HS3ST4 (heparan sulfate-glucosamine 3-sulfotransferase 4)

Gene

• Entrez ID: 9951
• Gene name: Heparan sulfate-glucosamine 3-sulfotransferase 4
• Gene symbol: HS3ST4
• Synonyms (NCBI Gene): 3-OST-4, 30ST4, 3OST4, h3-OST-4
• Chromosome: 16
• Chromosome location: 16p12.1
• Summary: This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1054958	hsa-miR-1293	CLIP-seq
MIRT1054959	hsa-miR-147	CLIP-seq
MIRT1054960	hsa-miR-298	CLIP-seq
MIRT1054961	hsa-miR-302a	CLIP-seq
MIRT1054962	hsa-miR-302b	CLIP-seq
MIRT1054963	hsa-miR-302c	CLIP-seq
MIRT1054964	hsa-miR-302d	CLIP-seq
MIRT1054965	hsa-miR-302e	CLIP-seq
MIRT1054966	hsa-miR-3152-5p	CLIP-seq
MIRT1054967	hsa-miR-3650	CLIP-seq
MIRT1054968	hsa-miR-372	CLIP-seq
MIRT1054969	hsa-miR-373	CLIP-seq
MIRT1054970	hsa-miR-3911	CLIP-seq
MIRT1054971	hsa-miR-4455	CLIP-seq
MIRT1054972	hsa-miR-4483	CLIP-seq
MIRT1054973	hsa-miR-4677-3p	CLIP-seq
MIRT1054974	hsa-miR-4679	CLIP-seq
MIRT1054975	hsa-miR-4774-3p	CLIP-seq
MIRT1054976	hsa-miR-520a-3p	CLIP-seq
MIRT1054977	hsa-miR-520b	CLIP-seq
MIRT1054978	hsa-miR-520c-3p	CLIP-seq
MIRT1054979	hsa-miR-520d-3p	CLIP-seq
MIRT1054980	hsa-miR-520e	CLIP-seq
MIRT1054981	hsa-miR-520f	CLIP-seq
MIRT1054982	hsa-miR-609	CLIP-seq
MIRT1054983	hsa-miR-644	CLIP-seq
MIRT2012495	hsa-miR-1289	CLIP-seq
MIRT2012496	hsa-miR-3157-5p	CLIP-seq
MIRT2012497	hsa-miR-3690	CLIP-seq
MIRT2012498	hsa-miR-4254	CLIP-seq
MIRT2012499	hsa-miR-4691-3p	CLIP-seq
MIRT2012500	hsa-miR-512-5p	CLIP-seq
MIRT2012495	hsa-miR-1289	CLIP-seq
MIRT2437641	hsa-miR-3160-5p	CLIP-seq
MIRT2437642	hsa-miR-3198	CLIP-seq
MIRT2437643	hsa-miR-4294	CLIP-seq
MIRT2437644	hsa-miR-4309	CLIP-seq
MIRT2012495	hsa-miR-1289	CLIP-seq
MIRT2437641	hsa-miR-3160-5p	CLIP-seq
MIRT2437642	hsa-miR-3198	CLIP-seq
MIRT2437643	hsa-miR-4294	CLIP-seq
MIRT2437644	hsa-miR-4309	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IBA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	NAS	9988767
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030201	Process	Heparan sulfate proteoglycan metabolic process	NAS	9988767

Other IDs

• MIM: 604059
• HGNC: 5200
• e!Ensembl: ENSG00000182601

Protein

• UniProt ID: Q9Y661
• Protein name: Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (3-OST-4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4)
• Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-an
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	197 → 446	Sulfotransferase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:9988767}.
• Sequence:

  MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ
  FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA
  PGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS
  SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG
  LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ
  TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL
  IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI
  DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK

• Sequence length: 456

Pathways

Reactome:

HS-GAG biosynthesis