Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9830
Gene name Gene Name - the full gene name approved by the HGNC.	Tripartite motif containing 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRIM14
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q22.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and it

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025840	hsa-miR-7-5p	Microarray	19073608
MIRT044852	hsa-miR-320a	CLASH	23622248
MIRT646923	hsa-miR-21-3p	HITS-CLIP	23824327
MIRT646922	hsa-miR-3591-3p	HITS-CLIP	23824327
MIRT646921	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT646920	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT646919	hsa-miR-4261	HITS-CLIP	23824327
MIRT646918	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT646917	hsa-miR-3153	HITS-CLIP	23824327
MIRT646916	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT646915	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT646914	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT646913	hsa-miR-4425	HITS-CLIP	23824327
MIRT646912	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT646911	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT736994	hsa-miR-325	Luciferase reporter assay, Western blotting, qRT-PCR	34054957
MIRT646923	hsa-miR-21-3p	HITS-CLIP	23824327
MIRT646922	hsa-miR-3591-3p	HITS-CLIP	23824327
MIRT646921	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT646920	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT646919	hsa-miR-4261	HITS-CLIP	23824327
MIRT646918	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT646917	hsa-miR-3153	HITS-CLIP	23824327
MIRT646916	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT646915	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT646914	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT646913	hsa-miR-4425	HITS-CLIP	23824327
MIRT646912	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT646911	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT1453007	hsa-miR-1183	CLIP-seq
MIRT1453008	hsa-miR-1207-5p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT1453010	hsa-miR-1224-5p	CLIP-seq
MIRT1453011	hsa-miR-124	CLIP-seq
MIRT1453012	hsa-miR-1243	CLIP-seq
MIRT1453013	hsa-miR-1245b-3p	CLIP-seq
MIRT1453014	hsa-miR-1252	CLIP-seq
MIRT1453015	hsa-miR-1253	CLIP-seq
MIRT1453016	hsa-miR-1254	CLIP-seq
MIRT1453017	hsa-miR-1262	CLIP-seq
MIRT1453018	hsa-miR-1297	CLIP-seq
MIRT1453019	hsa-miR-1299	CLIP-seq
MIRT1453020	hsa-miR-1301	CLIP-seq
MIRT1453021	hsa-miR-142-3p	CLIP-seq
MIRT1453022	hsa-miR-148a	CLIP-seq
MIRT1453023	hsa-miR-148b	CLIP-seq
MIRT1453024	hsa-miR-152	CLIP-seq
MIRT1453025	hsa-miR-15a	CLIP-seq
MIRT1453026	hsa-miR-15b	CLIP-seq
MIRT1453027	hsa-miR-16	CLIP-seq
MIRT1453028	hsa-miR-190	CLIP-seq
MIRT1453029	hsa-miR-190b	CLIP-seq
MIRT1453030	hsa-miR-195	CLIP-seq
MIRT1453031	hsa-miR-216a	CLIP-seq
MIRT1453032	hsa-miR-2355-5p	CLIP-seq
