Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9902
Gene name Gene Name - the full gene name approved by the HGNC.	Mannose receptor C-type 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MRC2
Synonyms (NCBI Gene) Gene synonyms aliases	CD280, CLEC13E, ENDO180, UPARAP
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q23.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization a

Show/Hide all(123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001355	hsa-miR-1-3p	pSILAC	18668040
MIRT001355	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT051126	hsa-miR-16-5p	CLASH	23622248
MIRT047526	hsa-miR-10a-5p	CLASH	23622248
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT1157633	hsa-miR-3170	CLIP-seq
MIRT1157634	hsa-miR-342-5p	CLIP-seq
MIRT1157635	hsa-miR-3690	CLIP-seq
MIRT1157636	hsa-miR-4254	CLIP-seq
MIRT1157637	hsa-miR-4268	CLIP-seq
MIRT1157638	hsa-miR-4448	CLIP-seq
MIRT1157639	hsa-miR-4651	CLIP-seq
MIRT1157640	hsa-miR-4664-5p	CLIP-seq
MIRT1157641	hsa-miR-593	CLIP-seq
MIRT1157642	hsa-miR-608	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT1551383	hsa-miR-4755-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2045098	hsa-miR-548ac	CLIP-seq
MIRT2045099	hsa-miR-548ae	CLIP-seq
MIRT2045100	hsa-miR-548aj	CLIP-seq
MIRT2045101	hsa-miR-548am	CLIP-seq
MIRT2045102	hsa-miR-548d-3p	CLIP-seq
MIRT2045103	hsa-miR-548x	CLIP-seq
MIRT2045104	hsa-miR-548z	CLIP-seq
MIRT2438781	hsa-miR-2392	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2465650	hsa-miR-2467-5p	CLIP-seq
MIRT2465651	hsa-miR-3194-3p	CLIP-seq
MIRT2465652	hsa-miR-3944-3p	CLIP-seq
MIRT1157637	hsa-miR-4268	CLIP-seq
MIRT2465653	hsa-miR-760	CLIP-seq
MIRT2573109	hsa-miR-1207-3p	CLIP-seq
MIRT2573110	hsa-miR-1224-3p	CLIP-seq
MIRT2573111	hsa-miR-1260	CLIP-seq
MIRT2573112	hsa-miR-1260b	CLIP-seq
MIRT2573113	hsa-miR-1280	CLIP-seq
MIRT2573114	hsa-miR-1538	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT2573115	hsa-miR-193a-5p	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT2573116	hsa-miR-24	CLIP-seq
MIRT2573117	hsa-miR-3620	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT2573118	hsa-miR-3940-3p	CLIP-seq
MIRT2573119	hsa-miR-4267	CLIP-seq
MIRT2573120	hsa-miR-4292	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2573121	hsa-miR-4690-3p	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2573122	hsa-miR-4725-5p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2573123	hsa-miR-4745-3p	CLIP-seq
MIRT2573124	hsa-miR-4793-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2573125	hsa-miR-504	CLIP-seq
MIRT2573126	hsa-miR-512-5p	CLIP-seq
MIRT2573127	hsa-miR-532-3p	CLIP-seq
MIRT2573128	hsa-miR-548c-3p	CLIP-seq
MIRT2573129	hsa-miR-662	CLIP-seq
MIRT2573130	hsa-miR-873	CLIP-seq
MIRT2573109	hsa-miR-1207-3p	CLIP-seq
MIRT2573110	hsa-miR-1224-3p	CLIP-seq
MIRT2573111	hsa-miR-1260	CLIP-seq
MIRT2573112	hsa-miR-1260b	CLIP-seq
MIRT2573113	hsa-miR-1280	CLIP-seq
MIRT2573114	hsa-miR-1538	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT2573115	hsa-miR-193a-5p	CLIP-seq
MIRT2685295	hsa-miR-214	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT2438781	hsa-miR-2392	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT2685296	hsa-miR-3619-5p	CLIP-seq
MIRT2573117	hsa-miR-3620	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT2573118	hsa-miR-3940-3p	CLIP-seq
MIRT2573119	hsa-miR-4267	CLIP-seq
MIRT2685297	hsa-miR-4269	CLIP-seq
MIRT2573120	hsa-miR-4292	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT2685298	hsa-miR-4530	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2573121	hsa-miR-4690-3p	CLIP-seq
MIRT2685299	hsa-miR-4690-5p	CLIP-seq
MIRT2685300	hsa-miR-4691-3p	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2573122	hsa-miR-4725-5p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2573123	hsa-miR-4745-3p	CLIP-seq
MIRT2685301	hsa-miR-4758-3p	CLIP-seq
MIRT2573124	hsa-miR-4793-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2573125	hsa-miR-504	CLIP-seq
MIRT2573126	hsa-miR-512-5p	CLIP-seq
MIRT2573127	hsa-miR-532-3p	CLIP-seq
MIRT2573128	hsa-miR-548c-3p	CLIP-seq
MIRT2573129	hsa-miR-662	CLIP-seq
MIRT2685302	hsa-miR-761	CLIP-seq
MIRT2573130	hsa-miR-873	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0005515	Function	Protein binding	IPI	7904248, 26481812
GO:0005518	Function	Collagen binding	IDA	10636902, 12972549
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006897	Process	Endocytosis	IEA
GO:0016020	Component	Membrane	HDA	16210410
GO:0016021	Component	Integral component of membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030574	Process	Collagen catabolic process	IDA	12972549
GO:0038023	Function	Signaling receptor activity	IBA	21873635

