Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 330
6
Diseases
29
Unique genes
0.226
Avg. similarity score
Autoimmune hemolytic anemia
Most-connected disease (4 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Autoimmune hemolytic anemia
Autoimmunity-autoinflammation-immunodeficiency syndrome
Autoinflammatory syndrome with immunodeficiency
Autoinflammatory syndrome, familial, with or without immunodeficiency
Autoimmune thrombocytopenic purpura
Degenerative polyarthritis
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Autoimmune hemolytic anemia | 4 | 4 | 5 |
| Autoimmunity-autoinflammation-immunodeficiency syndrome | 4 | 4 | 1 |
| Autoinflammatory syndrome with immunodeficiency | 4 | 4 | 1 |
| Autoinflammatory syndrome, familial, with or without immunodeficiency | 4 | 4 | 1 |
| Autoimmune thrombocytopenic purpura | 3 | 3 | 24 |
| Degenerative polyarthritis | 1 | 1 | 2 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| SOCS1 | 5 / 6 | Autoimmune hemolytic anemia, Autoimmune thrombocytopenic purpura, Autoimmunity-autoinflammation-immunodeficiency syndrome, Autoinflammatory syndrome with immunodeficiency and 1 more |
| TLR8 | 2 / 6 | Autoimmune hemolytic anemia, Degenerative polyarthritis |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of Wnt signaling pathway, planar cell polarity pathway | GO:2000096 | 2 / 9 | 143× | 8.32e-5 | 2.64e-3 ✓ sig. |
| negative regulation of Wnt signaling pathway | GO:0030178 | 3 / 61 | 31.7× | 1.14e-4 | 3.33e-3 ✓ sig. |
| regulation of systemic arterial blood pressure by baroreceptor feedback | GO:0003025 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| glossopharyngeal nerve development | GO:0021563 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| vagus nerve development | GO:0021564 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| cyclic purine nucleotide metabolic process | GO:0052652 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| regulation of endodermal cell fate specification | GO:0042663 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| positive regulation of Wnt signaling pathway, calcium modulating pathway | GO:0045813 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| negative regulation of Wnt-Frizzled-LRP5/6 complex assembly | GO:1904723 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| positive regulation of midbrain dopaminergic neuron differentiation | GO:1904958 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| negative regulation of presynapse assembly | GO:1905607 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| serine family amino acid catabolic process | GO:0009071 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| 2-oxobutyrate biosynthetic process | GO:0046360 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| negative regulation of hepatocyte differentiation | GO:0070367 | 1 / 1 | 644× | 1.55e-3 | 1.95e-2 ✓ sig. |
| negative regulation of canonical Wnt signaling pathway | GO:0090090 | 3 / 150 | 12.9× | 1.59e-3 | 1.98e-2 ✓ sig. |