Disease Clusters | GeDiPNet

← Back to all clusters

Cluster 314

6 diseases · 15 shared-gene connections

6 Diseases

3 Unique genes

0.417 Avg. similarity score

Analbuminemia Most-connected disease (5 links)

Significant edges only (q < 0.05) Spacing Colour by

Disease Pinned (dragged)

Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Analbuminemia Anuria Blood protein disorder Congenital analbuminemia Dysalbuminemic hyperthyroxinemia hyperthyroxinemia, familial dysalbuminemic

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵	Connections in cluster ⇵	Significant partners ⇵	Curated genes ⇵
Analbuminemia	5	5	1
Anuria	5	5	3
Blood protein disorder	5	5	1
Congenital analbuminemia	5	5	1
Dysalbuminemic hyperthyroxinemia	5	5	1
hyperthyroxinemia, familial dysalbuminemic	5	5	1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵	Member diseases ⇵	Linked diseases
ALB	6 / 6	Analbuminemia, Anuria, Blood protein disorder, Congenital analbuminemia and 2 more

What do these columns mean?

Connections in cluster: How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners: How many of those links are statistically significant (FDR q < 0.05).
Curated genes: Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes): How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y): x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count: Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment: Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value: Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster): Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster): Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵	Source ⇵	Overlap genes ⇵	Fold enrichment ⇵	P-value ⇵	FDR q-value ⇵
HDL remodeling ALB	Reactome	1 / 10	400×	2.50e-3	2.69e-2 ✓ sig.
Transport of organic anions ALB	Reactome	1 / 12	334×	2.99e-3	3.07e-2 ✓ sig.
Scavenging of heme from plasma ALB	Reactome	1 / 13	308×	3.24e-3	3.26e-2 ✓ sig.
Dissolution of Fibrin Clot PLAU	Reactome	1 / 13	308×	3.24e-3	3.26e-2 ✓ sig.
Heme degradation ALB	Reactome	1 / 14	286×	3.49e-3	3.42e-2 ✓ sig.
Heme biosynthesis ALB	Reactome	1 / 14	286×	3.49e-3	3.42e-2 ✓ sig.
Recycling of bile acids and salts ALB	Reactome	1 / 16	250×	3.99e-3	3.77e-2 ✓ sig.
Metabolism of Angiotensinogen to Angiotensins AGT	Reactome	1 / 17	235×	4.24e-3	3.93e-2 ✓ sig.
Renin-angiotensin system AGT	KEGG	1 / 23	174×	5.73e-3	4.80e-2 ✓ sig.
Cortisol synthesis and secretion AGT	KEGG	1 / 65	61.6×	1.62e-2	9.11e-2
Renin secretion AGT	KEGG	1 / 69	58.0×	1.71e-2	9.46e-2
Thyroid hormone synthesis ALB	KEGG	1 / 75	53.4×	1.86e-2	9.87e-2
Complement and coagulation cascades PLAU	KEGG	1 / 88	45.5×	2.18e-2	1.08e-1
Aldosterone synthesis and secretion AGT	KEGG	1 / 98	40.9×	2.43e-2	1.15e-1
Prostate cancer PLAU	KEGG	1 / 98	40.9×	2.43e-2	1.15e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵	GO ID ⇵	Overlap genes ⇵	Fold enrichment ⇵	P-value ⇵	FDR q-value ⇵
positive regulation of epidermal growth factor receptor signaling pathway AGT, PLAU	GO:0045742	2 / 32	389×	8.51e-6	4.60e-4 ✓ sig.
regulation of smooth muscle cell-matrix adhesion PLAU	GO:2000097	1 / 1	6,229×	1.61e-4	4.31e-3 ✓ sig.
regulation of renal output by angiotensin AGT	GO:0002019	1 / 2	3,115×	3.21e-4	7.03e-3 ✓ sig.
regulation of blood volume by renin-angiotensin AGT	GO:0002016	1 / 2	3,115×	3.21e-4	7.03e-3 ✓ sig.
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger AGT	GO:0007199	1 / 2	3,115×	3.21e-4	7.03e-3 ✓ sig.
positive regulation of membrane hyperpolarization AGT	GO:1902632	1 / 2	3,115×	3.21e-4	7.03e-3 ✓ sig.
regulation of cell population proliferation AGT, PLAU	GO:0042127	2 / 201	62.0×	3.43e-4	7.36e-3 ✓ sig.
renin-angiotensin regulation of aldosterone production AGT	GO:0002018	1 / 3	2,076×	4.82e-4	9.31e-3 ✓ sig.
regulation of renal sodium excretion AGT	GO:0035813	1 / 3	2,076×	4.82e-4	9.31e-3 ✓ sig.
positive regulation of angiotensin-activated signaling pathway AGT	GO:0110063	1 / 3	2,076×	4.82e-4	9.31e-3 ✓ sig.
regulation of plasminogen activation PLAU	GO:0010755	1 / 3	2,076×	4.82e-4	9.31e-3 ✓ sig.
urokinase plasminogen activator signaling pathway PLAU	GO:0038195	1 / 3	2,076×	4.82e-4	9.31e-3 ✓ sig.
response to muscle activity involved in regulation of muscle adaptation AGT	GO:0014873	1 / 4	1,557×	6.42e-4	1.13e-2 ✓ sig.
negative regulation of neurotrophin TRK receptor signaling pathway AGT	GO:0051387	1 / 4	1,557×	6.42e-4	1.13e-2 ✓ sig.
regulation of extracellular matrix assembly AGT	GO:1901201	1 / 4	1,557×	6.42e-4	1.13e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵	Disease B ⇵	Similarity score ⇵	Shared genes ⇵	P-value ⇵	FDR q-value ⇵
Analbuminemia	Blood protein disorder	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Analbuminemia	Congenital analbuminemia	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Analbuminemia	Dysalbuminemic hyperthyroxinemia	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Analbuminemia	hyperthyroxinemia, familial dysalbuminemic	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Blood protein disorder	Congenital analbuminemia	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Blood protein disorder	Dysalbuminemic hyperthyroxinemia	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Blood protein disorder	hyperthyroxinemia, familial dysalbuminemic	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Congenital analbuminemia	Dysalbuminemic hyperthyroxinemia	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Congenital analbuminemia	hyperthyroxinemia, familial dysalbuminemic	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Dysalbuminemic hyperthyroxinemia	hyperthyroxinemia, familial dysalbuminemic	0.500	1	6.49e-5	2.34e-4 ✓ sig.
Analbuminemia	Anuria	0.250	1	1.95e-4	5.28e-4 ✓ sig.
Anuria	Blood protein disorder	0.250	1	1.95e-4	5.28e-4 ✓ sig.
Anuria	Congenital analbuminemia	0.250	1	1.95e-4	5.28e-4 ✓ sig.
Anuria	Dysalbuminemic hyperthyroxinemia	0.250	1	1.95e-4	5.28e-4 ✓ sig.
Anuria	hyperthyroxinemia, familial dysalbuminemic	0.250	1	1.95e-4	5.28e-4 ✓ sig.

Disease Clusters?