Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	9886
Gene name	Rho related BTB domain containing 1
Gene symbol	RHOBTB1
Synonyms (NCBI Gene)	-
Chromosome	10
Chromosome location	10q21.2
Summary	The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The p

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018495	hsa-miR-335-5p	Microarray	18185580
MIRT050128	hsa-miR-26a-5p	CLASH	23622248
MIRT437512	hsa-miR-31-5p	Luciferase reporter assay	23258531
MIRT437512	hsa-miR-31-5p	Luciferase reporter assay	23258531
MIRT1305401	hsa-miR-1244	CLIP-seq
MIRT1305402	hsa-miR-1271	CLIP-seq
MIRT1305403	hsa-miR-1297	CLIP-seq
MIRT1305404	hsa-miR-182	CLIP-seq
MIRT1305405	hsa-miR-1910	CLIP-seq
MIRT1305406	hsa-miR-26a	CLIP-seq
MIRT1305407	hsa-miR-26b	CLIP-seq
MIRT1305408	hsa-miR-31	CLIP-seq
MIRT1305409	hsa-miR-3122	CLIP-seq
MIRT1305410	hsa-miR-3165	CLIP-seq
MIRT1305411	hsa-miR-3185	CLIP-seq
MIRT1305412	hsa-miR-3689a-3p	CLIP-seq
MIRT1305413	hsa-miR-3689c	CLIP-seq
MIRT1305414	hsa-miR-383	CLIP-seq
MIRT1305415	hsa-miR-3913-5p	CLIP-seq
MIRT1305416	hsa-miR-4276	CLIP-seq
MIRT1305417	hsa-miR-4325	CLIP-seq
MIRT1305418	hsa-miR-4465	CLIP-seq
MIRT1305419	hsa-miR-4473	CLIP-seq
MIRT1305420	hsa-miR-4528	CLIP-seq
MIRT1305421	hsa-miR-455-3p	CLIP-seq
MIRT1305422	hsa-miR-4652-3p	CLIP-seq
MIRT1305423	hsa-miR-4697-3p	CLIP-seq
MIRT1305424	hsa-miR-4729	CLIP-seq
MIRT1305425	hsa-miR-4789-5p	CLIP-seq
MIRT1305426	hsa-miR-4796-3p	CLIP-seq
MIRT1305427	hsa-miR-507	CLIP-seq
MIRT1305428	hsa-miR-509-3p	CLIP-seq
MIRT1305429	hsa-miR-512-3p	CLIP-seq
MIRT1305430	hsa-miR-520f	CLIP-seq
MIRT1305431	hsa-miR-548t	CLIP-seq
MIRT1305432	hsa-miR-557	CLIP-seq
MIRT1305433	hsa-miR-579	CLIP-seq
MIRT1305434	hsa-miR-590-3p	CLIP-seq
MIRT1305435	hsa-miR-885-5p	CLIP-seq
MIRT1305436	hsa-miR-96	CLIP-seq
MIRT1305410	hsa-miR-3165	CLIP-seq
MIRT1305414	hsa-miR-383	CLIP-seq
MIRT1305426	hsa-miR-4796-3p	CLIP-seq
MIRT1305430	hsa-miR-520f	CLIP-seq
MIRT1305431	hsa-miR-548t	CLIP-seq
MIRT2090367	hsa-miR-204	CLIP-seq
MIRT2090368	hsa-miR-211	CLIP-seq
MIRT2090369	hsa-miR-4419a	CLIP-seq
MIRT2090370	hsa-miR-4510	CLIP-seq
MIRT2090371	hsa-miR-4693-3p	CLIP-seq
MIRT2315228	hsa-miR-1226	CLIP-seq
MIRT2315229	hsa-miR-1261	CLIP-seq
MIRT2315230	hsa-miR-146b-3p	CLIP-seq
MIRT2315231	hsa-miR-155	CLIP-seq
MIRT2315232	hsa-miR-299-3p	CLIP-seq
MIRT2315233	hsa-miR-3123	CLIP-seq
MIRT2315234	hsa-miR-3157-3p	CLIP-seq
MIRT2315235	hsa-miR-3173-5p	CLIP-seq
MIRT2315236	hsa-miR-3174	CLIP-seq
MIRT2315237	hsa-miR-3646	CLIP-seq
MIRT2315238	hsa-miR-3682-5p	CLIP-seq
MIRT2315239	hsa-miR-4265	CLIP-seq
MIRT2315240	hsa-miR-4296	CLIP-seq
MIRT2315241	hsa-miR-4308	CLIP-seq
MIRT2315242	hsa-miR-4310	CLIP-seq
MIRT2315243	hsa-miR-4311	CLIP-seq
MIRT2315244	hsa-miR-4322	CLIP-seq
MIRT2315245	hsa-miR-4417	CLIP-seq
MIRT2315246	hsa-miR-4484	CLIP-seq
MIRT2315247	hsa-miR-4704-5p	CLIP-seq
MIRT2315248	hsa-miR-4731-5p	CLIP-seq
MIRT2315249	hsa-miR-4738-5p	CLIP-seq
