NR1I3 (nuclear receptor subfamily 1 group I member 3)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9970
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear receptor subfamily 1 group I member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NR1I3
Synonyms (NCBI Gene) Gene synonyms aliases
CAR, CAR1, MB67
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target g
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
RARA Activation 20211151
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 11114890
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding TAS 9783588
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603881 7969 ENSG00000143257
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q14994
Protein name Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Protein function Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene
PDB 1XV9 , 1XVP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00105 zf-C4 9 → 78 Zinc finger, C4 type (two domains) Domain
PF00104 Hormone_recep 157 → 338 Ligand-binding domain of nuclear hormone receptor Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in liver.
Sequence
Sequence length 352
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Chemical carcinogenesis - receptor activation   Nuclear Receptor transcription pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 20869355
Metabolic syndrome Metabolic Syndrome X rs367643250, rs587777380, rs777736953 20869355
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)		 20869355
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Mental retardation intellectual disability GenCC
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Show/Hide Text Mining Associations (119)
Associations from Text Mining
Disease Name Relationship Type References
Acrospiroma Associate 40558528
Autoimmune Diseases Associate 39530971
Blood Coagulation Disorders Stimulate 37295816
Brain Diseases Associate 35443752
Brain Neoplasms Associate 36805678, 37992682
Breast Neoplasms Associate 28885562, 37480115
Burkitt Lymphoma Inhibit 33631963, 37006273
Carcinoma Associate 35499393
Carcinoma Hepatocellular Associate 21557330, 22447115, 27311637, 31880390, 36640111
Carcinoma Non Small Cell Lung Associate 35443752