Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 266

7 diseases · 11 shared-gene connections
7 Diseases
9 Unique genes
0.253 Avg. similarity score
Blast crisis Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Blast crisis 5 5 2
Hyper-immunoglobulin m syndrome 4 4 4
Hyper-immunoglobulin syndrome 4 4 2
hyper-IgM syndrome type 2 3 3 1
Chromosome 22q11.2 microdeletion syndrome 2 2 3
Myelogenous leukemia 2 2 3
hyper-IgM syndrome type 3 2 2 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
AICDA 4 / 7 Blast crisis, hyper-IgM syndrome type 2, Hyper-immunoglobulin m syndrome, Hyper-immunoglobulin syndrome
BCR 3 / 7 Blast crisis, Chromosome 22q11.2 microdeletion syndrome, Myelogenous leukemia
CD40 3 / 7 hyper-IgM syndrome type 3, Hyper-immunoglobulin m syndrome, Hyper-immunoglobulin syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Primary immunodeficiency
AICDA, CD40, CD40LG, UNG
 KEGG 4 / 38 140× 1.06e-8 9.18e-7 ✓ sig.
Chronic myeloid leukemia
BCR, ABL1, CRKL, MAPK1
 KEGG 4 / 77 69.3× 1.92e-7 1.16e-5 ✓ sig.
Intestinal immune network for IgA production
AICDA, CD40, CD40LG
 KEGG 3 / 50 80.1× 5.60e-6 2.08e-4 ✓ sig.
Viral myocarditis
ABL1, CD40, CD40LG
 KEGG 3 / 70 57.2× 1.55e-5 4.85e-4 ✓ sig.
ErbB signaling pathway
ABL1, CRKL, MAPK1
 KEGG 3 / 86 46.6× 2.89e-5 8.08e-4 ✓ sig.
Frs2-mediated activation
CRKL, MAPK1
 Reactome 2 / 12 222× 3.28e-5 9.00e-4 ✓ sig.
Toxoplasmosis
MAPK1, CD40, CD40LG
 KEGG 3 / 112 35.7× 6.37e-5 1.55e-3 ✓ sig.
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
CD40, CD40LG
 Reactome 2 / 18 148× 7.59e-5 1.79e-3 ✓ sig.
Neurotrophin signaling pathway
ABL1, CRKL, MAPK1
 KEGG 3 / 120 33.4× 7.82e-5 1.83e-3 ✓ sig.
Asthma
CD40, CD40LG
 KEGG 2 / 32 83.4× 2.45e-4 4.58e-3 ✓ sig.
RHO GTPases Activate WASPs and WAVEs
ABL1, MAPK1
 Reactome 2 / 36 74.1× 3.10e-4 5.51e-3 ✓ sig.
Allograft rejection
CD40, CD40LG
 KEGG 2 / 39 68.4× 3.65e-4 6.25e-3 ✓ sig.
Pathways in cancer
BCR, ABL1, CRKL, MAPK1
 KEGG 4 / 533 10.0× 4.04e-4 6.76e-3 ✓ sig.
Lipid and atherosclerosis
MAPK1, CD40, CD40LG
 KEGG 3 / 216 18.5× 4.45e-4 7.28e-3 ✓ sig.
Malaria
CD40, CD40LG
 KEGG 2 / 50 53.4× 6.00e-4 9.19e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
isotype switching
AICDA, CD40LG, UNG
 GO:0045190 3 / 19 328× 7.46e-8 9.43e-6 ✓ sig.
B cell proliferation
ABL1, CD40, CD40LG
 GO:0042100 3 / 38 164× 6.46e-7 5.80e-5 ✓ sig.
cellular response to lipopolysaccharide
AICDA, BCR, ABL1, CD40
 GO:0071222 4 / 187 44.4× 1.18e-6 9.44e-5 ✓ sig.
thymus development
ABL1, CRKL, MAPK1
 GO:0048538 3 / 50 125× 1.50e-6 1.14e-4 ✓ sig.
regulation of immunoglobulin production
CD40, CD40LG
 GO:0002637 2 / 9 461× 7.41e-6 4.11e-4 ✓ sig.
CD40 signaling pathway
CD40, CD40LG
 GO:0023035 2 / 10 415× 9.26e-6 4.92e-4 ✓ sig.
Bergmann glial cell differentiation
ABL1, MAPK1
 GO:0060020 2 / 11 378× 1.13e-5 5.73e-4 ✓ sig.
somatic hypermutation of immunoglobulin genes
AICDA, UNG
 GO:0016446 2 / 14 297× 1.87e-5 8.50e-4 ✓ sig.
T cell receptor signaling pathway
ABL1, CRKL, MAPK1
 GO:0050852 3 / 121 51.5× 2.16e-5 9.55e-4 ✓ sig.
regulation of gene expression
ABL1, CRKL, CD40, CD40LG
 GO:0010468 4 / 402 20.7× 2.44e-5 1.04e-3 ✓ sig.
intracellular signal transduction
BCR, ABL1, CRKL, MAPK1
 GO:0035556 4 / 471 17.6× 4.54e-5 1.68e-3 ✓ sig.
positive regulation of macromolecule biosynthetic process
ABL1, CD40
 GO:0010557 2 / 29 143× 8.32e-5 2.64e-3 ✓ sig.
positive regulation of endothelial cell apoptotic process
CD40, CD40LG
 GO:2000353 2 / 29 143× 8.32e-5 2.64e-3 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
ABL1, CD40, CD40LG
 GO:0043123 3 / 232 26.8× 1.50e-4 4.10e-3 ✓ sig.
positive regulation of interleukin-12 production
CD40, CD40LG
 GO:0032735 2 / 43 96.6× 1.84e-4 4.77e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hyper-immunoglobulin m syndrome Hyper-immunoglobulin syndrome 0.400 2 5.06e-8 3.92e-7 ✓ sig.
Blast crisis hyper-IgM syndrome type 2 0.333 1 1.30e-4 3.90e-4 ✓ sig.
hyper-IgM syndrome type 2 Hyper-immunoglobulin syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
hyper-IgM syndrome type 3 Hyper-immunoglobulin syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Blast crisis Hyper-immunoglobulin syndrome 0.250 1 2.60e-4 6.40e-4 ✓ sig.
hyper-IgM syndrome type 2 Hyper-immunoglobulin m syndrome 0.200 1 2.60e-4 6.40e-4 ✓ sig.
hyper-IgM syndrome type 3 Hyper-immunoglobulin m syndrome 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Blast crisis Myelogenous leukemia 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Blast crisis Chromosome 22q11.2 microdeletion syndrome 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Blast crisis Hyper-immunoglobulin m syndrome 0.167 1 5.19e-4 1.04e-3 ✓ sig.
Chromosome 22q11.2 microdeletion syndrome Myelogenous leukemia 0.167 1 5.84e-4 1.14e-3 ✓ sig.