Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9899
Gene name Gene Name - the full gene name approved by the HGNC.
Synaptic vesicle glycoprotein 2B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SV2B
Synonyms (NCBI Gene) Gene synonyms aliases
HsT19680, SLC22B2
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q26.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle traffic
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030144 hsa-miR-26b-5p Microarray 19088304
MIRT713239 hsa-miR-211-3p HITS-CLIP 19536157
MIRT713238 hsa-miR-4270 HITS-CLIP 19536157
MIRT713237 hsa-miR-4441 HITS-CLIP 19536157
MIRT713236 hsa-miR-6754-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0005515 Function Protein binding IPI 25416956
GO:0005886 Component Plasma membrane TAS
GO:0006836 Process Neurotransmitter transport IEA
GO:0007268 Process Chemical synaptic transmission IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
185861 16874 ENSG00000185518
Protein
UniProt ID Q7L1I2
Protein name Synaptic vesicle glycoprotein 2B
Protein function Probably plays a role in the control of regulated secretion in neural and endocrine cells. ; (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhance
PDB 8UO8 , 9F1R , 9F2B , 9F2J , 9F2Y , 9F3C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00083 Sugar_tr 97 416 Sugar (and other) transporter Family
PF07690 MFS_1 519 681 Major Facilitator Superfamily Family
Sequence
Sequence length 683
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  ECM-receptor interaction   Toxicity of botulinum toxin type D (BoNT/D)
Toxicity of botulinum toxin type A (BoNT/A)
Toxicity of botulinum toxin type F (BoNT/F)
Toxicity of botulinum toxin type E (BoNT/E)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Kidney disease Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 16943307
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 27641902
Adenoma Associate 31200767
Alzheimer Disease Inhibit 27641902
Alzheimer Disease Associate 33588752
Brain Neoplasms Associate 40596133
Colorectal Neoplasms Associate 31200767
Epilepsy Associate 33588752
Glioblastoma Associate 32667033, 40596133
Heredodegenerative Disorders Nervous System Associate 33588752
Medulloblastoma Stimulate 40596133