Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 340
6
Diseases
11
Unique genes
0.247
Avg. similarity score
Sweat gland disease
Most-connected disease (5 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Sweat gland disease
Bleeding esophageal varices
Esophageal and gastric varices
Esophageal varices
Vipoma
Dyshidrosis
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Sweat gland disease | 5 | 5 | 2 |
| Bleeding esophageal varices | 4 | 4 | 1 |
| Esophageal and gastric varices | 4 | 4 | 1 |
| Esophageal varices | 4 | 4 | 4 |
| Vipoma | 4 | 4 | 3 |
| Dyshidrosis | 1 | 1 | 5 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| SST | 5 / 6 | Bleeding esophageal varices, Esophageal and gastric varices, Esophageal varices, Sweat gland disease and 1 more |
| TCERG1L | 2 / 6 | Dyshidrosis, Sweat gland disease |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
None of these pathways reaches significance (all FDR q ≥ 0.05). They’re the best candidates found, but treat them as weak evidence for why this cluster groups together.
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Acyl chain remodeling of DAG and TAG | Reactome | 1 / 7 | 156× | 6.40e-3 | 5.15e-2 |
| Receptor-type tyrosine-protein phosphatases | Reactome | 1 / 20 | 54.6× | 1.82e-2 | 9.77e-2 |
| Synaptic adhesion-like molecules | Reactome | 1 / 21 | 52.0× | 1.91e-2 | 1.00e-1 |
| Unblocking of NMDA receptors, glutamate binding and activation | Reactome | 1 / 22 | 49.6× | 2.00e-2 | 1.03e-1 |
| Regulation of IFNA signaling | Reactome | 1 / 24 | 45.5× | 2.18e-2 | 1.08e-1 |
| TRAF6 mediated IRF7 activation | Reactome | 1 / 29 | 37.6× | 2.63e-2 | 1.20e-1 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Reactome | 1 / 32 | 34.1× | 2.89e-2 | 1.26e-1 |
| RHO GTPases activate IQGAPs | Reactome | 1 / 32 | 34.1× | 2.89e-2 | 1.26e-1 |
| Neurexins and neuroligins | Reactome | 1 / 32 | 34.1× | 2.89e-2 | 1.26e-1 |
| Human papillomavirus infection | KEGG | 2 / 333 | 6.6× | 3.57e-2 | 1.43e-1 |
| Deactivation of the beta-catenin transactivating complex | Reactome | 1 / 42 | 26.0× | 3.78e-2 | 1.47e-1 |
| Autoimmune thyroid disease | KEGG | 1 / 54 | 20.2× | 4.84e-2 | 1.68e-1 |
| Glycerolipid metabolism | KEGG | 1 / 64 | 17.1× | 5.71e-2 | 1.84e-1 |
| Interferon alpha/beta signaling | Reactome | 1 / 67 | 16.3× | 5.97e-2 | 1.88e-1 |
| RIG-I-like receptor signaling pathway | KEGG | 1 / 72 | 15.2× | 6.40e-2 | 1.95e-1 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| regulation of postsynaptic membrane neurotransmitter receptor levels | GO:0099072 | 2 / 32 | 106× | 1.55e-4 | 4.19e-3 ✓ sig. |
| lipid homeostasis | GO:0055088 | 2 / 55 | 61.8× | 4.60e-4 | 9.04e-3 ✓ sig. |
| triglyceride acyl-chain remodeling | GO:0036153 | 1 / 1 | 1,699× | 5.89e-4 | 1.07e-2 ✓ sig. |
| retrograde axonal protein transport | GO:0099642 | 1 / 2 | 849× | 1.18e-3 | 1.66e-2 ✓ sig. |
| cellular response to 3,3',5-triiodo-L-thyronine | GO:1905243 | 1 / 2 | 849× | 1.18e-3 | 1.66e-2 ✓ sig. |
| trans-synaptic signaling by trans-synaptic complex | GO:0099545 | 1 / 3 | 566× | 1.76e-3 | 2.11e-2 ✓ sig. |
| trans-synaptic signaling | GO:0099537 | 1 / 4 | 425× | 2.35e-3 | 2.48e-2 ✓ sig. |
| acylglycerol acyl-chain remodeling | GO:0036155 | 1 / 4 | 425× | 2.35e-3 | 2.48e-2 ✓ sig. |
| response to sucrose | GO:0009744 | 1 / 5 | 340× | 2.94e-3 | 2.79e-2 ✓ sig. |
| positive regulation of microvillus assembly | GO:1903698 | 1 / 5 | 340× | 2.94e-3 | 2.79e-2 ✓ sig. |
| hormone-mediated apoptotic signaling pathway | GO:0008628 | 1 / 5 | 340× | 2.94e-3 | 2.79e-2 ✓ sig. |
| MAPK cascade | GO:0000165 | 2 / 147 | 23.1× | 3.23e-3 | 2.93e-2 ✓ sig. |
| somatostatin signaling pathway | GO:0038170 | 1 / 6 | 283× | 3.53e-3 | 3.08e-2 ✓ sig. |
| cell surface receptor protein tyrosine phosphatase signaling pathway | GO:0007185 | 1 / 7 | 243× | 4.11e-3 | 3.32e-2 ✓ sig. |
| GDP metabolic process | GO:0046710 | 1 / 8 | 212× | 4.70e-3 | 3.56e-2 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Bleeding esophageal varices | Esophageal and gastric varices | 0.500 | 1 | 6.49e-5 | 2.34e-4 ✓ sig. |
| Bleeding esophageal varices | Sweat gland disease | 0.333 | 1 | 1.30e-4 | 3.90e-4 ✓ sig. |
| Esophageal and gastric varices | Sweat gland disease | 0.333 | 1 | 1.30e-4 | 3.90e-4 ✓ sig. |
| Bleeding esophageal varices | Vipoma | 0.250 | 1 | 1.95e-4 | 5.28e-4 ✓ sig. |
| Esophageal and gastric varices | Vipoma | 0.250 | 1 | 1.95e-4 | 5.28e-4 ✓ sig. |
| Bleeding esophageal varices | Esophageal varices | 0.200 | 1 | 2.60e-4 | 6.40e-4 ✓ sig. |
| Esophageal and gastric varices | Esophageal varices | 0.200 | 1 | 2.60e-4 | 6.40e-4 ✓ sig. |
| Sweat gland disease | Vipoma | 0.200 | 1 | 3.90e-4 | 8.52e-4 ✓ sig. |
| Esophageal varices | Sweat gland disease | 0.167 | 1 | 5.19e-4 | 1.04e-3 ✓ sig. |
| Dyshidrosis | Sweat gland disease | 0.143 | 1 | 6.49e-4 | 1.22e-3 ✓ sig. |
| Esophageal varices | Vipoma | 0.143 | 1 | 7.79e-4 | 1.39e-3 ✓ sig. |