← Back to all clusters

Cluster 15

27 diseases · 53 shared-gene connections
27 Diseases
90 Unique genes
0.040 Avg. similarity score
Ciliary dyskinesia Most-connected disease (26 links)
Log in to save this analysis

Save This Analysis

Disease Searched: Primary ciliary dyskinesia 10 Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
CCNO 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 29
CFAP298 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 26
DNAAF11 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 19
DNAAF5 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 18
DRC2 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 27
DRC4 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 33
ODAD1 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 20
ODAD2 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 23
ZMYND10 4 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia, Primary ciliary dyskinesia 22
CCDC39 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
CCDC40 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
CFAP221 3 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia, Young syndrome
DNAAF19 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
DNAAF2 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia 10
DNAAF3 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
DNAH5 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
DNAI2 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia 9
DNAL1 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia 16
DRC1 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
HYDIN 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia
RSPH1 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia 24
RSPH3 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia 32
RSPH9 3 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia, Primary ciliary dyskinesia 12
TTC12 3 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 45, Primary ciliary dyskinesia
CFAP300 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
CFAP43 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
CFAP57 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
CFAP74 2 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 49, without situs inversus
CLXN 2 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 53
DAW1 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
DNAAF1 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
DNAAF4 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
DNAAF6 2 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 36, x-linked
DNAH1 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
DNAH10 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
DNAH11 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
DNAH7 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
DNAI1 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
DNAJB13 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia 34
GAS2L2 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
NME5 2 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 48, without situs inversus
NME8 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
ODAD3 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
OFD1 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
RSPH4A 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
SPAG1 2 / 27 Ciliary dyskinesia, Congenital nasopharyngeal atresia
SPEF2 2 / 27 Ciliary dyskinesia, Primary ciliary dyskinesia
STK36 2 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 46
TP73 2 / 27 Ciliary dyskinesia, Ciliary dyskinesia, primary, 47, and lissencephaly
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Motor proteins KEGG 14 / 194 9.6× 1.59e-10 1.76e-8 ✓ sig.
Huntington disease KEGG 14 / 308 6.1× 6.20e-8 3.69e-6 ✓ sig.
Pathways of neurodegeneration - multiple diseases KEGG 15 / 480 4.2× 2.47e-6 9.03e-5 ✓ sig.
Amyotrophic lateral sclerosis KEGG 13 / 368 4.7× 3.30e-6 1.16e-4 ✓ sig.
Hedgehog 'off' state Reactome 5 / 56 11.9× 5.97e-5 1.26e-3 ✓ sig.
Intraflagellar transport Reactome 3 / 54 7.4× 7.66e-3 4.81e-2 ✓ sig.
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome 2 / 20 13.3× 9.67e-3 5.57e-2
CD209 (DC-SIGN) signaling Reactome 2 / 21 12.7× 1.06e-2 5.91e-2
Glycogen storage disease type II (GAA) Reactome 1 / 2 66.7× 1.49e-2 7.23e-2
ARL13B-mediated ciliary trafficking of INPP5E Reactome 1 / 3 44.5× 2.23e-2 9.12e-2
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome 1 / 5 26.7× 3.69e-2 1.22e-1
Anchoring of the basal body to the plasma membrane Reactome 3 / 98 4.1× 3.72e-2 1.22e-1
CLEC7A/inflammasome pathway Reactome 1 / 6 22.2× 4.41e-2 1.35e-1
HIF-1 signaling pathway KEGG 3 / 110 3.6× 4.95e-2 1.44e-1
IkBA variant leads to EDA-ID Reactome 1 / 7 19.1× 5.13e-2 1.47e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
cilium movement GO:0003341 24 / 48 104× 2.50e-44 3.81e-40 ✓ sig.
outer dynein arm assembly GO:0036158 17 / 22 160× 2.09e-36 1.85e-32 ✓ sig.
cell projection organization GO:0030030 25 / 214 24.3× 4.30e-28 2.05e-24 ✓ sig.
epithelial cilium movement involved in extracellular fluid movement GO:0003351 14 / 26 112× 1.15e-26 4.52e-23 ✓ sig.
cilium movement involved in cell motility GO:0060294 14 / 27 108× 2.39e-26 9.00e-23 ✓ sig.
axonemal dynein complex assembly GO:0070286 11 / 16 143× 7.35e-23 1.73e-19 ✓ sig.
inner dynein arm assembly GO:0036159 11 / 18 127× 5.32e-22 1.14e-18 ✓ sig.
cilium assembly GO:0060271 21 / 237 18.4× 4.71e-21 8.87e-18 ✓ sig.
determination of left/right symmetry GO:0007368 15 / 83 37.5× 4.79e-20 7.66e-17 ✓ sig.
cerebrospinal fluid circulation GO:0090660 10 / 18 115× 1.70e-19 2.52e-16 ✓ sig.
motile cilium assembly GO:0044458 11 / 28 81.6× 3.45e-19 4.88e-16 ✓ sig.
axoneme assembly GO:0035082 11 / 33 69.2× 3.05e-18 3.74e-15 ✓ sig.
flagellated sperm motility GO:0030317 15 / 142 21.9× 2.15e-16 1.96e-13 ✓ sig.
epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 8 / 13 128× 2.66e-16 2.38e-13 ✓ sig.
mucociliary clearance GO:0120197 7 / 12 121× 3.68e-14 2.30e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Ciliary dyskinesia Congenital nasopharyngeal atresia 0.337 30 1.62e-70 5.33e-69 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 0.308 28 4.72e-63 1.46e-61 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 0.356 16 4.02e-38 9.15e-37 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 26 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 20 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 20 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Young syndrome 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 22 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 23 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 23 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 24 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 26 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 9 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 27 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 22 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 27 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 29 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 29 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 32 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 33 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 33 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 19 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 10 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 12 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 16 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Ciliary dyskinesia, primary, 45 Primary ciliary dyskinesia 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 18 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Primary ciliary dyskinesia Primary ciliary dyskinesia 18 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Congenital nasopharyngeal atresia Primary ciliary dyskinesia 19 0.032 1 1.94e-3 2.65e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 9 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 34 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 36, x-linked 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 33 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 45 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 46 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 32 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 47, and lissencephaly 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Young syndrome 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 29 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 48, without situs inversus 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 49, without situs inversus 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 27 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, primary, 53 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 26 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 10 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 24 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 12 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 23 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 16 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 22 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 20 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 18 0.011 1 5.68e-3 6.72e-3 ✓ sig.
Ciliary dyskinesia Primary ciliary dyskinesia 19 0.011 1 5.68e-3 6.72e-3 ✓ sig.