MIRT1453033	hsa-miR-2682	CLIP-seq
MIRT1453034	hsa-miR-26a	CLIP-seq
MIRT1453035	hsa-miR-26b	CLIP-seq
MIRT1453036	hsa-miR-2861	CLIP-seq
MIRT1453037	hsa-miR-2909	CLIP-seq
MIRT1453038	hsa-miR-3116	CLIP-seq
MIRT1453039	hsa-miR-3117-3p	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT1453041	hsa-miR-3138	CLIP-seq
MIRT1453042	hsa-miR-3149	CLIP-seq
MIRT1453043	hsa-miR-3169	CLIP-seq
MIRT1453044	hsa-miR-3182	CLIP-seq
MIRT1453045	hsa-miR-3185	CLIP-seq
MIRT1453046	hsa-miR-3186-5p	CLIP-seq
MIRT1453047	hsa-miR-3190	CLIP-seq
MIRT1453048	hsa-miR-3192	CLIP-seq
MIRT1453049	hsa-miR-320b	CLIP-seq
MIRT1453050	hsa-miR-320c	CLIP-seq
MIRT1453051	hsa-miR-320d	CLIP-seq
MIRT1453052	hsa-miR-320e	CLIP-seq
MIRT1453053	hsa-miR-330-3p	CLIP-seq
MIRT1453054	hsa-miR-335	CLIP-seq
MIRT1453055	hsa-miR-340	CLIP-seq
MIRT1453056	hsa-miR-342-5p	CLIP-seq
MIRT1453057	hsa-miR-3529	CLIP-seq
MIRT1453058	hsa-miR-3616-3p	CLIP-seq
MIRT1453059	hsa-miR-3622a-3p	CLIP-seq
MIRT1453060	hsa-miR-3622b-3p	CLIP-seq
MIRT1453061	hsa-miR-3649	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT1453063	hsa-miR-3653	CLIP-seq
MIRT1453064	hsa-miR-370	CLIP-seq
MIRT1453065	hsa-miR-3714	CLIP-seq
MIRT1453066	hsa-miR-377	CLIP-seq
MIRT1453067	hsa-miR-379	CLIP-seq
MIRT1453068	hsa-miR-3910	CLIP-seq
MIRT1453069	hsa-miR-3927	CLIP-seq
MIRT1453070	hsa-miR-424	CLIP-seq
MIRT1453071	hsa-miR-4270	CLIP-seq
MIRT1453072	hsa-miR-4300	CLIP-seq
MIRT1453073	hsa-miR-4311	CLIP-seq
MIRT1453074	hsa-miR-4327	CLIP-seq
MIRT1453075	hsa-miR-4419a	CLIP-seq
MIRT1453076	hsa-miR-4422	CLIP-seq
MIRT1453077	hsa-miR-4429	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT1453079	hsa-miR-4436b-3p	CLIP-seq
MIRT1453080	hsa-miR-4438	CLIP-seq
MIRT1453081	hsa-miR-4441	CLIP-seq
MIRT1453082	hsa-miR-4446-3p	CLIP-seq
MIRT1453083	hsa-miR-4465	CLIP-seq
MIRT1453084	hsa-miR-4466	CLIP-seq
MIRT1453085	hsa-miR-4475	CLIP-seq
MIRT1453086	hsa-miR-4476	CLIP-seq
MIRT1453087	hsa-miR-4477b	CLIP-seq
MIRT1453088	hsa-miR-4491	CLIP-seq
MIRT1453089	hsa-miR-4492	CLIP-seq
MIRT1453090	hsa-miR-4498	CLIP-seq
MIRT1453091	hsa-miR-449c	CLIP-seq
MIRT1453092	hsa-miR-4502	CLIP-seq
MIRT1453093	hsa-miR-4505	CLIP-seq
MIRT1453094	hsa-miR-4510	CLIP-seq
MIRT1453095	hsa-miR-4515	CLIP-seq
MIRT1453096	hsa-miR-4528	CLIP-seq
MIRT1453097	hsa-miR-455-3p	CLIP-seq
MIRT1453098	hsa-miR-4639-3p	CLIP-seq
MIRT1453099	hsa-miR-4639-5p	CLIP-seq
MIRT1453100	hsa-miR-4640-5p	CLIP-seq
MIRT1453101	hsa-miR-4651	CLIP-seq
MIRT1453102	hsa-miR-4652-3p	CLIP-seq
MIRT1453103	hsa-miR-4657	CLIP-seq
MIRT1453104	hsa-miR-4660	CLIP-seq
MIRT1453105	hsa-miR-4664-5p	CLIP-seq
MIRT1453106	hsa-miR-4679	CLIP-seq
MIRT1453107	hsa-miR-4699-5p	CLIP-seq
MIRT1453108	hsa-miR-4701-3p	CLIP-seq
MIRT1453109	hsa-miR-4707-3p	CLIP-seq
MIRT1453110	hsa-miR-4710	CLIP-seq
MIRT1453111	hsa-miR-4712-3p	CLIP-seq
MIRT1453112	hsa-miR-4726-5p	CLIP-seq
MIRT1453113	hsa-miR-4731-5p	CLIP-seq
