Attention deficit hyperactivity disorder

Hedgehog signaling pathway Hedgehog 'off' state Hedgehog 'on' state

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism +7 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Dopaminergic synapse Huntington disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Nicotine addiction Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules +12 more

Neuroactive ligand-receptor interaction Long-term depression

Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor +1 more

Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Ca-permeable Kainate Receptor Presynaptic function of Kainate receptors +1 more

Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Ca-permeable Kainate Receptor

Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Dopaminergic synapse Alzheimer disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Systemic lupus erythematosus Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors +19 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +3 more

Cytosolic DNA-sensing pathway

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation +33 more

Antigen processing: Ubiquitination & Proteasome degradation

Hyaluronan biosynthesis and export

Endocrine resistance ErbB signaling pathway GnRH signaling pathway Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action Epithelial cell signaling in Helicobacter pylori infection Coronavirus disease - COVID-19 Proteoglycans in cancer Bladder cancer Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +36 more

GnRH secretion HCN channels

Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis MicroRNAs in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX3 regulates p14-ARF +8 more

Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis +21 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis MHC class II antigen presentation +22 more

Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)

AMPK signaling pathway Maturity onset diabetes of the young Nuclear Receptor transcription pathway

Spliceosome Viral carcinogenesis MicroRNAs in cancer SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events +4 more

Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS-GAG biosynthesis

Fatty acid elongation Steroid hormone biosynthesis Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs +4 more

Regulation of HSF1-mediated heat shock response

cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction Serotonin receptors G alpha (i) signalling events +3 more

Huntington disease Pathways of neurodegeneration - multiple diseases

Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity Hepatitis C Measles Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Interferon alpha/beta signaling Regulation of IFNA signaling +16 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway HIF-1 signaling pathway FoxO signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal Endocytosis mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Long-term depression Ovarian steroidogenesis Progesterone-mediated oocyte maturation Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer Glioma Prostate cancer Melanoma Breast cancer Hepatocellular carcinoma Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling +31 more

Cell adhesion molecules