TRIM14 (tripartite motif containing 14)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9830 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Tripartite motif containing 14 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TRIM14 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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Chromosome
Chromosome number
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9 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q22.33 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and it |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||||||||||||
UniProt ID | Q14142 | ||||||||||||||||||||
Protein name | Tripartite motif-containing protein 14 | ||||||||||||||||||||
Protein function | Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of v | ||||||||||||||||||||
PDB | 6JBM | ||||||||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Highest expression in liver; undetectable in skeletal muscle. | ||||||||||||||||||||
Sequence |
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Sequence length | 442 | ||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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