Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS	MESH:D019958	DRD4	Unknown	20731709	CTD	Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse +2 more
ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS	MESH:D019958	S100B	Unknown	25451971	CTD	Nuclear signaling by ERBB4 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling +1 more
ATTENTION DEFICIT DISORDER	C0041671	ACP1	Unknown	—	Disgenet	Thiamine metabolism Riboflavin metabolism Metabolic pathways +2 more
ATTENTION DEFICIT DISORDER	C0041671	ADGRL3	Unknown	—	Disgenet	—
ATTENTION DEFICIT DISORDER	C0041671	ADRA2A	Unknown	—	Disgenet	cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
ATTENTION DEFICIT DISORDER	C0041671	AR	Unknown	—	Disgenet	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
ATTENTION DEFICIT DISORDER	C0041671	AS3MT	Unknown	—	Disgenet	Chemical carcinogenesis - reactive oxygen species Methylation
ATTENTION DEFICIT DISORDER	C0041671	BAIAP2	Unknown	—	Disgenet	Adherens junction Regulation of actin cytoskeleton Pathogenic Escherichia coli infection +5 more
ATTENTION DEFICIT DISORDER	C0041671	CALY	Unknown	—	Disgenet	Dopaminergic synapse
ATTENTION DEFICIT DISORDER	C0041671	CHRNA4	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
ATTENTION DEFICIT DISORDER	C0041671	CHRNB2	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
ATTENTION DEFICIT DISORDER	C0041671	CNR1	Unknown	—	Disgenet	Rap1 signaling pathway Neuroactive ligand-receptor interaction Thermogenesis +3 more
ATTENTION DEFICIT DISORDER	C0041671	COMT	Unknown	—	Disgenet	Steroid hormone biosynthesis Tyrosine metabolism Metabolic pathways +4 more
ATTENTION DEFICIT DISORDER	C0041671	DBH	Unknown	—	Disgenet	Tyrosine metabolism Metabolic pathways Catecholamine biosynthesis
ATTENTION DEFICIT DISORDER	C0041671	DCDC2	Unknown	—	Disgenet	—
ATTENTION DEFICIT DISORDER	C0041671	DOCK3	Unknown	—	Disgenet	NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
ATTENTION DEFICIT DISORDER	C0041671	DRD2	Unknown	—	Disgenet	Rap1 signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +7 more
ATTENTION DEFICIT DISORDER	C0041671	DRD4	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse +2 more
ATTENTION DEFICIT DISORDER	C0041671	DRD5	Unknown	—	Disgenet	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +5 more
ATTENTION DEFICIT DISORDER	C0041671	FGD1	Unknown	—	Disgenet	Regulation of actin cytoskeleton NRAGE signals death through JNK Rho GTPase cycle +1 more
ATTENTION DEFICIT DISORDER	C0041671	FOXP2	Unknown	—	Disgenet	—
ATTENTION DEFICIT DISORDER	C0041671	GIT1	Unknown	—	Disgenet	Endocytosis Regulation of actin cytoskeleton Epithelial cell signaling in Helicobacter pylori infection +1 more
ATTENTION DEFICIT DISORDER	C0041671	GRM1	Unknown	—	Disgenet	Calcium signaling pathway FoxO signaling pathway Phospholipase D signaling pathway +13 more
ATTENTION DEFICIT DISORDER	C0041671	GRM5	Unknown	—	Disgenet	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
ATTENTION DEFICIT DISORDER	C0041671	GRM7	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
ATTENTION DEFICIT DISORDER	C0041671	GRM8	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
ATTENTION DEFICIT DISORDER	C0041671	HMGCR	Unknown	—	Disgenet	Terpenoid backbone biosynthesis Metabolic pathways AMPK signaling pathway +5 more
ATTENTION DEFICIT DISORDER	C0041671	HTR1B	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
ATTENTION DEFICIT DISORDER	C0041671	MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
ATTENTION DEFICIT DISORDER	C0041671	PTPRD	Unknown	—	Disgenet	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
ATTENTION DEFICIT DISORDER	C0041671	SLC6A3	Unknown	—	Disgenet	Synaptic vesicle cycle Dopaminergic synapse Parkinson disease +7 more
ATTENTION DEFICIT DISORDER	C0041671	SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
ATTENTION DEFICIT DISORDER	C0041671	STS	Unknown	—	Disgenet	Steroid hormone biosynthesis Metabolic pathways Glycosphingolipid metabolism +1 more
ATTENTION DEFICIT DISORDER	C0041671	TACR1	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins +3 more
ATTENTION DEFICIT DISORDER	C0041671	TPH1	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +3 more
ATTENTION DEFICIT DISORDER	C0041671	TPH2	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +2 more
ATTENTION DEFICIT DISORDER	C0041671	UST	Unknown	—	Disgenet	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Dermatan sulfate biosynthesis
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	ADGRL3	Unknown	22405201	CTD	—
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	AS3MT	Unknown	25461954	CTD	Chemical carcinogenesis - reactive oxygen species Methylation
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	CALY	Unknown	30753204	CTD	Dopaminergic synapse
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	CHRNA4	Unknown	21748252	CTD	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	CHRNB2	Unknown	21748252	CTD	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	CIC	Unknown	28288114	CTD	Spinocerebellar ataxia
