Ankylosing spondylitis

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS-GAG biosynthesis

Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum Endocytosis Longevity regulating pathway - multiple species Antigen processing and presentation Estrogen signaling pathway Prion disease Legionellosis Toxoplasmosis Measles Lipid and atherosclerosis Regulation of HSF1-mediated heat shock response Neutrophil degranulation +11 more

RIG-I-like receptor signaling pathway Hepatitis B Measles Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling +11 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis Osteoclast differentiation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Influenza A Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Interferon gamma signaling Regulation of IFNG signaling +16 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Other interleukin signaling Interleukin-20 family signaling +1 more

MAPK signaling pathway Ras signaling pathway Hormone signaling PI3K-Akt signaling pathway Pathways in cancer Proteoglycans in cancer Hepatocellular carcinoma Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +9 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway Efferocytosis C-type lectin receptor signaling pathway JAK-STAT signaling pathway T cell receptor signaling pathway Intestinal immune network for IgA production Pertussis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Staphylococcus aureus infection Tuberculosis Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Allograft rejection Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis +25 more

Cytokine-cytokine receptor interaction Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Alcoholic liver disease Type I diabetes mellitus Pertussis Legionellosis Leishmaniasis Chagas disease African trypanosomiasis Toxoplasmosis Amoebiasis Tuberculosis Measles Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer Inflammatory bowel disease Allograft rejection Lipid and atherosclerosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-23 signaling +26 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th1 and Th2 cell differentiation Pathways in cancer Inflammatory bowel disease Interleukin-35 Signalling Interleukin-12 signaling +4 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Intestinal immune network for IgA production Human T-cell leukemia virus 1 infection Pathways in cancer Interleukin-15 signaling +3 more

Cytokine-cytokine receptor interaction IL-17 signaling pathway Th17 cell differentiation Alcoholic liver disease Inflammatory bowel disease Rheumatoid arthritis Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling +5 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor TNF signaling pathway Inflammatory bowel disease Interleukin-37 signaling Interleukin-18 signaling +3 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Inflammatory bowel disease Interleukin-18 signaling +1 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway Interleukin-20 family signaling +1 more

MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Osteoclast differentiation Hematopoietic cell lineage Th17 cell differentiation Inflammatory mediator regulation of TRP channels Pathogenic Escherichia coli infection Shigellosis Amoebiasis Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Fluid shear stress and atherosclerosis Interleukin-10 signaling Interleukin-1 signaling +12 more

Cytokine-cytokine receptor interaction Hematopoietic cell lineage Amoebiasis Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer Prostate cancer Fluid shear stress and atherosclerosis Interleukin-10 signaling Interleukin-1 signaling +6 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Intestinal immune network for IgA production Type I diabetes mellitus Yersinia infection Chagas disease Measles Human T-cell leukemia virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Autoimmune thyroid disease Inflammatory bowel disease Allograft rejection Graft-versus-host disease RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling +21 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation Inflammatory bowel disease Interleukin-21 signaling +2 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation Pathways in cancer Inflammatory bowel disease Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling +4 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation Interleukin-27 signaling +1 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Measles Human T-cell leukemia virus 1 infection Pathways in cancer RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling +12 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

EGFR tyrosine kinase inhibitor resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Th17 cell differentiation Non-alcoholic fatty liver disease Human cytomegalovirus infection Coronavirus disease - COVID-19 Pathways in cancer Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling +13 more

Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Primary immunodeficiency Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +7 more

MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway Neurotrophin signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling IRAK1 recruits IKK complex TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane +33 more

C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway Pertussis Human papillomavirus infection Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production +5 more

Toll-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling

NOD-like receptor signaling pathway Toxoplasmosis

Rap1 signaling pathway Cell adhesion molecules Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration Regulation of actin cytoskeleton Malaria Staphylococcus aureus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Rheumatoid arthritis Viral myocarditis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration +14 more

Antimicrobial peptides

EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Cholinergic synapse Prolactin signaling pathway Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis B Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Prolactin receptor signaling Signaling by SCF-KIT RMTs methylate histone arginines Interleukin-3, Interleukin-5 and GM-CSF signaling RAF activation RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cyclin D associated events in G1 Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-27 signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS Interleukin receptor SHC signaling Signaling downstream of RAS mutants Growth hormone receptor signaling Factors involved in megakaryocyte development and platelet production +51 more

Voltage gated Potassium channels

HDMs demethylate histones

Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation +6 more

Motor proteins Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins +7 more

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Motor proteins MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins +2 more

Nucleocytoplasmic transport Influenza A Chemical carcinogenesis - receptor activation ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways +2 more

Nucleocytoplasmic transport Chemical carcinogenesis - receptor activation ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Inhibition of nitric oxide production +8 more

N-Glycan biosynthesis Various types of N-glycan biosynthesis Protein processing in endoplasmic reticulum

Ras signaling pathway C-type lectin receptor signaling pathway Tuberculosis RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +8 more

Formation of the cornified envelope

Formation of the cornified envelope

Lysosome

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Cytokine-cytokine receptor interaction IL-17 signaling pathway Th17 cell differentiation Alcoholic liver disease Inflammatory bowel disease Rheumatoid arthritis Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling +5 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more