Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 592
5
Diseases
33
Unique genes
0.184
Avg. similarity score
Coronary aneurysm
Most-connected disease (4 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Coronary aneurysm
Carbohydrate deficient glycoprotein syndrome
Mental retardation, autosomal recessive 15
Rafiq syndrome
Dock2 deficiency
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Coronary aneurysm | 4 | 4 | 32 |
| Carbohydrate deficient glycoprotein syndrome | 3 | 3 | 2 |
| Mental retardation, autosomal recessive 15 | 3 | 3 | 1 |
| Rafiq syndrome | 3 | 3 | 1 |
| Dock2 deficiency | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| MAN1B1 | 4 / 5 | Carbohydrate deficient glycoprotein syndrome, Coronary aneurysm, Mental retardation, autosomal recessive 15, Rafiq syndrome |
| DOCK2 | 2 / 5 | Coronary aneurysm, Dock2 deficiency |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | Reactome | 2 / 18 | 40.4× | 1.09e-3 | 1.21e-2 ✓ sig. |
| Defective MAN1B1 causes MRT15 | Reactome | 1 / 1 | 364× | 2.75e-3 | 2.39e-2 ✓ sig. |
| Regulation of gap junction activity | Reactome | 1 / 3 | 121× | 8.22e-3 | 5.04e-2 |
| Assembly and cell surface presentation of NMDA receptors | Reactome | 1 / 6 | 60.7× | 1.64e-2 | 7.63e-2 |
| Nef and signal transduction | Reactome | 1 / 8 | 45.5× | 2.18e-2 | 9.00e-2 |
| Ca2+ activated K+ channels | Reactome | 1 / 9 | 40.4× | 2.45e-2 | 9.63e-2 |
| Gap junction | KEGG | 2 / 89 | 8.2× | 2.47e-2 | 9.67e-2 |
| Formation of annular gap junctions | Reactome | 1 / 11 | 33.1× | 2.98e-2 | 1.08e-1 |
| Calcium signaling pathway | KEGG | 3 / 254 | 4.3× | 3.20e-2 | 1.12e-1 |
| Gap junction degradation | Reactome | 1 / 12 | 30.3× | 3.25e-2 | 1.13e-1 |
| Gap junction assembly | Reactome | 1 / 18 | 20.2× | 4.84e-2 | 1.42e-1 |
| Cilium Assembly | Reactome | 1 / 19 | 19.2× | 5.10e-2 | 1.46e-1 |
| ER Quality Control Compartment (ERQC) | Reactome | 1 / 21 | 17.3× | 5.62e-2 | 1.55e-1 |
| Carboxyterminal post-translational modifications of tubulin | Reactome | 1 / 27 | 13.5× | 7.17e-2 | 1.78e-1 |
| Synthesis of IP3 and IP4 in the cytosol | Reactome | 1 / 28 | 13.0× | 7.42e-2 | 1.82e-1 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| prepulse inhibition | GO:0060134 | 2 / 14 | 80.9× | 2.72e-4 | 6.31e-3 ✓ sig. |
| cochlea morphogenesis | GO:0090103 | 2 / 28 | 40.4× | 1.11e-3 | 1.55e-2 ✓ sig. |
| regulation of granulocyte chemotaxis | GO:0071622 | 1 / 1 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| regulation of systemic arterial blood pressure by baroreceptor feedback | GO:0003025 | 1 / 1 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| glossopharyngeal nerve development | GO:0021563 | 1 / 1 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| vagus nerve development | GO:0021564 | 1 / 1 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| microtubule-based transport | GO:0099111 | 1 / 1 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| protein alpha-1,2-demannosylation | GO:0036508 | 1 / 1 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| Golgi calcium ion homeostasis | GO:0032468 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
| Golgi calcium ion transport | GO:0032472 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
| negative regulation of endothelial cell-matrix adhesion via fibronectin | GO:1904905 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
| negative regulation of gonadotropin secretion | GO:0032277 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
| positive regulation of morphogenesis of an epithelium | GO:1905332 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
| cellular response to Thyroid stimulating hormone | GO:1904401 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
| regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator | GO:1902238 | 1 / 2 | 283× | 3.53e-3 | 2.82e-2 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Mental retardation, autosomal recessive 15 | Rafiq syndrome | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Carbohydrate deficient glycoprotein syndrome | Mental retardation, autosomal recessive 15 | 0.333 | 1 | 1.29e-4 | 3.27e-4 ✓ sig. |
| Carbohydrate deficient glycoprotein syndrome | Rafiq syndrome | 0.333 | 1 | 1.29e-4 | 3.27e-4 ✓ sig. |
| Coronary aneurysm | Dock2 deficiency | 0.030 | 1 | 2.07e-3 | 2.79e-3 ✓ sig. |
| Coronary aneurysm | Mental retardation, autosomal recessive 15 | 0.030 | 1 | 2.07e-3 | 2.79e-3 ✓ sig. |
| Coronary aneurysm | Rafiq syndrome | 0.030 | 1 | 2.07e-3 | 2.79e-3 ✓ sig. |
| Carbohydrate deficient glycoprotein syndrome | Coronary aneurysm | 0.029 | 1 | 4.13e-3 | 5.06e-3 ✓ sig. |