MIRT1453114	hsa-miR-4735-5p	CLIP-seq
MIRT1453115	hsa-miR-4751	CLIP-seq
MIRT1453116	hsa-miR-4759	CLIP-seq
MIRT1453117	hsa-miR-4763-3p	CLIP-seq
MIRT1453118	hsa-miR-4766-3p	CLIP-seq
MIRT1453119	hsa-miR-4766-5p	CLIP-seq
MIRT1453120	hsa-miR-4771	CLIP-seq
MIRT1453121	hsa-miR-4775	CLIP-seq
MIRT1453122	hsa-miR-4782-5p	CLIP-seq
MIRT1453123	hsa-miR-4800-5p	CLIP-seq
MIRT1453124	hsa-miR-486-3p	CLIP-seq
MIRT1453125	hsa-miR-497	CLIP-seq
MIRT1453126	hsa-miR-499a-5p	CLIP-seq
MIRT1453127	hsa-miR-501-3p	CLIP-seq
MIRT1453128	hsa-miR-502-3p	CLIP-seq
MIRT1453129	hsa-miR-5047	CLIP-seq
MIRT1453130	hsa-miR-506	CLIP-seq
MIRT1453131	hsa-miR-509-3p	CLIP-seq
MIRT1453132	hsa-miR-5095	CLIP-seq
MIRT1453133	hsa-miR-510	CLIP-seq
MIRT1453134	hsa-miR-512-5p	CLIP-seq
MIRT1453135	hsa-miR-516b	CLIP-seq
MIRT1453136	hsa-miR-541	CLIP-seq
MIRT1453137	hsa-miR-542-5p	CLIP-seq
MIRT1453138	hsa-miR-548a-5p	CLIP-seq
MIRT1453139	hsa-miR-548ab	CLIP-seq
MIRT1453140	hsa-miR-548ag	CLIP-seq
MIRT1453141	hsa-miR-548ai	CLIP-seq
MIRT1453142	hsa-miR-548ak	CLIP-seq
MIRT1453143	hsa-miR-548b-5p	CLIP-seq
MIRT1453144	hsa-miR-548c-5p	CLIP-seq
MIRT1453145	hsa-miR-548d-5p	CLIP-seq
MIRT1453146	hsa-miR-548h	CLIP-seq
MIRT1453147	hsa-miR-548i	CLIP-seq
MIRT1453148	hsa-miR-548j	CLIP-seq
MIRT1453149	hsa-miR-548k	CLIP-seq
MIRT1453150	hsa-miR-548l	CLIP-seq
MIRT1453151	hsa-miR-548m	CLIP-seq
MIRT1453152	hsa-miR-548w	CLIP-seq
MIRT1453153	hsa-miR-548y	CLIP-seq
MIRT1453154	hsa-miR-559	CLIP-seq
MIRT1453155	hsa-miR-568	CLIP-seq
MIRT1453156	hsa-miR-582-5p	CLIP-seq
MIRT1453157	hsa-miR-590-3p	CLIP-seq
MIRT1453158	hsa-miR-608	CLIP-seq
MIRT1453159	hsa-miR-637	CLIP-seq
MIRT1453160	hsa-miR-642b	CLIP-seq
MIRT1453161	hsa-miR-651	CLIP-seq
MIRT1453162	hsa-miR-654-5p	CLIP-seq
MIRT1453163	hsa-miR-658	CLIP-seq
MIRT1453164	hsa-miR-661	CLIP-seq
MIRT1453165	hsa-miR-675	CLIP-seq
MIRT1453166	hsa-miR-7	CLIP-seq
MIRT1453167	hsa-miR-758	CLIP-seq
MIRT1453168	hsa-miR-762	CLIP-seq
MIRT1453169	hsa-miR-767-5p	CLIP-seq
MIRT1453170	hsa-miR-920	CLIP-seq
MIRT1453171	hsa-miR-922	CLIP-seq
MIRT1453172	hsa-miR-1234	CLIP-seq
MIRT1453173	hsa-miR-150	CLIP-seq
MIRT1453172	hsa-miR-1234	CLIP-seq
MIRT1453173	hsa-miR-150	CLIP-seq
MIRT1453013	hsa-miR-1245b-3p	CLIP-seq
MIRT1453015	hsa-miR-1253	CLIP-seq
MIRT1453016	hsa-miR-1254	CLIP-seq
MIRT2135699	hsa-miR-125a-3p	CLIP-seq
MIRT2135700	hsa-miR-1285	CLIP-seq
MIRT2135701	hsa-miR-185	CLIP-seq
MIRT2135702	hsa-miR-18a	CLIP-seq
MIRT2135703	hsa-miR-18b	CLIP-seq
MIRT1453028	hsa-miR-190	CLIP-seq
MIRT1453029	hsa-miR-190b	CLIP-seq
MIRT2135704	hsa-miR-1914	CLIP-seq
MIRT2135705	hsa-miR-1915	CLIP-seq
MIRT1453032	hsa-miR-2355-5p	CLIP-seq
MIRT2135706	hsa-miR-2681	CLIP-seq
MIRT2135707	hsa-miR-28-5p	CLIP-seq
MIRT1453037	hsa-miR-2909	CLIP-seq
MIRT1453038	hsa-miR-3116	CLIP-seq
MIRT2135708	hsa-miR-3139	CLIP-seq
MIRT2135709	hsa-miR-3152-5p	CLIP-seq
MIRT2135710	hsa-miR-3158-3p	CLIP-seq
