Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BIPOLAR DISORDER	MONDO_0004985 C0005586 MESH:D001714	AACS	Unknown	24322204	GWAS catalog	Valine, leucine and isoleucine degradation Butanoate metabolism Metabolic pathways +1 more
		ABCA13	Unknown	—	Disgenet	ABC transporters Neutrophil degranulation
		ABCD1	Unknown	20889312	GWAS catalog	ABC transporters Peroxisome ABC transporters in lipid homeostasis +5 more
		ACADS	Unknown	31835028 31926635	Disgenet, GWAS catalog	Fatty acid degradation Valine, leucine and isoleucine degradation beta-Alanine metabolism +7 more
		ACE	Unknown	—	Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACTB	Unknown	—	Disgenet	ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome +54 more
		ACTN3	Unknown	34002096 38154582	GWAS catalog	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Striated Muscle Contraction
		ACTR5	Unknown	31835028	GWAS catalog	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		ACTRT2	Unknown	34099189	GWAS catalog	—
		ADAM12	Unknown	34099189	GWAS catalog	Invadopodia formation
		ADAM19	Unknown	20889312 24322204	GWAS catalog	Invadopodia formation
		ADAMTS14	Unknown	21254220	GWAS catalog	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS19	Unknown	34099189	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS2	Unknown	34099189	GWAS catalog	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS6	Unknown	20889312	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADARB1	Unknown	—	Disgenet	C6 deamination of adenosine Formation of editosomes by ADAR proteins
		ADCY1	Unknown	29121268	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCY2	Unknown	24618891 27890468 31043756 33686288 34002096	CTD, Disgenet, GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +59 more
		ADCY3	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCY8	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCYAP1	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment +5 more
		ADD3	Unknown	28072414 31043756	CTD, Disgenet, GWAS catalog	Miscellaneous transport and binding events
		ADGRB1	Unknown	34099189	GWAS catalog	p53 signaling pathway Efferocytosis
		ADGRE3	Unknown	23453885	GWAS catalog	Class B/2 (Secretin family receptors) Neutrophil degranulation
		ADGRL4	Unknown	21926972 22182935 23453885 24280982 27890468 31043756	GWAS catalog	—
		ADM	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Vascular smooth muscle contraction G alpha (s) signalling events +2 more
		ADO	Unknown	34002096	GWAS catalog	Taurine and hypotaurine metabolism Metabolic pathways Degradation of cysteine and homocysteine
		ADRA1A	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +8 more
		ADRA1D	Unknown	23453885	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +7 more
		ADRA2C	Unknown	—	Disgenet	cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		ADRB2	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +13 more
		AFG1L	Unknown	—	Disgenet	—
		AGL	Unknown	23218918	GWAS catalog	Starch and sucrose metabolism Metabolic pathways Neutrophil degranulation +1 more
		AGT	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		AIFM1	Unknown	31043756	GWAS catalog	Apoptosis Necroptosis
		AIM2	Unknown	26433762	GWAS catalog	NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway The AIM2 inflammasome
		AK5	Unknown	31043756 38250258	GWAS catalog	Purine metabolism Thiamine metabolism Metabolic pathways +3 more
		AKAP10	Unknown	—	Disgenet	Factors involved in megakaryocyte development and platelet production
		AKAP11	Unknown	35410376	CTD, Disgenet	—
		AKAP6	Unknown	31043756 31835028	GWAS catalog	—
		AKR1C4	Unknown	21570127	CTD, Disgenet	Primary bile acid biosynthesis Steroid hormone biosynthesis Metabolic pathways +5 more
		AKT1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		ALAS1	Unknown	38154582	GWAS catalog	Glycine, serine and threonine metabolism Porphyrin metabolism Metabolic pathways +4 more
		ALDH2	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALG14	Unknown	33479212 33686288 34159505	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +2 more
		ALMS1	Unknown	38858783	GWAS catalog	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		ALOX12	Unknown	—	Disgenet	Arachidonic acid metabolism Metabolic pathways Antifolate resistance +8 more
		ALOX5AP	Unknown	34002096 38154582	GWAS catalog	Fc epsilon RI signaling pathway Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) +1 more
		AMBRA1	Unknown	31835028	GWAS catalog	Mitophagy - animal Autophagy - animal Alzheimer disease +5 more
BIPOLAR I DISORDER	EFO_0009963	ADCY2	Unknown	34002096	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +59 more
		AK5	Unknown	31043756	GWAS catalog	Purine metabolism Thiamine metabolism Metabolic pathways +3 more
		ALOX5AP	Unknown	34002096	GWAS catalog	Fc epsilon RI signaling pathway Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) +1 more
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	C0024713	ADCY2	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +59 more
		ADD3	Unknown	—	Disgenet	Miscellaneous transport and binding events
		AKAP11	Unknown	—	Disgenet	—
		AKT1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
MIXED BIPOLAR I DISORDER	C0236780	ADCY2	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +59 more
		ADD3	Unknown	—	Disgenet	Miscellaneous transport and binding events
		AKAP11	Unknown	—	Disgenet	—
		AKT1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more

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Bipolar disorder

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