Gene Gene information from NCBI Gene database.
Entrez ID 9899
Gene name Synaptic vesicle glycoprotein 2B
Gene symbol SV2B
Synonyms (NCBI Gene)
HsT19680SLC22B2
Chromosome 15
Chromosome location 15q26.1
Summary This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle traffic
miRNA miRNA information provided by mirtarbase database.
537
miRTarBase ID miRNA Experiments Reference
MIRT030144 hsa-miR-26b-5p Microarray 19088304
MIRT713239 hsa-miR-211-3p HITS-CLIP 19536157
MIRT713238 hsa-miR-4270 HITS-CLIP 19536157
MIRT713237 hsa-miR-4441 HITS-CLIP 19536157
MIRT713236 hsa-miR-6754-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0005515 Function Protein binding IPI 25416956
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0006836 Process Neurotransmitter transport IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
185861 16874 ENSG00000185518
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7L1I2
Protein name Synaptic vesicle glycoprotein 2B
Protein function Probably plays a role in the control of regulated secretion in neural and endocrine cells. ; (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhance
PDB 8UO8 , 9F1R , 9F2B , 9F2J , 9F2Y , 9F3C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00083 Sugar_tr 97 416 Sugar (and other) transporter Family
PF07690 MFS_1 519 681 Major Facilitator Superfamily Family
Sequence
Sequence length 683
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  ECM-receptor interaction   Toxicity of botulinum toxin type D (BoNT/D)
Toxicity of botulinum toxin type A (BoNT/A)
Toxicity of botulinum toxin type F (BoNT/F)
Toxicity of botulinum toxin type E (BoNT/E)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193920952 RCV000149081
SV2B-related disorder Likely benign rs146788122 RCV003923822
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 27641902
Adenoma Associate 31200767
Alzheimer Disease Inhibit 27641902
Alzheimer Disease Associate 33588752
Brain Neoplasms Associate 40596133
Colorectal Neoplasms Associate 31200767
Epilepsy Associate 33588752
Glioblastoma Associate 32667033, 40596133
Heredodegenerative Disorders Nervous System Associate 33588752
Medulloblastoma Stimulate 40596133