Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
← Back to all clusters
Cluster 371
5
Diseases
20
Unique genes
0.169
Avg. similarity score
Anterior compartment syndrome
Most-connected disease (4 links)
Disease
Searched: Anterior compartment syndrome
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) ·
drag a node to pin it in place · scroll/pinch to zoom.
Anterior compartment syndrome
Heme oxygenase deficiency
Hemolysis
Vascular system injury
Intracranial vasospasm
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Anterior compartment syndrome | 4 | 4 | 1 |
| Heme oxygenase deficiency | 4 | 4 | 1 |
| Hemolysis | 3 | 3 | 6 |
| Vascular system injury | 3 | 3 | 10 |
| Intracranial vasospasm | 2 | 2 | 7 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| HMOX1 | 5 / 5 | Anterior compartment syndrome, Heme oxygenase deficiency, Hemolysis, Intracranial vasospasm and 1 more |
| ATP7A | 2 / 5 | Hemolysis, Vascular system injury |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Fluid shear stress and atherosclerosis | KEGG | 4 / 141 | 17.0× | 7.62e-5 | 1.87e-3 ✓ sig. |
| Mineral absorption | KEGG | 3 / 61 | 29.5× | 1.34e-4 | 2.92e-3 ✓ sig. |
| Complement and coagulation cascades | KEGG | 3 / 88 | 20.5× | 3.96e-4 | 6.90e-3 ✓ sig. |
| Chagas disease | KEGG | 3 / 103 | 17.5× | 6.28e-4 | 9.87e-3 ✓ sig. |
| Renin-angiotensin system | KEGG | 2 / 23 | 52.2× | 6.53e-4 | 1.02e-2 ✓ sig. |
| G alpha (i) signalling events | Reactome | 4 / 249 | 9.6× | 6.73e-4 | 1.04e-2 ✓ sig. |
| Peptide ligand-binding receptors | Reactome | 3 / 106 | 17.0× | 6.83e-4 | 1.05e-2 ✓ sig. |
| Interleukin-4 and Interleukin-13 signaling | Reactome | 3 / 108 | 16.7× | 7.21e-4 | 1.10e-2 ✓ sig. |
| Iron uptake and transport | Reactome | 2 / 28 | 42.9× | 9.70e-4 | 1.37e-2 ✓ sig. |
| Sphingolipid signaling pathway | KEGG | 3 / 122 | 14.8× | 1.03e-3 | 1.44e-2 ✓ sig. |
| Signaling by PDGF | Reactome | 2 / 33 | 36.4× | 1.35e-3 | 1.76e-2 ✓ sig. |
| Apelin signaling pathway | KEGG | 3 / 140 | 12.9× | 1.53e-3 | 1.94e-2 ✓ sig. |
| Ferroptosis | KEGG | 2 / 42 | 28.6× | 2.18e-3 | 2.52e-2 ✓ sig. |
| Neuroactive ligand-receptor interaction | KEGG | 4 / 370 | 6.5× | 2.90e-3 | 3.09e-2 ✓ sig. |
| Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | Reactome | 1 / 2 | 300× | 3.33e-3 | 3.39e-2 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| vasodilation | GO:0042311 | 5 / 50 | 93.4× | 1.68e-9 | 3.57e-7 ✓ sig. |
| response to ethanol | GO:0045471 | 4 / 110 | 34.0× | 5.12e-6 | 3.15e-4 ✓ sig. |
| response to macrophage colony-stimulating factor | GO:0036005 | 2 / 4 | 467× | 6.52e-6 | 3.84e-4 ✓ sig. |
| inflammatory response | GO:0006954 | 6 / 467 | 12.0× | 6.79e-6 | 3.97e-4 ✓ sig. |
| response to hydrogen peroxide | GO:0042542 | 3 / 39 | 71.9× | 9.35e-6 | 5.13e-4 ✓ sig. |
| blood vessel remodeling | GO:0001974 | 3 / 42 | 66.7× | 1.17e-5 | 6.11e-4 ✓ sig. |
| positive regulation of smooth muscle cell proliferation | GO:0048661 | 3 / 52 | 53.9× | 2.24e-5 | 1.01e-3 ✓ sig. |
| response to salt stress | GO:0009651 | 2 / 9 | 208× | 3.90e-5 | 1.54e-3 ✓ sig. |
| intracellular iron ion homeostasis | GO:0006879 | 3 / 71 | 39.5× | 5.72e-5 | 2.05e-3 ✓ sig. |
| negative regulation of heart rate | GO:0010459 | 2 / 12 | 156× | 7.14e-5 | 2.43e-3 ✓ sig. |
| regulation of blood pressure | GO:0008217 | 3 / 83 | 33.8× | 9.12e-5 | 2.93e-3 ✓ sig. |
| positive regulation of canonical NF-kappaB signal transduction | GO:0043123 | 4 / 232 | 16.1× | 9.59e-5 | 3.04e-3 ✓ sig. |
| negative regulation of ferroptosis | GO:0110076 | 2 / 14 | 133× | 9.83e-5 | 3.10e-3 ✓ sig. |
| removal of superoxide radicals | GO:0019430 | 2 / 15 | 125× | 1.13e-4 | 3.43e-3 ✓ sig. |
| angiotensin-activated signaling pathway | GO:0038166 | 2 / 16 | 117× | 1.29e-4 | 3.78e-3 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Hemolysis | Vascular system injury | 0.133 | 2 | 5.69e-6 | 2.92e-5 ✓ sig. |
| Anterior compartment syndrome | Heme oxygenase deficiency | 0.500 | 1 | 6.49e-5 | 2.33e-4 ✓ sig. |
| Anterior compartment syndrome | Hemolysis | 0.143 | 1 | 3.90e-4 | 8.67e-4 ✓ sig. |
| Heme oxygenase deficiency | Hemolysis | 0.143 | 1 | 3.90e-4 | 8.67e-4 ✓ sig. |
| Anterior compartment syndrome | Intracranial vasospasm | 0.125 | 1 | 4.55e-4 | 9.73e-4 ✓ sig. |
| Heme oxygenase deficiency | Intracranial vasospasm | 0.125 | 1 | 4.55e-4 | 9.73e-4 ✓ sig. |
| Anterior compartment syndrome | Vascular system injury | 0.091 | 1 | 6.49e-4 | 1.24e-3 ✓ sig. |
| Heme oxygenase deficiency | Vascular system injury | 0.091 | 1 | 6.49e-4 | 1.24e-3 ✓ sig. |