Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute myeloid leukemia	MONDO_0018874 MONDO_0044923	ATRX	Unknown	26941285 26438511 27276561 35805006 27881874 34778799	Open Targets	Cell cycle
		AXIN1	Unknown	24056718	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	30013198	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BARD1	Unknown	24036946	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BAX	Unknown	30013198	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more
		BCL10	Unknown	29253671	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	30013198	Open Targets	—
		BCL11B	Unknown	25962120 21399634 34778799	Open Targets	Transcriptional misregulation in cancer
		BCL6	Unknown	37002311	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL9	Unknown	34778799	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCL9L	Unknown	31648334	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	22237025 34778799	Open Targets	—
		BCORL1	Unknown	21989985 25596268 25652455 25962120 26438511 26728869 26980726 27288520 27435003 27470916 27798625 27881874 28063196 29663558 30013198 34070172 35805006 37002311 37102976 37853686 38212634	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	34778799	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRAF	Unknown	37002311 26728869 29795382 37102976 27470916 27276561 27288520 24571676 14603338 34778799	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	22237025	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	31475115 37002311 26886259 30013198 38212634 34778799	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BTG1	Unknown	22237025	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BUB1B	Unknown	25962120	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CACNA1D	Unknown	34778799	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CAMTA1	Unknown	22237025 24056718 34778799	Open Targets	—
		CASP8	Unknown	29191655	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CBFA2T3	Unknown	27094503 24127550 23153540 23407549 24056718 27114462 23045605	Open Targets	—
		CBFB	Unknown	34778799	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBLB	Unknown	37002311 27276561 17475912	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CBLC	Unknown	22976956 27063598	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CCDC6	Unknown	34778799	Open Targets	Pathways in cancer Thyroid cancer
		CCND2	Unknown	27798625 29253671 26941285 38019014 22976956 31648334 34778799	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	34301788 38212634 35986270 21399634	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CD74	Unknown	22237025	Open Targets	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection +2 more
		CDC73	Unknown	25962120	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH10	Unknown	22237025	Open Targets	Adherens junctions interactions
		CDH11	Unknown	22237025	Open Targets	Adherens junctions interactions
		CDK12	Unknown	29795382 34778799	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDK6	Unknown	34778799	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +27 more
		CDKN1B	Unknown	34778799	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	37002311 7544647 9447829 7882348 7632963 23856246 22976956 8616035 7795238 37853686 27276561 27288520 7577621 7882134 22072402 34778799	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHD2	Unknown	24036946	Open Targets	—
		CHD4	Unknown	29253671 34778799	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CLTC	Unknown	34778799	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CNBD1	Unknown	31648334	Open Targets	—
		CNTNAP2	Unknown	22237025	Open Targets	Cell adhesion molecules
		CNTRL	Unknown	27798625 22237025	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		COL3A1	Unknown	27798625	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CREBBP	Unknown	24523240 37002311 10706136 27798625 27470916 21390130 27276561 34301788 38212634	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRTC1	Unknown	34778799	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	2406720 2142747	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	11071667 11238134 12203110 12763135 18528462 19016735 19794089 19833857 22146088 22371884 23508011 23656643 24523240 25412851 25858548 26728869 27030388 27288520 27798625 29253671 30013198 34778799 34818692 35805006 37002311 37102976 38212634 7542747 8652369 9001427 9116280	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	29253671 22237025 26883104 24056718 37305720	Open Targets	—
		CTCF	Unknown	37002311 29253671 22976956 23153540 22237025 24056718 38212634 21399634 34778799	Open Targets	—

Acute myeloid leukemia

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