Ankylosing spondylitis

Cytokine-cytokine receptor interaction Apoptosis JAK-STAT signaling pathway Pathways in cancer Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Interleukin receptor SHC signaling +7 more

Cell adhesion molecules T cell receptor signaling pathway Autoimmune thyroid disease Rheumatoid arthritis CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) +3 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Phospholipase D signaling pathway Endocytosis Epithelial cell signaling in Helicobacter pylori infection Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation +6 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Phospholipase D signaling pathway Endocytosis Epithelial cell signaling in Helicobacter pylori infection Human cytomegalovirus infection Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation +7 more

Steroid hormone biosynthesis Tryptophan metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Ovarian steroidogenesis Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins +12 more

Virion - Lassa virus and SFTS virus ECM-receptor interaction Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation Regulation of expression of SLITs and ROBOs +10 more

Pyrimidine metabolism Metabolic pathways Nucleotide metabolism Interconversion of nucleotide di- and triphosphates +1 more

RAB GEFs exchange GTP for GDP on RABs

Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Glycine, serine and threonine metabolism Valine, leucine and isoleucine degradation Lysine degradation Tryptophan metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism One carbon pool by folate Lipoic acid metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of cofactors Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle) +20 more

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Cysteine and methionine metabolism Metabolic pathways MicroRNAs in cancer PRC2 methylates histones and DNA SUMOylation of DNA methylation proteins +2 more

Rap1 signaling pathway Factors involved in megakaryocyte development and platelet production

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Lipid and atherosclerosis IRE1alpha activates chaperones +9 more

Ras signaling pathway Cellular senescence Human T-cell leukemia virus 1 infection Pathways in cancer Renal cell carcinoma Oncogene Induced Senescence +3 more

Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction p53 signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Chagas disease African trypanosomiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Lipid and atherosclerosis Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling +36 more

Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Phagosome Osteoclast differentiation Platelet activation Neutrophil extracellular trap formation Fc gamma R-mediated phagocytosis Pathogenic Escherichia coli infection Yersinia infection Leishmaniasis Staphylococcus aureus infection Tuberculosis Coronavirus disease - COVID-19 Systemic lupus erythematosus FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis +14 more

Shigellosis Clathrin-mediated endocytosis

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways ABO blood group biosynthesis Lewis blood group biosynthesis +2 more

Starch and sucrose metabolism Metabolic pathways Glycosphingolipid metabolism

Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Conjugation of salicylate with glycine Conjugation of benzoate with glycine

MAPK signaling pathway cGMP-PKG signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Vascular smooth muscle contraction Long-term depression Regulation of actin cytoskeleton Parathyroid hormone synthesis, secretion and action Pathogenic Escherichia coli infection Human cytomegalovirus infection Pathways in cancer G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) +11 more

Neuroactive ligand-receptor interaction Class A/1 (Rhodopsin-like receptors)

Cocaine addiction G alpha (i) signalling events

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway +4 more

Hedgehog signaling pathway Hedgehog ligand biogenesis HHAT G278V abrogates palmitoylation of Hh-Np

Maturity onset diabetes of the young Transcriptional misregulation in cancer

Regulation of gene expression by Hypoxia-inducible Factor Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation +1 more

Cellular senescence YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Regulation of TP53 Activity through Phosphorylation +1 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction p53 signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Chagas disease African trypanosomiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Lipid and atherosclerosis Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling +36 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more