Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
cecum adenocarcinoma	MONDO_0006028	KIT	Unknown	22810696 28481359 25344691	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KLF4	Unknown	22810696 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLK2	Unknown	22810696	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	29316426 26336987 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	22810696 26336987 29316426 30239619 25344691 29844865 38725616 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	22810696 29316426 26336987 25344691 29844865 38725616 26764183 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	22810696 26336987 25344691	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KNSTRN	Unknown	22810696	Open Targets	—
		KRAS	Unknown	26650777 30038269 24018598 7890240 21704278 29316426 18603853 22810696 29967250 10025877 22722830 1627381 12093899 21369707 28218421 1453686 8421601 16959974 21665177 8621253 25623536 29844865 27566247 31400926 9834286 21901162 19679059 19527492 16077965 14633673 25344691 7731696 26764183 25248721 17150185 28551381 19026650 12524418 24470207 37113399 20924129 29072370 9018769 23393166 28978093 28548127 15674332 30239619 9328563 23471846 31900123 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	22810696	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	38725616	Open Targets	—
		LATS1	Unknown	22810696 29316426 28481359 38725616	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	25344691	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	22810696	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LHFPL6	Unknown	22810696 30239619	Open Targets	—
		LIFR	Unknown	22810696 25344691	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LMO1	Unknown	28481359	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		LOC100506403	Unknown	28481359 30239619 29316426 25344691	Open Targets	—
		LOC105376156	Unknown	22810696 29316426 25344691 28481359	Open Targets	—
		LOC124905021	Unknown	29316426 28481359 17367471	Open Targets	—
		LPP	Unknown	22810696 25344691	Open Targets	—
		LRIG3	Unknown	25344691	Open Targets	—
		LRP1B	Unknown	22810696 30239619 26336987 25344691 29844865	Open Targets	—
		LSM14A	Unknown	25344691	Open Targets	—
		LYN	Unknown	22810696	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		LZTR1	Unknown	31900123	Open Targets	—
		MACC1	Unknown	38725616	Open Targets	—
		MAF	Unknown	22810696 25344691	Open Targets	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MAFB	Unknown	25344691	Open Targets	Parathyroid hormone synthesis, secretion and action
		MALT1	Unknown	22810696 28481359 25344691	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		MAML2	Unknown	22810696 26336987 25344691	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	28481359 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K2	Unknown	28481359 29316426 25344691 29844865	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP2K4	Unknown	22810696 25344691 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	26336987 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	22810696 26336987 28481359	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	22810696 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAX	Unknown	22810696 28481359	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MB21D2	Unknown	25344691	Open Targets	—
		MDM2	Unknown	22810696 29316426	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MDM4	Unknown	22810696 28481359	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MECOM	Unknown	22810696	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	22810696 29967250 26336987 29316426 25344691 28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	22810696 28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	22810696 29316426 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MGMT	Unknown	30239619 31900123	Open Targets	MGMT-mediated DNA damage reversal
		MITF	Unknown	28481359	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLH1	Unknown	27612425 28978093 25344691 25370038 28306219 28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	22810696	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more

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Cecum adenocarcinoma

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