MIRT1453043	hsa-miR-3169	CLIP-seq
MIRT2135711	hsa-miR-3171	CLIP-seq
MIRT2135712	hsa-miR-3184	CLIP-seq
MIRT2135713	hsa-miR-3187-5p	CLIP-seq
MIRT2135714	hsa-miR-326	CLIP-seq
MIRT2135715	hsa-miR-330-5p	CLIP-seq
MIRT2135716	hsa-miR-345	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT1453063	hsa-miR-3653	CLIP-seq
MIRT2135717	hsa-miR-3689d	CLIP-seq
MIRT1453064	hsa-miR-370	CLIP-seq
MIRT1453065	hsa-miR-3714	CLIP-seq
MIRT1453066	hsa-miR-377	CLIP-seq
MIRT2135718	hsa-miR-378g	CLIP-seq
MIRT2135719	hsa-miR-383	CLIP-seq
MIRT2135720	hsa-miR-3911	CLIP-seq
MIRT2135721	hsa-miR-3978	CLIP-seq
MIRT2135722	hsa-miR-423-5p	CLIP-seq
MIRT2135723	hsa-miR-4251	CLIP-seq
MIRT2135724	hsa-miR-4256	CLIP-seq
MIRT2135725	hsa-miR-4305	CLIP-seq
MIRT2135726	hsa-miR-4306	CLIP-seq
MIRT1453074	hsa-miR-4327	CLIP-seq
MIRT2135727	hsa-miR-4330	CLIP-seq
MIRT1453075	hsa-miR-4419a	CLIP-seq
MIRT1453076	hsa-miR-4422	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2135728	hsa-miR-4434	CLIP-seq
MIRT1453080	hsa-miR-4438	CLIP-seq
MIRT1453082	hsa-miR-4446-3p	CLIP-seq
MIRT1453086	hsa-miR-4476	CLIP-seq
MIRT2135729	hsa-miR-4486	CLIP-seq
MIRT2135730	hsa-miR-4496	CLIP-seq
MIRT1453094	hsa-miR-4510	CLIP-seq
MIRT1453095	hsa-miR-4515	CLIP-seq
MIRT2135731	hsa-miR-4516	CLIP-seq
MIRT2135732	hsa-miR-452	CLIP-seq
MIRT2135733	hsa-miR-4536	CLIP-seq
MIRT2135734	hsa-miR-4633-3p	CLIP-seq
MIRT1453098	hsa-miR-4639-3p	CLIP-seq
MIRT1453099	hsa-miR-4639-5p	CLIP-seq
MIRT1453100	hsa-miR-4640-5p	CLIP-seq
MIRT2135735	hsa-miR-4644	CLIP-seq
MIRT2135736	hsa-miR-4676-3p	CLIP-seq
MIRT1453110	hsa-miR-4710	CLIP-seq
MIRT2135737	hsa-miR-4718	CLIP-seq
MIRT2135738	hsa-miR-4726-3p	CLIP-seq
MIRT1453112	hsa-miR-4726-5p	CLIP-seq
MIRT2135739	hsa-miR-4735-3p	CLIP-seq
MIRT2135740	hsa-miR-4753-5p	CLIP-seq
MIRT2135741	hsa-miR-4762-3p	CLIP-seq
MIRT1453121	hsa-miR-4775	CLIP-seq
MIRT1453127	hsa-miR-501-3p	CLIP-seq
MIRT1453128	hsa-miR-502-3p	CLIP-seq
MIRT1453132	hsa-miR-5095	CLIP-seq
MIRT2135742	hsa-miR-520f	CLIP-seq
MIRT2135743	hsa-miR-544	CLIP-seq
MIRT2135744	hsa-miR-548u	CLIP-seq
MIRT2135745	hsa-miR-552	CLIP-seq
MIRT1453157	hsa-miR-590-3p	CLIP-seq
MIRT2135746	hsa-miR-604	CLIP-seq
MIRT2135747	hsa-miR-605	CLIP-seq
MIRT2135748	hsa-miR-612	CLIP-seq
MIRT2135749	hsa-miR-630	CLIP-seq
MIRT1453164	hsa-miR-661	CLIP-seq
MIRT2135750	hsa-miR-708	CLIP-seq
MIRT2135751	hsa-miR-873	CLIP-seq
MIRT2135752	hsa-miR-885-3p	CLIP-seq
MIRT1453171	hsa-miR-922	CLIP-seq
MIRT1453008	hsa-miR-1207-5p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT1453011	hsa-miR-124	CLIP-seq
MIRT2356886	hsa-miR-1273c	CLIP-seq
MIRT2356887	hsa-miR-1281	CLIP-seq
MIRT2356888	hsa-miR-1343	CLIP-seq
MIRT2135704	hsa-miR-1914	CLIP-seq
MIRT2356889	hsa-miR-196a	CLIP-seq
MIRT2356890	hsa-miR-196b	CLIP-seq
MIRT1453031	hsa-miR-216a	CLIP-seq
MIRT1453032	hsa-miR-2355-5p	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT2135709	hsa-miR-3152-5p	CLIP-seq
