Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 419

5 diseases · 9 shared-gene connections
5 Diseases
18 Unique genes
0.244 Avg. similarity score
Connective and soft tissue disorder Most-connected disease (4 links)
Log in to save this analysis

Save This Analysis

Disease Searched: Connective and soft tissue disorder Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Connective and soft tissue disorder 4 4 1
Vascular ehlers-danlos syndrome 4 4 1
ehlers-danlos syndrome, vascular type 4 4 1
Cerebral saccular aneurysm 3 3 5
Nephrosclerosis 3 3 14

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
COL3A1 5 / 5 Cerebral saccular aneurysm, Connective and soft tissue disorder, ehlers-danlos syndrome, vascular type, Nephrosclerosis and 1 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Non-integrin membrane-ECM interactions
COL3A1, COL1A1, FGF2
 Reactome 3 / 24 83.4× 5.61e-6 2.13e-4 ✓ sig.
Relaxin signaling pathway
COL3A1, ACTA2, COL1A1, TGFB1
 KEGG 4 / 130 20.5× 3.57e-5 9.79e-4 ✓ sig.
Intestinal immune network for IgA production
CXCL12, CXCR4, TGFB1
 KEGG 3 / 50 40.0× 5.30e-5 1.36e-3 ✓ sig.
Signaling by ROBO receptors
CXCL12, CXCR4
 Reactome 2 / 12 111× 1.39e-4 2.95e-3 ✓ sig.
Extracellular matrix organization
COL3A1, COL1A1
 Reactome 2 / 15 89.0× 2.20e-4 4.25e-3 ✓ sig.
Syndecan interactions
FGF2, TGFB1
 Reactome 2 / 16 83.4× 2.51e-4 4.73e-3 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
COL3A1, COL1A1, TGFB1
 KEGG 3 / 101 19.8× 4.30e-4 7.24e-3 ✓ sig.
Amoebiasis
COL3A1, COL1A1, TGFB1
 KEGG 3 / 103 19.4× 4.55e-4 7.57e-3 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
ALOX5, FGF2, TGFB1
 Reactome 3 / 108 18.5× 5.23e-4 8.42e-3 ✓ sig.
MET activates PTK2 signaling
COL3A1, COL1A1
 Reactome 2 / 30 44.5× 9.00e-4 1.28e-2 ✓ sig.
Biosynthesis of DPAn-3-derived 13-series resolvins
ALOX5
 Reactome 1 / 1 667× 1.50e-3 1.89e-2 ✓ sig.
Collagen chain trimerization
COL3A1, COL1A1
 Reactome 2 / 44 30.3× 1.93e-3 2.27e-2 ✓ sig.
Assembly of collagen fibrils and other multimeric structures
COL3A1, COL1A1
 Reactome 2 / 51 26.2× 2.59e-3 2.82e-2 ✓ sig.
ECM proteoglycans
COL3A1, COL1A1
 Reactome 2 / 51 26.2× 2.59e-3 2.82e-2 ✓ sig.
Collagen degradation
COL3A1, COL1A1
 Reactome 2 / 52 25.7× 2.69e-3 2.90e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of vasculature development
CXCL12, CXCR4, TGFB1
 GO:1904018 3 / 5 623× 7.49e-9 1.29e-6 ✓ sig.
response to hypoxia
ENG, TGFBR3, CXCL12, CXCR4, MTHFR, TGFB1
 GO:0001666 6 / 176 35.4× 1.08e-8 1.79e-6 ✓ sig.
transforming growth factor beta receptor signaling pathway
COL3A1, ENG, TGFBR3, HIPK2, TGFB1
 GO:0007179 5 / 112 46.3× 5.69e-8 7.54e-6 ✓ sig.
cellular response to transforming growth factor beta stimulus
TGFBR3, ACTA2, COL1A1, TGFB1
 GO:0071560 4 / 67 62.0× 4.45e-7 4.28e-5 ✓ sig.
animal organ regeneration
TGFBR3, CXCL12, TGFB1
 GO:0031100 3 / 28 111× 2.42e-6 1.71e-4 ✓ sig.
positive regulation of SMAD protein signal transduction
ENG, TGFBR3, TGFB1
 GO:0060391 3 / 42 74.2× 8.41e-6 4.66e-4 ✓ sig.
CXCL12-activated CXCR4 signaling pathway
CXCL12, CXCR4
 GO:0038160 2 / 6 346× 1.31e-5 6.54e-4 ✓ sig.
epithelial to mesenchymal transition
TGFBR3, S100A4, TGFB1
 GO:0001837 3 / 61 51.1× 2.61e-5 1.12e-3 ✓ sig.
cellular response to mechanical stimulus
COL1A1, FGF2, TGFB1
 GO:0071260 3 / 76 41.0× 5.05e-5 1.85e-3 ✓ sig.
wound healing
COL3A1, ENG, FGF2
 GO:0042060 3 / 76 41.0× 5.05e-5 1.85e-3 ✓ sig.
cell chemotaxis
ENG, CXCL12, CXCR4
 GO:0060326 3 / 87 35.8× 7.56e-5 2.51e-3 ✓ sig.
negative regulation of wound healing
ALOX5, FGF2
 GO:0061045 2 / 14 148× 7.92e-5 2.60e-3 ✓ sig.
hyaluronan catabolic process
FGF2, TGFB1
 GO:0030214 2 / 16 130× 1.04e-4 3.19e-3 ✓ sig.
positive regulation of cell migration
COL1A1, CXCL12, CXCR4, TGFB1
 GO:0030335 4 / 292 14.2× 1.50e-4 4.19e-3 ✓ sig.
positive regulation of canonical Wnt signaling pathway
COL1A1, FGF2, TGFB1
 GO:0090263 3 / 115 27.1× 1.73e-4 4.65e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Connective and soft tissue disorder Vascular ehlers-danlos syndrome 0.500 1 6.49e-5 2.32e-4 ✓ sig.
Connective and soft tissue disorder ehlers-danlos syndrome, vascular type 0.500 1 6.49e-5 2.32e-4 ✓ sig.
ehlers-danlos syndrome, vascular type Vascular ehlers-danlos syndrome 0.500 1 6.49e-5 2.32e-4 ✓ sig.
Cerebral saccular aneurysm Connective and soft tissue disorder 0.167 1 3.25e-4 7.68e-4 ✓ sig.
Cerebral saccular aneurysm Vascular ehlers-danlos syndrome 0.167 1 3.25e-4 7.68e-4 ✓ sig.
Cerebral saccular aneurysm ehlers-danlos syndrome, vascular type 0.167 1 3.25e-4 7.68e-4 ✓ sig.
Connective and soft tissue disorder Nephrosclerosis 0.067 1 9.09e-4 1.57e-3 ✓ sig.
ehlers-danlos syndrome, vascular type Nephrosclerosis 0.067 1 9.09e-4 1.57e-3 ✓ sig.
Nephrosclerosis Vascular ehlers-danlos syndrome 0.067 1 9.09e-4 1.57e-3 ✓ sig.