NR1I3 (nuclear receptor subfamily 1 group I member 3)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 9970
Gene name Nuclear receptor subfamily 1 group I member 3
Gene symbol NR1I3
Synonyms (NCBI Gene)
CARCAR1MB67
Chromosome 1
Chromosome location 1q23.3
Summary This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target g
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
RARA Activation 20211151
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 11114890
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding TAS 9783588
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603881 7969 ENSG00000143257
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14994
Protein name Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Protein function Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene
PDB 1XV9 , 1XVP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00105 zf-C4 9 → 78 Zinc finger, C4 type (two domains) Domain
PF00104 Hormone_recep 157 → 338 Ligand-binding domain of nuclear hormone receptor Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in liver.
Sequence
Sequence length 352
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Chemical carcinogenesis - receptor activation   Nuclear Receptor transcription pathway
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Kleefstra syndrome 1 Uncertain significance rs398122411 RCV000074463
NR1I3-related disorder Benign; Likely benign rs2307424, rs34161743, rs188975149, rs544741783, rs146059027 RCV003977468
RCV003920060
RCV003916816
RCV003944322
RCV003964748
Show/Hide Text Mining Associations (119)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acrospiroma Associate 40558528
Autoimmune Diseases Associate 39530971
Blood Coagulation Disorders Stimulate 37295816
Brain Diseases Associate 35443752
Brain Neoplasms Associate 36805678, 37992682
Breast Neoplasms Associate 28885562, 37480115
Burkitt Lymphoma Inhibit 33631963, 37006273
Carcinoma Associate 35499393
Carcinoma Hepatocellular Associate 21557330, 22447115, 27311637, 31880390, 36640111
Carcinoma Non Small Cell Lung Associate 35443752