MIM	HGNC	e!Ensembl
612264	16875	ENSG00000011028

Protein

UniProt ID

Q9UBG0

Protein name

C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protei

Protein function

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involve

PDB

5AO5 , 5AO6 , 5E4K , 5E4L , 5EW6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00040	fn2	187 → 228	Fibronectin type II domain	Domain
PF00059	Lectin_C	255 → 361	Lectin C-type domain	Domain
PF00059	Lectin_C	399 → 506	Lectin C-type domain	Domain
PF00059	Lectin_C	538 → 646	Lectin C-type domain	Domain
PF00059	Lectin_C	693 → 810	Lectin C-type domain	Domain
PF00059	Lectin_C	842 → 952	Lectin C-type domain	Domain
PF00059	Lectin_C	993 → 1109	Lectin C-type domain	Domain
PF00059	Lectin_C	1142 → 1245	Lectin C-type domain	Domain
PF00059	Lectin_C	1285 → 1395	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150,

Sequence

MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGG
QVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLR
WHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQG
NSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWD
KDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGL
NDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCK
KKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSI
HSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLED
CVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQV
TYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDE
VMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPD
PTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEE
HFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDD
DIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFF
EHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRF
RWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQ
PPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQ
AFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAV
VLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLL
QKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVS
EEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGS
CPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQS
YEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWR
PGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQ
SIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE

Sequence length

1479

Interactions

View interactions

	KEGG		Reactome
	Phagosome Tuberculosis		Cross-presentation of soluble exogenous antigens (endosomes)

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diabetes	Diabetes			GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Aortic Root Aneurysm	Inhibit	33230159
Calcinosis Cutis	Associate	26567111
Carcinoma Renal Cell	Stimulate	34768883
Glioblastoma	Associate	20339555, 28365151
Glioma	Associate	20339555
Marfan Syndrome	Inhibit	33230159
Mesothelioma Malignant	Stimulate	34768883
Neoplasms	Associate	20339555, 25162823, 26567111, 37340445
Osteosarcoma	Associate	35312779
Ovarian Neoplasms	Associate	34336102, 39972314
Pancreatic Neoplasms	Associate	22792318
Prostate Cancer Hereditary 7	Associate	36613987
Prostatic Neoplasms	Associate	25381222, 26567111, 36613987

MRC2 (mannose receptor C-type 2)