Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
cecum adenocarcinoma	MONDO_0006028	NSD2	Unknown	22810696 25344691 29844865	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NSD3	Unknown	25344691	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NT5C2	Unknown	22810696 26336987 25344691	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTHL1	Unknown	26336987	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		NTRK1	Unknown	22810696 26336987 29316426 30239619 25344691 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	22810696 29316426 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	22810696 28481359	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	25344691 29844865	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	25344691	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	29844865	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM1	Unknown	22810696 25344691	Open Targets	—
		NUTM2D	Unknown	22810696	Open Targets	—
		P2RY8	Unknown	22810696 25344691 38725616	Open Targets	Neuroactive ligand-receptor interaction
		PABPC1	Unknown	30239619 25344691	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PALB2	Unknown	22810696 25344691 28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PATZ1	Unknown	22810696 25344691	Open Targets	—
		PAX5	Unknown	28481359 29316426 25344691	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX8	Unknown	38725616 29844865	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PBRM1	Unknown	22810696 29316426 25344691 28481359 29844865	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	22810696 25344691 29844865	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCBP1	Unknown	26764183 25344691	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PCM1	Unknown	22810696 26336987 27612425	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDE4DIP	Unknown	22810696 25344691	Open Targets	—
		PDGFB	Unknown	22810696 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PDGFRA	Unknown	22810696 25344691 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	29316426 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PER1	Unknown	25344691 29844865	Open Targets	Circadian rhythm Circadian entrainment
		PHOX2B	Unknown	28481359 25344691	Open Targets	—
		PIK3CA	Unknown	22810696 26650777 29967250 27612425 29316426 28218421 25344691 29844865 23471846 38725616 26764183 28481359 28551381	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	29316426 26336987 25344691 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	22810696 29316426 25344691 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIK3R2	Unknown	22810696 25344691 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PIK3R3	Unknown	28481359 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PIM1	Unknown	28481359 25344691	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		PLAG1	Unknown	22810696	Open Targets	—
		PLEC	Unknown	38725616 26336987 25344691	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	22810696 26336987 25344691 29844865	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS1	Unknown	22810696 28481359 29316426 25344691	Open Targets	—
		PMS2	Unknown	28481359 29316426 28978093 25344691	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	22810696 29316426 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	22810696 27612425 26336987 29072370 29316426 28218421 29998005 27022117 25344691 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLG	Unknown	25344691	Open Targets	Base excision repair
		POLQ	Unknown	25344691	Open Targets	HDR through MMEJ (alt-NHEJ)
		POU2AF1	Unknown	25344691	Open Targets	—
		PPARG	Unknown	25344691	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPM1D	Unknown	38725616 25344691 28481359	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	29316426 25344691 28481359	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	28481359 25344691	Open Targets	COPII-mediated vesicle transport
		PRCC	Unknown	30239619 25344691	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	22810696 28481359 38725616	Open Targets	Regulation of TP53 Expression

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Cecum adenocarcinoma

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