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	CNR1	Unknown	22034972	CTD	Rap1 signaling pathway Neuroactive ligand-receptor interaction Thermogenesis +3 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	COMT	Unknown	10490706	CTD	Steroid hormone biosynthesis Tyrosine metabolism Metabolic pathways +4 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	DRD2	Unknown	17671965	CTD	Rap1 signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +7 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	DRD4	Unknown	14699430 14699433 17671965 29054088	CTD	Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse +2 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	DRD5	Unknown	14699430 14732906	CTD	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +5 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	FGD1	Unknown	15809997	CTD	Regulation of actin cytoskeleton NRAGE signals death through JNK Rho GTPase cycle +1 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	GIT1	Unknown	21499268	CTD	Endocytosis Regulation of actin cytoskeleton Epithelial cell signaling in Helicobacter pylori infection +1 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	GRM1	Unknown	22138692	CTD	Calcium signaling pathway FoxO signaling pathway Phospholipase D signaling pathway +13 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	GRM5	Unknown	19546859 22138692	CTD	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	GRM7	Unknown	22138692	CTD	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	GRM8	Unknown	22138692	CTD	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	PTPRD	Unknown	19546859	CTD	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	SLC6A3	Unknown	12699766 15059031 19120712 22034972	CTD	Synaptic vesicle cycle Dopaminergic synapse Parkinson disease +7 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	STS	Unknown	18413370	CTD	Steroid hormone biosynthesis Metabolic pathways Glycosphingolipid metabolism +1 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	TACR1	Unknown	19204064	CTD	Calcium signaling pathway Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins +3 more
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	MESH:D001289	TPH2	Unknown	—	CTD	Tryptophan metabolism Folate biosynthesis Metabolic pathways +2 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	ADGRL1	Causal	—	Disgenet	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	CHAF1B	Causal	—	Disgenet	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	FERRY3	Causal	—	Disgenet	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	GNB5	Causal	—	Disgenet	Ras signaling pathway Chemokine signaling pathway Hormone signaling +43 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	KIF5B	Causal	—	Disgenet	Endocytosis Dopaminergic synapse Motor proteins +12 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	MECP2	Causal	—	Disgenet	Transcriptional Regulation by MECP2 Loss of MECP2 binding ability to 5hmC-DNA Loss of MECP2 binding ability to 5mC-DNA +2 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	SCAPER	Causal	—	Disgenet	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	TBR1	Causal	—	Disgenet	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	TCF20	Causal	31835028 34446935	Disgenet, GWAS catalog	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	A3GALT2	Unknown	38565336	GWAS catalog	Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	AATK	Unknown	34446935	GWAS catalog	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	ABCA12	Unknown	40962958	GWAS catalog	ABC transporters ABC transporters in lipid homeostasis Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	ABCB9	Unknown	35764056	GWAS catalog	ABC transporters Lysosome ABC-family proteins mediated transport
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	ADGRL3	Unknown	34446935	GWAS catalog	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	AS3MT	Unknown	23453885 33686288	GWAS catalog	Chemical carcinogenesis - reactive oxygen species Methylation
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	BAIAP2	Unknown	34446935	Disgenet, GWAS catalog	Adherens junction Regulation of actin cytoskeleton Pathogenic Escherichia coli infection +5 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	DRD2	Unknown	31835028 33479212 36137488	GWAS catalog	Rap1 signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +7 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	DRD4	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse +2 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	DRD5	Unknown	—	Disgenet	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction +5 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	FOXP2	Unknown	30610198 32606422 34446935 35927488 36137488 36702997 36753304 37689771 38036780 38565336 40962958	GWAS catalog	—
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	GRM5	Unknown	22012869 33479212 36738649	GWAS catalog	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	GRM8	Unknown	34446935	GWAS catalog	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +2 more
ATTENTION DEFICIT HYPERACTIVITY DISORDER	C1263846 EFO_0003888	PTPRD	Unknown	18951430	GWAS catalog	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7	MONDO:0013076	TPH2	Unknown	18347598	ClinVar, GWAS catalog	Tryptophan metabolism Folate biosynthesis Metabolic pathways +2 more

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Attention deficit hyperactivity disorder

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