Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
cecum adenocarcinoma	MONDO_0006028	RNF43	Unknown	29967250 29316426 26336987 28548127 25344691 28481359	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	22810696 25344691	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	22810696 25344691	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		ROS1	Unknown	22810696 29967250 26336987 29316426 25344691 29844865 28481359	Open Targets	—
		RPL22	Unknown	25344691	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPL5	Unknown	25344691	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RUNX1T1	Unknown	22810696 26336987 25344691	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		RXRA	Unknown	25344691	Open Targets	PPAR signaling pathway Efferocytosis PI3K-Akt signaling pathway +39 more
		SALL4	Unknown	26336987	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SBDS	Unknown	25344691	Open Targets	Ribosome biogenesis in eukaryotes
		SDHA	Unknown	22810696 28481359 29316426 25344691	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHD	Unknown	22810696 28481359 25344691	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SEPTIN5	Unknown	22810696	Open Targets	Parkinson disease Pathways of neurodegeneration - multiple diseases
		SEPTIN6	Unknown	25344691	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SEPTIN9	Unknown	29967250	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETBP1	Unknown	22810696 30038269 30239619 26764183 25344691	Open Targets	—
		SETD2	Unknown	22810696 30038269 29316426 25344691 29844865 38725616 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	22810696 25344691	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SF3B1	Unknown	22810696 28481359 29316426 25344691	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFPQ	Unknown	22810696 38725616 27612425	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SFRP4	Unknown	25344691	Open Targets	Wnt signaling pathway
		SGK1	Unknown	22810696	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH2B3	Unknown	28481359	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SHTN1	Unknown	22810696 25344691	Open Targets	—
		SIRPA	Unknown	22810696 26336987 25344691	Open Targets	Efferocytosis Osteoclast differentiation Cell surface interactions at the vascular wall +2 more
		SIX1	Unknown	25344691	Open Targets	Transcriptional misregulation in cancer
		SIX2	Unknown	22810696	Open Targets	—
		SLC34A2	Unknown	26336987 25344691	Open Targets	Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters +2 more
		SLC45A3	Unknown	25344691	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Cellular hexose transport
		SMAD2	Unknown	22810696 29967250 29316426 28978093 25344691 38725616 28481359 28551381	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	29967250 29316426 28481359	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	22810696 26650777 30038269 31400926 29316426 19527492 30239619 25344691 25623536 27566247 26764183 28481359 28551381	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	29316426 28481359 11085541	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	28481359 25344691	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMARCD1	Unknown	28481359 25344691	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMARCE1	Unknown	22810696	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMO	Unknown	28481359 30239619 25344691	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SND1	Unknown	22810696 25344691 38725616	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SNX29	Unknown	22810696	Open Targets	—
		SOCS1	Unknown	28481359 25344691	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	22810696 29316426 28481359	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPECC1	Unknown	22810696 26336987 25344691	Open Targets	—
		SPEN	Unknown	22810696 28481359 30239619 29316426 25344691	Open Targets	Notch signaling pathway
		SPOP	Unknown	28481359 25344691	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	28481359 29316426 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SRGAP3	Unknown	22810696 25344691 38725616	Open Targets	Axon guidance Rho GTPase cycle
		SRSF3	Unknown	22810696	Open Targets	Spliceosome Amyotrophic lateral sclerosis Herpes simplex virus 1 infection +4 more
		SS18	Unknown	25344691	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAG1	Unknown	22810696 25344691	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more

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Cecum adenocarcinoma

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