MIRT2315250	hsa-miR-4753-5p	CLIP-seq
MIRT2315251	hsa-miR-513a-5p	CLIP-seq
MIRT2315252	hsa-miR-548an	CLIP-seq
MIRT2315253	hsa-miR-570	CLIP-seq
MIRT2315254	hsa-miR-630	CLIP-seq
MIRT2315255	hsa-miR-874	CLIP-seq
MIRT2315251	hsa-miR-513a-5p	CLIP-seq
MIRT2432723	hsa-miR-141	CLIP-seq
MIRT2432724	hsa-miR-200a	CLIP-seq
MIRT2432725	hsa-miR-384	CLIP-seq
MIRT2315253	hsa-miR-570	CLIP-seq
MIRT2611526	hsa-miR-1207-5p	CLIP-seq
MIRT2611527	hsa-miR-203	CLIP-seq
MIRT2611528	hsa-miR-297	CLIP-seq
MIRT2611529	hsa-miR-3064-3p	CLIP-seq
MIRT2611530	hsa-miR-3143	CLIP-seq
MIRT2611531	hsa-miR-331-3p	CLIP-seq
MIRT2611532	hsa-miR-3665	CLIP-seq
MIRT2611533	hsa-miR-370	CLIP-seq
MIRT2432725	hsa-miR-384	CLIP-seq
MIRT2611534	hsa-miR-3911	CLIP-seq
MIRT2611535	hsa-miR-3934	CLIP-seq
MIRT2611536	hsa-miR-4633-3p	CLIP-seq
MIRT2611537	hsa-miR-4736	CLIP-seq
MIRT2611538	hsa-miR-4763-3p	CLIP-seq
MIRT2611539	hsa-miR-567	CLIP-seq
MIRT2611540	hsa-miR-626	CLIP-seq
MIRT2611541	hsa-miR-663b	CLIP-seq
MIRT2689748	hsa-miR-548c-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005856	Component	Cytoskeleton	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0007015	Process	Actin filament organization	IBA
GO:0007163	Process	Establishment or maintenance of cell polarity	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0008360	Process	Regulation of cell shape	IBA
GO:0010008	Component	Endosome membrane	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0019901	Function	Protein kinase binding	IBA
GO:0030865	Process	Cortical cytoskeleton organization	IBA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA
GO:0042995	Component	Cell projection	IBA

MIM	HGNC	e!Ensembl
607351	18738	ENSG00000072422

O94844

Protein name

Rho-related BTB domain-containing protein 1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	16 → 209	Ras family	Domain
PF00651	BTB	384 → 457	BTB/POZ domain	Domain
PF00651	BTB	475 → 583	BTB/POZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues. {ECO:0000269|PubMed:12426103}.

Sequence

MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYR
VCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKS
MWYPEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKE
LGLPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPP
PVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFAHRIYLATSSSKFYDLFLMEC
EESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSNKSLVEALGLE
AEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYT
GQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLS
KGTFSDVTFKLDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVL
DYLYTKQLSPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSY
LELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEE
DHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA

Sequence length

696

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		Rho GTPase cycle

RHOBTB1 (Rho related BTB domain containing 1)