Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	NRG1	Unknown	22810696 26071483 26764183 27612425 29937994 26416732 26336987 25957691 26109429 30239619 25344691 38725616 24755471 22895193	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	22810696 29937994 26416732 23856246 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD2	Unknown	22810696 29937994 26416732 26336987 23856246 25957691 25344691 29844865 38725616 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NSD3	Unknown	26071483 29937994 26336987 25957691 25344691 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NT5C2	Unknown	22810696 29937994 27612425 25957691 25344691 24755471 22895193	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTHL1	Unknown	22895193 25344691 25957691	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		NTRK1	Unknown	22810696 29967250 30038269 26071483 26764183 29937994 2869410 26416732 25957691 25344691 29844865 31336886 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	22810696 27612425 29937994 26336987 29316426 25957691 26109429 30239619 25344691 38725616 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	22810696 29967250 26071483 29665843 26764183 29937994 26416732 29316426 28465371 25957691 26109429 30239619 25344691 29844865 31336886 24755471 22895193 28481359 38725616	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	22810696 26071483 29937994 21203531 26336987 23856246 25957691 30239619 25344691 29844865 38725616 24755471 22895193	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	22810696 29967250 21203531 23856246 25957691 26109429 30239619 25344691 29844865 38725616 24755471 22895193	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	22810696 26071483 26764183 29937994 26416732 25957691 26109429 30239619 32375028 25344691 29844865 31336886 24755471 22895193 38725616	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM1	Unknown	22810696 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	—
		NUTM2D	Unknown	22810696 25344691 25957691	Open Targets	—
		OLIG2	Unknown	30239619 22895193 25344691 25957691 26416732	Open Targets	—
		OMD	Unknown	25344691 29937994	Open Targets	Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 +2 more
		P2RY8	Unknown	22810696 30239619 25344691 25957691	Open Targets	Neuroactive ligand-receptor interaction
		PABPC1	Unknown	22810696 22895193 25957691 26109429 30239619 25344691 24699064	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAFAH1B2	Unknown	22895193 25344691	Open Targets	Ether lipid metabolism Metabolic pathways Neutrophil degranulation +1 more
		PALB2	Unknown	22810696 30038269 26071483 29937994 26416732 29316426 25957691 25344691 29844865 22895193 28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PATZ1	Unknown	22810696 24755471 30239619 25344691 29937994	Open Targets	—
		PAX3	Unknown	22810696 26071483 27612425 29937994 26416732 25957691 30239619 25344691 29844865 31336886 22895193	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	26071483 26764183 29937994 26416732 29316426 26336987 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	29967250 29937994 23856246 25957691 26109429 30239619 25344691 29844865 22895193	Open Targets	Transcriptional misregulation in cancer
		PAX8	Unknown	27612425 25957691 32375028 25344691 29844865 24755471 22895193	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PBRM1	Unknown	22810696 29937994 26416732 29316426 23856246 25957691 30239619 32375028 25344691 38725616 24755471 27566247 22895193 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	22810696 29937994 26416732 25344691 29844865 22895193	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCBP1	Unknown	22810696 30038269 26071483 26416732 26336987 25957691 30239619 25344691 22895193	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PCM1	Unknown	22810696 26071483 29937994 25957691 26109429 32375028 25344691 31336886 24755471 22895193	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDCD1LG2	Unknown	29937994	Open Targets	Cell adhesion molecules PD-1 signaling
		PDE4DIP	Unknown	22810696 26071483 29937994 26416732 26336987 25957691 26109429 30239619 25344691 29844865 22895193	Open Targets	—
		PDGFB	Unknown	22810696 26071483 28546418 30239619 25344691 24755471 22895193	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PDGFRA	Unknown	22810696 34680263 26071483 29665843 29937994 26416732 26336987 27756406 25957691 28145097 29316426 25344691 25617745 22895193 29420467 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	22810696 26071483 29937994 26416732 23856246 25957691 32375028 25344691 29844865 24755471 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PER1	Unknown	22810696 26071483 26764183 29937994 26336987 25957691 25344691 16959974 29844865 24755471 22895193	Open Targets	Circadian rhythm Circadian entrainment
		PHF6	Unknown	30239619 26071483 22895193	Open Targets	ATP-dependent chromatin remodeling
		PHOX2B	Unknown	22810696 29967250 26071483 29937994 29316426 25957691 25344691 29844865 38725616 22895193 28481359	Open Targets	—
		PICALM	Unknown	24755471 26416732 23856246 25957691 29937994	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIK3CB	Unknown	29937994 26416732 30631260 23856246 25957691 26336987 29316426 25344691 24755471 22895193 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R2	Unknown	29967250 26071483 29937994 26336987 25957691 25344691 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PIK3R3	Unknown	26416732 22895193 28481359 29937994	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PIM1	Unknown	24755471 26071483 25344691 28481359 29844865	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		PLAG1	Unknown	22810696 26071483 29937994 26416732 26336987 25957691 25344691 22895193	Open Targets	—
		PLCG1	Unknown	22810696 29937994 26416732 26336987 25344691 29844865 24755471 22895193	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	22810696 26071483 26764183 29937994 26416732 26336987 23856246 25957691 26109429 32375028 25344691 38725616 24755471 22895193 17932254	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	22810696 30038269 26071483 24943349 26764183 29937994 26416732 26336987 23856246 25957691 30239619 25344691 29844865 31336886 24755471 22895193	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS1	Unknown	22810696 29937994 26416732 26336987 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	—
		POLD1	Unknown	22810696 29937994 26416732 26336987 23856246 10074927 25957691 29316426 26109429 25344691 24755471 22895193 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	27612425 26416732 29316426 24755471 22810696 29967250 23856246 28145097 25194673 28188185 29998005 38725616 26071483 29937994 26336987 25957691 28465371 24525744 32664968 25344691 33727829 22895193 26764183 29072370 27022117 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLG	Unknown	22810696 29937994 25957691 26109429 30239619 25344691 38725616 24755471 22895193	Open Targets	Base excision repair

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Colon adenocarcinoma

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