Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	MONDO_0004985 C0005586 MONDO:0004985 MESH:D001714	STXBP4	Unknown	31043756	GWAS catalog	—
		SUFU	Unknown	33479212	GWAS catalog	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SUMF1	Unknown	18711365 20351715	GWAS catalog	Lysosome Glycosphingolipid metabolism The activation of arylsulfatases
		SVEP1	Unknown	18711365 20351715	GWAS catalog	—
		SYBU	Unknown	31043756	GWAS catalog	—
		SYN3	Unknown	—	Disgenet	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
		SYNDIG1	Unknown	20889312	GWAS catalog	—
		SYNE1	Unknown	18711365 20351715 21738484 21926972 23453885 28072414 28115744 31043756 34002096 38858783	Disgenet, GWAS catalog	Cytoskeleton in muscle cells
		SYNE2	Unknown	31835028 31926635	GWAS catalog	Cytoskeleton in muscle cells
		SYNGR1	Unknown	—	Disgenet, GenCC	Neutrophil degranulation
		SYT6	Unknown	20889312	GWAS catalog	—
		TAAR6	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Amine ligand-binding receptors G alpha (s) signalling events +1 more
		TAC1	Unknown	15845098	CTD, Disgenet	Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events
		TACR1	Unknown	19204064 34099189	CTD, Disgenet, GWAS catalog	Calcium signaling pathway Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins +3 more
		TAFA5	Unknown	24322204	GWAS catalog	—
		TAOK2	Unknown	33479212	GWAS catalog	MAPK signaling pathway
		TARS1	Unknown	30217971	GWAS catalog	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		TBC1D21	Unknown	34002096	GWAS catalog	—
		TBCC	Unknown	17554300	GWAS catalog	—
		TCAIM	Unknown	31835028 31926635	GWAS catalog	—
		TCF15	Unknown	23453885	GWAS catalog	—
		TCF20	Unknown	20889312 31835028 32606422	GWAS catalog	—
		TCF3	Unknown	26503763	GWAS catalog	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TCF4	Unknown	23453885 31835028 31926635 33479212	Disgenet, GWAS catalog	Myogenesis
		TCF7L2	Unknown	24322204	Disgenet, GWAS catalog	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TDO2	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +1 more
		TDRD15	Unknown	31043756 34002096	GWAS catalog	—
		TDRD9	Unknown	17554300 21254220	GWAS catalog	—
		TENM2	Unknown	31835028 31926635	GWAS catalog	—
		TENM4	Unknown	18711365 20351715 21926972 23453885 24618891 28115744 31043756 33263727 33686288 34002096	CTD, Disgenet, GWAS catalog	—
		TEX2	Unknown	34099189	GWAS catalog	—
		TFAP2B	Unknown	31043756 31835028 33479212 34159505	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
		TFAP2D	Unknown	24322204	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
		TFEC	Unknown	34099189	GWAS catalog	—
		TGFB1	Unknown	—	Disgenet	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +49 more
		TGM2	Unknown	—	Disgenet	Huntington disease
		TH	Unknown	—	Disgenet	Tyrosine metabolism Folate biosynthesis Metabolic pathways +7 more
		THBS3	Unknown	38858783	GWAS catalog	Phagosome PI3K-Akt signaling pathway Focal adhesion +5 more
		THOC7	Unknown	31835028	GWAS catalog	Nucleocytoplasmic transport Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing +1 more
		THRA	Unknown	34002096	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Thyroid hormone signaling pathway +2 more
		THSD4	Unknown	34099189	GWAS catalog	TGF-beta signaling pathway Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		THSD7A	Unknown	31043756 34002096 38154582	CTD, Disgenet, GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		TIMELESS	Unknown	—	Disgenet	Processing of DNA double-strand break ends
		TLCD4	Unknown	31043756 32606422 33479212 33686288 34159505	GWAS catalog	—
		TLCD4-RWDD3	Unknown	31043756 32606422	GWAS catalog	—
		TLE3	Unknown	19416921	GWAS catalog	Wnt signaling pathway Notch signaling pathway Formation of the beta-catenin:TCF transactivating complex +3 more
		TLE4	Unknown	21254220 34099189	GWAS catalog	Wnt signaling pathway Notch signaling pathway Formation of the beta-catenin:TCF transactivating complex +2 more
		TLL2	Unknown	—	Disgenet	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation +1 more
		TLR2	Unknown	—	Disgenet	Phagosome PI3K-Akt signaling pathway Neutrophil extracellular trap formation +30 more
		TLR4	Unknown	31926635	Disgenet, GWAS catalog	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
BIPOLAR I DISORDER	EFO_0009963	SYNE1	Unknown	31043756	GWAS catalog	Cytoskeleton in muscle cells
		TBC1D21	Unknown	34002096	GWAS catalog	—
		TDRD15	Unknown	31043756 34002096	GWAS catalog	—
		TENM4	Unknown	31043756	GWAS catalog	—
		TFAP2B	Unknown	31043756	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
		THSD7A	Unknown	34002096	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	SYNE1	Unknown	—	Disgenet	Cytoskeleton in muscle cells
		TAC1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events
		TACR1	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins +3 more
		TENM4	Unknown	—	Disgenet	—
		THSD7A	Unknown	—	Disgenet	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
MIXED BIPOLAR I DISORDER	C0236780	SYNE1	Unknown	—	Disgenet	Cytoskeleton in muscle cells
		TAC1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events
		TACR1	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins +3 more
		TENM4	Unknown	—	Disgenet	—
		THSD7A	Unknown	—	Disgenet	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

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