Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 274
7
Diseases
2
Unique genes
0.458
Avg. similarity score
Donohue syndrome
Most-connected disease (6 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Donohue syndrome
Insulin resistant diabetes mellitus with acanthosis nigricans
Insulin-resistant diabetes mellitus with acanthosis nigricans
Leprechaunism syndrome
Type a insulin resistance syndrome
Insulin resistant diabetes mellitus
insulin-resistance syndrome type A
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Donohue syndrome | 6 | 6 | 1 |
| Insulin resistant diabetes mellitus with acanthosis nigricans | 6 | 6 | 1 |
| Insulin-resistant diabetes mellitus with acanthosis nigricans | 6 | 6 | 1 |
| Leprechaunism syndrome | 6 | 6 | 1 |
| Type a insulin resistance syndrome | 6 | 6 | 1 |
| Insulin resistant diabetes mellitus | 5 | 5 | 2 |
| insulin-resistance syndrome type A | 5 | 5 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| INSR | 7 / 7 | Donohue syndrome, Insulin resistant diabetes mellitus, Insulin resistant diabetes mellitus with acanthosis nigricans, insulin-resistance syndrome type A and 3 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Signaling by Insulin receptor | Reactome | 1 / 2 | 3,003× | 3.33e-4 | 5.82e-3 ✓ sig. |
| IRS activation | Reactome | 1 / 5 | 1,201× | 8.33e-4 | 1.18e-2 ✓ sig. |
| Insulin receptor signalling cascade | Reactome | 1 / 6 | 1,001× | 9.99e-4 | 1.35e-2 ✓ sig. |
| Signal attenuation | Reactome | 1 / 10 | 601× | 1.66e-3 | 2.00e-2 ✓ sig. |
| Maturity onset diabetes of the young | KEGG | 1 / 26 | 231× | 4.33e-3 | 3.98e-2 ✓ sig. |
| Insulin receptor recycling | Reactome | 1 / 26 | 231× | 4.33e-3 | 3.98e-2 ✓ sig. |
| Aldosterone-regulated sodium reabsorption | KEGG | 1 / 38 | 158× | 6.32e-3 | 5.11e-2 |
| Type II diabetes mellitus | KEGG | 1 / 47 | 128× | 7.81e-3 | 5.88e-2 |
| Ovarian steroidogenesis | KEGG | 1 / 52 | 115× | 8.64e-3 | 6.28e-2 |
| Regulation of lipolysis in adipocytes | KEGG | 1 / 59 | 102× | 9.80e-3 | 6.78e-2 |
| Longevity regulating pathway - multiple species | KEGG | 1 / 62 | 96.9× | 1.03e-2 | 7.00e-2 |
| Longevity regulating pathway | KEGG | 1 / 90 | 66.7× | 1.49e-2 | 8.67e-2 |
| Adherens junction | KEGG | 1 / 93 | 64.6× | 1.54e-2 | 8.85e-2 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Reactome | 1 / 103 | 58.3× | 1.71e-2 | 9.45e-2 |
| Insulin resistance | KEGG | 1 / 109 | 55.1× | 1.81e-2 | 9.75e-2 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| glucose homeostasis | GO:0042593 | 2 / 134 | 139× | 5.10e-5 | 1.83e-3 ✓ sig. |
| regulation of pronephros size | GO:0035565 | 1 / 2 | 4,672× | 2.14e-4 | 5.28e-3 ✓ sig. |
| positive regulation of meiotic cell cycle | GO:0051446 | 1 / 2 | 4,672× | 2.14e-4 | 5.28e-3 ✓ sig. |
| regulation of female gonad development | GO:2000194 | 1 / 2 | 4,672× | 2.14e-4 | 5.28e-3 ✓ sig. |
| renal D-glucose absorption | GO:0035623 | 1 / 3 | 3,115× | 3.21e-4 | 7.03e-3 ✓ sig. |
| positive regulation of protein-containing complex disassembly | GO:0043243 | 1 / 4 | 2,336× | 4.28e-4 | 8.59e-3 ✓ sig. |
| positive regulation of developmental growth | GO:0048639 | 1 / 4 | 2,336× | 4.28e-4 | 8.59e-3 ✓ sig. |
| positive regulation of respiratory burst | GO:0060267 | 1 / 7 | 1,335× | 7.49e-4 | 1.25e-2 ✓ sig. |
| exocrine pancreas development | GO:0031017 | 1 / 10 | 934× | 1.07e-3 | 1.57e-2 ✓ sig. |
| dendritic spine maintenance | GO:0097062 | 1 / 11 | 849× | 1.18e-3 | 1.66e-2 ✓ sig. |
| regulation of glycogen biosynthetic process | GO:0005979 | 1 / 11 | 849× | 1.18e-3 | 1.66e-2 ✓ sig. |
| male sex determination | GO:0030238 | 1 / 12 | 779× | 1.28e-3 | 1.75e-2 ✓ sig. |
| neuron projection maintenance | GO:1990535 | 1 / 13 | 719× | 1.39e-3 | 1.84e-2 ✓ sig. |
| positive regulation of cellular component organization | GO:0051130 | 1 / 16 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 2 / 778 | 24.0× | 1.73e-3 | 2.09e-2 ✓ sig. |