Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	POLQ	Unknown	22810696 30038269 29937994 26416732 23856246 25957691 30239619 32375028 25344691 38725616 24755471 22895193	Open Targets	HDR through MMEJ (alt-NHEJ)
		POLR2A	Unknown	22810696 29937994 26336987 25957691 25344691 31336886 24755471	Open Targets	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		POT1	Unknown	22810696 26071483 29937994 23856246 25957691 26109429 25344691 24755471	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		POU2AF1	Unknown	21203531 24755471 26071483 28546418	Open Targets	—
		POU5F1	Unknown	25957691 24755471 25344691 38725616	Open Targets	Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation +1 more
		PPARG	Unknown	29967250 25344691 29844865 29937994	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPFIBP1	Unknown	22810696 29937994 26416732 26336987 25957691 30239619 25344691	Open Targets	Receptor-type tyrosine-protein phosphatases
		PPM1D	Unknown	22810696 26071483 26764183 29937994 23856246 25344691 24755471 22895193 28481359	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP6C	Unknown	22810696 28481359 22895193 25344691 29937994	Open Targets	COPII-mediated vesicle transport
		PRCC	Unknown	21203531 24755471 22895193 25344691	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	22810696 26071483 29937994 26416732 25957691 25344691 24755471 22895193 28481359	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	22810696 26071483 29937994 25957691 30239619 25344691 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	22810696 29937994 26416732 26336987 23856246 25957691 30239619 25344691 38725616 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	22810696 26071483 26764183 27612425 29937994 26416732 29316426 23856246 25957691 28145097 26109429 32375028 16959974 25344691 38725616 24755471 22895193	Open Targets	Regulation of PTEN stability and activity
		PRF1	Unknown	22810696 30038269 26071483 29937994 25344691 24755471 22895193	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRKACA	Unknown	25957691 24755471 22895193 25344691 29937994	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKAR1A	Unknown	22810696 29937994 29316426 23856246 25957691 25344691 28481359	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	22810696 26071483 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	22810696 26071483 29937994 26416732 29316426 23856246 25957691 30239619 16959974 25344691 24755471 22895193	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRPF40B	Unknown	22810696 29937994 25957691 25344691 38725616 24755471 22895193	Open Targets	Spliceosome
		PRRX1	Unknown	22810696 26071483 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	—
		PSIP1	Unknown	26071483 29937994 23856246 25957691 25344691 29844865 24755471	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	22810696 29967250 24755471 26071483 27023146 29665843 26764183 29937994 26416732 26336987 29316426 25957691 26109429 30239619 25344691 29844865 9192811 22895193 29420467 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTK6	Unknown	25957691 22895193 25344691	Open Targets	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling +8 more
		PTPN11	Unknown	30038269 24699064 29937994 26416732 29316426 23856246 27756406 26109429 15604238 25344691 24755471 22895193 28481359 31226844	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	22810696 26071483 29937994 27612425 26416732 25957691 32375028 25344691 38725616 24755471 22895193	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPN6	Unknown	26071483 27612425 26416732 26336987 25957691 25344691 24755471 22895193	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRB	Unknown	26071483 29937994 26416732 26336987 25957691 30239619 25344691 38725616 24755471 22895193	Open Targets	Adherens junction Neutrophil degranulation
		PTPRC	Unknown	22810696 26071483 24943349 29937994 26416732 26336987 25957691 25344691 22895193	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 26336987 29316426 25957691 32375028 25344691 16959974 29844865 31336886 24755471 22895193 28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	22810696 26071483 29937994 26416732 23856246 25957691 25344691 38725616 24755471 22895193	Open Targets	EGFR downregulation
		PTPRT	Unknown	22810696 29967250 26071483 24943349 29665843 26764183 29937994 26416732 29316426 23856246 25957691 17223850 25589621 26109429 30239619 25344691 29844865 31336886 24755471 22895193 28481359	Open Targets	—
		PWWP2A	Unknown	24755471 22895193 25344691	Open Targets	—
		QKI	Unknown	22810696 29937994 27612425 23856246 25957691 28546418 30239619 16959974 25344691 24755471 22895193	Open Targets	Signaling by BRAF and RAF fusions
		RABEP1	Unknown	22810696 29937994 25957691 26109429 25344691 22895193	Open Targets	Endocytosis TBC/RABGAPs
		RAC1	Unknown	34680263 25957691 30475948 30239619 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +89 more
		RAD17	Unknown	22810696 29937994 25957691 30239619 25344691 22895193	Open Targets	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends +3 more
		RAD21	Unknown	26071483 26416732 26336987 23856246 29316426 25344691 38725616 24755471 22895193 28481359	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD50	Unknown	22810696 26764183 29937994 26416732 29316426 23856246 25957691 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51	Unknown	25957691 24755471 25344691 29937994 28481359	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +8 more
		RAD51B	Unknown	22810696 26071483 25589621 25957691 25344691 24755471 22895193 28481359	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	28481359 26416732 22895193 25344691 25957691	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAD51D	Unknown	22810696 26416732 25957691 32375028 25344691 28481359	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAF1	Unknown	22810696 26071483 29937994 23856246 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RALGDS	Unknown	29937994 25957691 16959974 25344691 29844865 38725616 24755471 22895193	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RANBP2	Unknown	22810696 26764183 29937994 26416732 26336987 23856246 25957691 25344691 38725616 24755471 22895193	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1B	Unknown	22810696 25344691 25957691	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +25 more
		RAP1GDS1	Unknown	22810696 29937994 26109429 38725616 24755471 22895193	Open Targets	—
		RARA	Unknown	22810696 29937994 26416732 29316426 25957691 25344691 29844865 24755471 26764183 28481359	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	22810696 29937994 26416732 26336987 29316426 25957691 26109429 25344691 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more

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Colon adenocarcinoma

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