TLK1 (tousled like kinase 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9874 |
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Tousled like kinase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TLK1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
PKU-beta |
Chromosome
Chromosome number
|
2 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2q31.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal ac |
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
Protein | |||||||||||
UniProt ID | Q9UKI8 | ||||||||||
Protein name | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | ||||||||||
Protein function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. | ||||||||||
Family and domains |
Pfam
|
||||||||||
Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:10588641, ECO:00 | ||||||||||
Sequence |
|
||||||||||
Sequence length | 766 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|