MIRT2356891	hsa-miR-3189-3p	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2356892	hsa-miR-3683	CLIP-seq
MIRT1453065	hsa-miR-3714	CLIP-seq
MIRT1453068	hsa-miR-3910	CLIP-seq
MIRT1453069	hsa-miR-3927	CLIP-seq
MIRT1453071	hsa-miR-4270	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT1453081	hsa-miR-4441	CLIP-seq
MIRT1453087	hsa-miR-4477b	CLIP-seq
MIRT1453100	hsa-miR-4640-5p	CLIP-seq
MIRT2356893	hsa-miR-4719	CLIP-seq
MIRT1453112	hsa-miR-4726-5p	CLIP-seq
MIRT1453117	hsa-miR-4763-3p	CLIP-seq
MIRT1453119	hsa-miR-4766-5p	CLIP-seq
MIRT1453124	hsa-miR-486-3p	CLIP-seq
MIRT1453126	hsa-miR-499a-5p	CLIP-seq
MIRT1453130	hsa-miR-506	CLIP-seq
MIRT1453132	hsa-miR-5095	CLIP-seq
MIRT2135747	hsa-miR-605	CLIP-seq
MIRT1453160	hsa-miR-642b	CLIP-seq
MIRT2135752	hsa-miR-885-3p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT2462335	hsa-miR-1307	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT2462336	hsa-miR-3650	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2462337	hsa-miR-4284	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2462338	hsa-miR-4638-5p	CLIP-seq
MIRT2462339	hsa-miR-4695-3p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT2462335	hsa-miR-1307	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT2462336	hsa-miR-3650	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2462337	hsa-miR-4284	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2462338	hsa-miR-4638-5p	CLIP-seq
MIRT2462339	hsa-miR-4695-3p	CLIP-seq
MIRT2650332	hsa-miR-4772-3p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT2462335	hsa-miR-1307	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT1453042	hsa-miR-3149	CLIP-seq
MIRT2462336	hsa-miR-3650	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2462337	hsa-miR-4284	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2462338	hsa-miR-4638-5p	CLIP-seq
MIRT2694117	hsa-miR-4659a-5p	CLIP-seq
MIRT2694118	hsa-miR-4659b-5p	CLIP-seq
MIRT2462339	hsa-miR-4695-3p	CLIP-seq
MIRT1453114	hsa-miR-4735-5p	CLIP-seq
MIRT2650332	hsa-miR-4772-3p	CLIP-seq
MIRT1453121	hsa-miR-4775	CLIP-seq
MIRT1453157	hsa-miR-590-3p	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	35145029
GO:0005737	Component	Cytoplasm	IDA	11331580
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0006954	Process	Inflammatory response	IDA	21914792
GO:0006954	Process	Inflammatory response	IDA	35145029
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032897	Process	Negative regulation of viral transcription	IDA	18248090
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IDA	18248090
GO:0045087	Process	Innate immune response	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060090	Function	Molecular adaptor activity	IDA	35145029
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0071108	Process	Protein K48-linked deubiquitination	IMP	18162577

