Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 587
5
Diseases
7
Unique genes
0.258
Avg. similarity score
Bleeding esophageal varices
Most-connected disease (4 links)
Disease
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Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Bleeding esophageal varices
Esophageal and gastric varices
Esophageal varices
Sweat gland disease
Vipoma
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Bleeding esophageal varices | 4 | 4 | 1 |
| Esophageal and gastric varices | 4 | 4 | 1 |
| Esophageal varices | 4 | 4 | 4 |
| Sweat gland disease | 4 | 4 | 2 |
| Vipoma | 4 | 4 | 3 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| SST | 5 / 5 | Bleeding esophageal varices, Esophageal and gastric varices, Esophageal varices, Sweat gland disease and 1 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Acyl chain remodeling of DAG and TAG | Reactome | 1 / 7 | 245× | 4.07e-3 | 3.17e-2 ✓ sig. |
| Regulation of IFNA signaling | Reactome | 1 / 24 | 71.5× | 1.39e-2 | 6.94e-2 |
| TRAF6 mediated IRF7 activation | Reactome | 1 / 29 | 59.2× | 1.68e-2 | 7.75e-2 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Reactome | 1 / 32 | 53.6× | 1.85e-2 | 8.20e-2 |
| RHO GTPases activate IQGAPs | Reactome | 1 / 32 | 53.6× | 1.85e-2 | 8.20e-2 |
| Deactivation of the beta-catenin transactivating complex | Reactome | 1 / 42 | 40.9× | 2.42e-2 | 9.58e-2 |
| Autoimmune thyroid disease | KEGG | 1 / 54 | 31.8× | 3.11e-2 | 1.10e-1 |
| Glycerolipid metabolism | KEGG | 1 / 64 | 26.8× | 3.67e-2 | 1.21e-1 |
| Interferon alpha/beta signaling | Reactome | 1 / 67 | 25.6× | 3.84e-2 | 1.25e-1 |
| RIG-I-like receptor signaling pathway | KEGG | 1 / 72 | 23.8× | 4.12e-2 | 1.30e-1 |
| Gastric acid secretion | KEGG | 1 / 76 | 22.6× | 4.35e-2 | 1.34e-1 |
| Cytosolic DNA-sensing pathway | KEGG | 1 / 83 | 20.7× | 4.74e-2 | 1.40e-1 |
| Formation of the beta-catenin:TCF transactivating complex | Reactome | 1 / 88 | 19.5× | 5.02e-2 | 1.45e-1 |
| Factors involved in megakaryocyte development and platelet production | Reactome | 1 / 99 | 17.3× | 5.63e-2 | 1.55e-1 |
| Peptide ligand-binding receptors | Reactome | 1 / 106 | 16.2× | 6.02e-2 | 1.61e-1 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| lipid homeostasis | GO:0055088 | 2 / 55 | 97.1× | 1.77e-4 | 4.66e-3 ✓ sig. |
| triglyceride acyl-chain remodeling | GO:0036153 | 1 / 1 | 2,670× | 3.75e-4 | 7.81e-3 ✓ sig. |
| cellular response to 3,3',5-triiodo-L-thyronine | GO:1905243 | 1 / 2 | 1,335× | 7.49e-4 | 1.23e-2 ✓ sig. |
| acylglycerol acyl-chain remodeling | GO:0036155 | 1 / 4 | 667× | 1.50e-3 | 1.82e-2 ✓ sig. |
| response to sucrose | GO:0009744 | 1 / 5 | 534× | 1.87e-3 | 2.05e-2 ✓ sig. |
| hormone-mediated apoptotic signaling pathway | GO:0008628 | 1 / 5 | 534× | 1.87e-3 | 2.05e-2 ✓ sig. |
| somatostatin signaling pathway | GO:0038170 | 1 / 6 | 445× | 2.25e-3 | 2.24e-2 ✓ sig. |
| hyperosmotic response | GO:0006972 | 1 / 8 | 334× | 2.99e-3 | 2.59e-2 ✓ sig. |
| T-helper 2 cell differentiation | GO:0045064 | 1 / 9 | 297× | 3.37e-3 | 2.76e-2 ✓ sig. |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity | GO:0045736 | 1 / 9 | 297× | 3.37e-3 | 2.76e-2 ✓ sig. |
| response to acidic pH | GO:0010447 | 1 / 12 | 222× | 4.49e-3 | 3.17e-2 ✓ sig. |
| glycerophospholipid metabolic process | GO:0006650 | 1 / 15 | 178× | 5.61e-3 | 3.51e-2 ✓ sig. |
| osteoblast development | GO:0002076 | 1 / 16 | 167× | 5.98e-3 | 3.62e-2 ✓ sig. |
| B cell activation involved in immune response | GO:0002312 | 1 / 17 | 157× | 6.35e-3 | 3.73e-2 ✓ sig. |
| lipid droplet organization | GO:0034389 | 1 / 18 | 148× | 6.72e-3 | 3.84e-2 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Bleeding esophageal varices | Esophageal and gastric varices | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Bleeding esophageal varices | Sweat gland disease | 0.333 | 1 | 1.29e-4 | 3.27e-4 ✓ sig. |
| Esophageal and gastric varices | Sweat gland disease | 0.333 | 1 | 1.29e-4 | 3.27e-4 ✓ sig. |
| Bleeding esophageal varices | Vipoma | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Esophageal and gastric varices | Vipoma | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Bleeding esophageal varices | Esophageal varices | 0.200 | 1 | 2.58e-4 | 5.38e-4 ✓ sig. |
| Esophageal and gastric varices | Esophageal varices | 0.200 | 1 | 2.58e-4 | 5.38e-4 ✓ sig. |
| Sweat gland disease | Vipoma | 0.200 | 1 | 3.87e-4 | 7.33e-4 ✓ sig. |
| Esophageal varices | Sweat gland disease | 0.167 | 1 | 5.16e-4 | 9.13e-4 ✓ sig. |
| Esophageal varices | Vipoma | 0.143 | 1 | 7.75e-4 | 1.25e-3 ✓ sig. |