Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
← Back to all clusters
Cluster 256
8
Diseases
31
Unique genes
0.228
Avg. similarity score
Exudative retinopathy
Most-connected disease (7 links)
Disease
Searched: Norrie disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) ·
drag a node to pin it in place · scroll/pinch to zoom.
Norrie disease
Exudative retinopathy
Exudative vitreoretinopathy
Coats disease
Atrophia bulborum heritaria
Exudative vitreoretinopathy 2, x-linked
Retinal dystrophy with or without extraocular anomalies
Retinopathy of prematurity
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Exudative retinopathy | 7 | 7 | 7 |
| Exudative vitreoretinopathy | 7 | 7 | 12 |
| Coats disease | 6 | 6 | 2 |
| Atrophia bulborum heritaria | 5 | 5 | 1 |
| Exudative vitreoretinopathy 2, x-linked | 5 | 5 | 1 |
| Norrie disease | 5 | 5 | 1 |
| Retinal dystrophy with or without extraocular anomalies | 3 | 3 | 1 |
| Retinopathy of prematurity | 2 | 2 | 20 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| NDP | 7 / 8 | Atrophia bulborum heritaria, Coats disease, Exudative retinopathy, Exudative vitreoretinopathy and 3 more |
| RCBTB1 | 4 / 8 | Coats disease, Exudative retinopathy, Exudative vitreoretinopathy, Retinal dystrophy with or without extraocular anomalies |
| FZD4 | 3 / 8 | Exudative retinopathy, Exudative vitreoretinopathy, Retinopathy of prematurity |
| PRSS23 | 3 / 8 | Exudative retinopathy, Exudative vitreoretinopathy, Retinopathy of prematurity |
| LRP5 | 2 / 8 | Exudative vitreoretinopathy, Retinopathy of prematurity |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| VEGFR2 mediated vascular permeability | Reactome | 4 / 29 | 53.4× | 8.25e-7 | 3.52e-5 ✓ sig. |
| RNF mutants show enhanced WNT signaling and proliferation | Reactome | 3 / 8 | 145× | 8.64e-7 | 3.67e-5 ✓ sig. |
| Leukocyte transendothelial migration | KEGG | 5 / 116 | 16.7× | 1.07e-5 | 3.08e-4 ✓ sig. |
| Regulation of FZD by ubiquitination | Reactome | 3 / 21 | 55.3× | 2.01e-5 | 5.23e-4 ✓ sig. |
| Breast cancer | KEGG | 5 / 148 | 13.1× | 3.48e-5 | 8.20e-4 ✓ sig. |
| Gastric cancer | KEGG | 5 / 150 | 12.9× | 3.72e-5 | 8.63e-4 ✓ sig. |
| Pathways in cancer | KEGG | 8 / 533 | 5.8× | 4.55e-5 | 1.01e-3 ✓ sig. |
| Cell adhesion molecules | KEGG | 5 / 160 | 12.1× | 5.06e-5 | 1.10e-3 ✓ sig. |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | Reactome | 3 / 30 | 38.7× | 6.03e-5 | 1.27e-3 ✓ sig. |
| Adherens junctions interactions | Reactome | 3 / 32 | 36.3× | 7.34e-5 | 1.48e-3 ✓ sig. |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | Reactome | 2 / 8 | 96.9× | 1.79e-4 | 3.01e-3 ✓ sig. |
| InlA-mediated entry of Listeria monocytogenes into host cells | Reactome | 2 / 9 | 86.1× | 2.30e-4 | 3.66e-3 ✓ sig. |
| Basal cell carcinoma | KEGG | 3 / 63 | 18.4× | 5.57e-4 | 7.27e-3 ✓ sig. |
| Hippo signaling pathway | KEGG | 4 / 157 | 9.9× | 6.72e-4 | 8.36e-3 ✓ sig. |
| Hepatocellular carcinoma | KEGG | 4 / 170 | 9.1× | 9.05e-4 | 1.05e-2 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Norrin signaling pathway | GO:0110135 | 4 / 4 | 603× | 6.19e-12 | 2.47e-9 ✓ sig. |
| establishment of blood-brain barrier | GO:0060856 | 4 / 11 | 219× | 2.03e-9 | 4.29e-7 ✓ sig. |
| extracellular matrix-cell signaling | GO:0035426 | 3 / 4 | 452× | 1.65e-8 | 2.72e-6 ✓ sig. |
| retinal blood vessel morphogenesis | GO:0061304 | 3 / 6 | 301× | 8.24e-8 | 1.08e-5 ✓ sig. |
| establishment of blood-retinal barrier | GO:1990963 | 3 / 6 | 301× | 8.24e-8 | 1.08e-5 ✓ sig. |
| Wnt signaling pathway | GO:0016055 | 7 / 232 | 18.2× | 8.47e-8 | 1.10e-5 ✓ sig. |
| retina vasculature morphogenesis in camera-type eye | GO:0061299 | 3 / 7 | 258× | 1.44e-7 | 1.73e-5 ✓ sig. |
| blood vessel remodeling | GO:0001974 | 4 / 42 | 57.4× | 6.64e-7 | 6.15e-5 ✓ sig. |
| canonical Wnt signaling pathway | GO:0060070 | 5 / 105 | 28.7× | 7.70e-7 | 6.92e-5 ✓ sig. |
| retina vasculature development in camera-type eye | GO:0061298 | 3 / 15 | 121× | 1.86e-6 | 1.43e-4 ✓ sig. |
| embryonic digit morphogenesis | GO:0042733 | 4 / 57 | 42.3× | 2.30e-6 | 1.70e-4 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 9 / 778 | 7.0× | 3.17e-6 | 2.19e-4 ✓ sig. |
| endothelial cell differentiation | GO:0045446 | 3 / 18 | 100× | 3.32e-6 | 2.27e-4 ✓ sig. |
| gene expression | GO:0010467 | 6 / 269 | 13.4× | 4.58e-6 | 2.96e-4 ✓ sig. |
| angiogenesis | GO:0001525 | 6 / 284 | 12.7× | 6.25e-6 | 3.78e-4 ✓ sig. |