Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9908
Gene name Gene Name - the full gene name approved by the HGNC.
G3BP stress granule assembly factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
G3BP2
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000772 hsa-miR-200a-3p Microarray, Northern blot 16331254
MIRT020092 hsa-miR-361-5p Sequencing 20371350
MIRT022458 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023607 hsa-miR-1-3p Proteomics 18668040
MIRT025342 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 19615732, 23279204, 25416956, 25893917, 29892012, 31515488
GO:0005737 Component Cytoplasm NAS 10969074
GO:0005829 Component Cytosol IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
620020 30291 ENSG00000138757
Protein
UniProt ID Q9UN86
Protein name Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Protein function Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granul
PDB 5DRV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02136 NTF2 11 133 Nuclear transport factor 2 (NTF2) domain Domain
PF00076 RRM_1 333 398 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Sequence
MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQND
IHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSV
PNKFYVHNDMFRY
EDEVFGDSEPELDEESEDEVEEEQEERQPSPEPVQENANSGYYEAHP
VTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKNLEELEEKSTTPPPAEPVSLPQEP
PKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVEAKPEVQSQPPRVREQRPRERP
GFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVEL
RINTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRG
EVRLNVEEKKTRAARERETRGG
GDDRRDIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMAQKLGSGRGTGQMEGRFTGQ
RR
Sequence length 482
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 35761386, 37461019
Carcinogenesis Associate 36878903
Esophageal Squamous Cell Carcinoma Associate 33476486
Lymphoma Large B Cell Diffuse Associate 33087075
Melanoma Associate 21343389
Neoplasms Associate 36878903
Osteosarcoma Associate 35761386
Prostatic Neoplasms Associate 29378906, 35761386
Squamous Cell Carcinoma of Head and Neck Associate 36878903