MIM	HGNC	e!Ensembl
606556	16283	ENSG00000106785

Protein

UniProt ID

Q14142

Protein name

Tripartite motif-containing protein 14

Protein function

Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of v

PDB

6JBM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00643	zf-B_box	21 → 61	B-box zinc finger	Domain
PF13765	PRY	269 → 317	SPRY-associated domain	Family
PF00622	SPRY	321 → 438	SPRY domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highest expression in liver; undetectable in skeletal muscle.

Sequence

MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGAHRGHPVGL
ALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWLKGKFTELRL
LLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSISQEPDPVQRLQA
YTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLS
DPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPV
PVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGASAAARLGCNRQ
SWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRAT
FQEPLYPALRLWEGAISIPRLP

Sequence length

442

Interactions

View interactions

	Reactome
			Interferon gamma signaling

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Atherosclerosis	Associate	31070748, 33892646
Breast Neoplasms	Stimulate	29562956
Breast Neoplasms	Associate	33174608, 34787066
Carcinoma Non Small Cell Lung	Stimulate	26599082
Carcinoma Non Small Cell Lung	Associate	33174608
Fibrocartilaginous embolism	Associate	31322007
Glioblastoma	Associate	30728039
Glioma	Associate	33316781
Inflammation	Stimulate	31070748
Leukemia Myeloid Acute	Associate	34656078
Macular Degeneration	Associate	34534445
Melanoma	Stimulate	33982666
Neoplasms	Associate	29204446, 29562956, 30728039, 33982666
Osteosarcoma	Associate	33174608
Plaque Atherosclerotic	Stimulate	31070748
Spondylosis	Associate	31322007
Squamous Cell Carcinoma of Head and Neck	Associate	29204446
Uterine Cervical Neoplasms	Associate	33174608
Vascular Diseases	Associate	31070748

TRIM14 (tripartite motif containing 14)