32375028 25344691 24755471 22895193 28481359 28551381	Open Targets	—
		FAT3	Unknown	22810696 30038269 26071483 27612425 29937994 26416732 26336987 25957691 26109429 25344691 31336886 24755471 22895193 38725616	Open Targets	—
		FAT4	Unknown	22810696 30038269 26071483 38725616 27612425 29937994 26416732 26336987 23856246 25957691 28145097 30239619 25344691 31336886 24755471 22895193 28551381	Open Targets	Hippo signaling pathway - multiple species
		FBLN2	Unknown	30038269 26071483 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	Cytoskeleton in muscle cells Molecules associated with elastic fibres
		FBXO11	Unknown	27612425 26416732 29316426 24755471 22810696 29967250 23856246 25194673 26109429 29844865 38725616 31400926 26071483 29937994 26336987 25957691 20565851 32664968 25344691 22895193 27023146 30387329 28481359	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	30036146 26650777 19420964 28243320 26416732 29316426 28120820 24755471 21726664 29967250 22810696 17909001 23856246 28145097 27245685 26109429 16959974 29844865 25623536 17274947 25695693 31336886 31400926 26071483 27302369 29937994 26336987 27756406 25957691 25344691 22895193 26764183 28978093 30239619 25617745 28481359 31226844	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCGR2B	Unknown	22810696	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FCRL4	Unknown	29937994 26336987 23856246 25957691 30239619 25344691 24755471 22895193	Open Targets	—
		FEN1	Unknown	22810696 25344691	Open Targets	DNA replication Base excision repair Non-homologous end-joining +6 more
		FES	Unknown	24755471 26416732 22895193 25344691 29937994	Open Targets	Axon guidance Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion +1 more
		FEV	Unknown	25957691 24755471 26071483 25344691	Open Targets	Transcriptional misregulation in cancer
		FGFR1	Unknown	22810696 29665843 25617745 29937994 26416732 29316426 25589621 25957691 26109429 30239619 25344691 29844865 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	29967250 34680263 24755471 26071483 29665843 29937994 21203531 27756406 28465371 22014273 25344691 29844865 38725616 25617745 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	22810696 34680263 26071483 29665843 29937994 26416732 26336987 27756406 25957691 29316426 25589621 30239619 25344691 29844865 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FGFR4	Unknown	22810696 29665843 26764183 29937994 26416732 29316426 25957691 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FH	Unknown	28481359 26416732 22895193 25344691 29937994	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FHIT	Unknown	22810696 26336987 25957691	Open Targets	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FIP1L1	Unknown	22810696 26764183 29937994 26416732 23856246 25957691 25344691 38725616 24755471 22895193 28481359	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FKBP9	Unknown	22810696 22895193 25344691 38725616	Open Targets	—

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Colon adenocarcinoma

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