Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	9806
Gene name	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Gene symbol	SPOCK2
Synonyms (NCBI Gene)	testican-2
Chromosome	10
Chromosome location	10q22.1
Summary	This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-

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miRTarBase ID	miRNA	Experiments	Reference
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT726465	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726464	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726463	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT734119	hsa-miR-363-3p	Microarray	31794425
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT1385102	hsa-miR-1229	CLIP-seq
MIRT1385103	hsa-miR-1287	CLIP-seq
MIRT1385104	hsa-miR-1321	CLIP-seq
MIRT1385105	hsa-miR-224	CLIP-seq
MIRT1385106	hsa-miR-3614-5p	CLIP-seq
MIRT1385107	hsa-miR-3652	CLIP-seq
MIRT1385108	hsa-miR-4419a	CLIP-seq
MIRT1385109	hsa-miR-4430	CLIP-seq
MIRT1385110	hsa-miR-4505	CLIP-seq
MIRT1385111	hsa-miR-4510	CLIP-seq
MIRT1385112	hsa-miR-4729	CLIP-seq
MIRT1385113	hsa-miR-4739	CLIP-seq
MIRT1385114	hsa-miR-4756-5p	CLIP-seq
MIRT1385115	hsa-miR-4785	CLIP-seq
MIRT1385116	hsa-miR-647	CLIP-seq
MIRT1385117	hsa-miR-1249	CLIP-seq
MIRT1385118	hsa-miR-1912	CLIP-seq
MIRT1385119	hsa-miR-3064-3p	CLIP-seq
MIRT1385120	hsa-miR-329	CLIP-seq
MIRT1385121	hsa-miR-362-3p	CLIP-seq
MIRT1385122	hsa-miR-3667-5p	CLIP-seq
MIRT1385123	hsa-miR-370	CLIP-seq
MIRT1385124	hsa-miR-4270	CLIP-seq
MIRT1385125	hsa-miR-4423-5p	CLIP-seq
MIRT1385126	hsa-miR-4441	CLIP-seq
MIRT1385127	hsa-miR-4632	CLIP-seq
MIRT1385128	hsa-miR-4763-5p	CLIP-seq
MIRT1385129	hsa-miR-4768-3p	CLIP-seq
MIRT1385130	hsa-miR-767-3p	CLIP-seq
MIRT1554109	hsa-miR-3179	CLIP-seq
MIRT1554110	hsa-miR-4323	CLIP-seq
MIRT1554111	hsa-miR-4761-3p	CLIP-seq
MIRT2115229	hsa-miR-1193	CLIP-seq
MIRT2115230	hsa-miR-1207-3p	CLIP-seq
MIRT2115231	hsa-miR-1237	CLIP-seq
MIRT2115232	hsa-miR-1243	CLIP-seq
MIRT2115233	hsa-miR-1248	CLIP-seq
MIRT2115234	hsa-miR-1275	CLIP-seq
MIRT2115235	hsa-miR-1293	CLIP-seq
MIRT2115236	hsa-miR-1302	CLIP-seq
MIRT2115237	hsa-miR-136	CLIP-seq
MIRT1385118	hsa-miR-1912	CLIP-seq
MIRT2115238	hsa-miR-1915	CLIP-seq
MIRT2115239	hsa-miR-1972	CLIP-seq
MIRT2115240	hsa-miR-1976	CLIP-seq
MIRT2115241	hsa-miR-2115	CLIP-seq
MIRT2115242	hsa-miR-3155	CLIP-seq
MIRT2115243	hsa-miR-3155b	CLIP-seq
MIRT1554109	hsa-miR-3179	CLIP-seq
MIRT2115244	hsa-miR-361-3p	CLIP-seq
MIRT2115245	hsa-miR-3620	CLIP-seq
MIRT1385123	hsa-miR-370	CLIP-seq
MIRT2115246	hsa-miR-377	CLIP-seq
MIRT2115247	hsa-miR-4267	CLIP-seq
MIRT2115248	hsa-miR-4269	CLIP-seq
MIRT2115249	hsa-miR-4298	CLIP-seq
MIRT1554110	hsa-miR-4323	CLIP-seq
MIRT2115250	hsa-miR-4447	CLIP-seq
MIRT2115251	hsa-miR-4472	CLIP-seq
MIRT2115252	hsa-miR-4483	CLIP-seq
MIRT2115253	hsa-miR-4525	CLIP-seq
MIRT2115254	hsa-miR-4537	CLIP-seq
MIRT2115255	hsa-miR-4663	CLIP-seq
MIRT2115256	hsa-miR-4665-5p	CLIP-seq
MIRT2115257	hsa-miR-4668-5p	CLIP-seq
MIRT2115258	hsa-miR-4694-3p	CLIP-seq
MIRT2115259	hsa-miR-4723-5p	CLIP-seq
MIRT2115260	hsa-miR-4726-3p	CLIP-seq
MIRT1554111	hsa-miR-4761-3p	CLIP-seq
MIRT2115261	hsa-miR-484	CLIP-seq
MIRT2115262	hsa-miR-508-5p	CLIP-seq
MIRT2115263	hsa-miR-515-5p	CLIP-seq
MIRT2115264	hsa-miR-516a-3p	CLIP-seq
MIRT2115265	hsa-miR-570	CLIP-seq
MIRT2115266	hsa-miR-574-3p	CLIP-seq
MIRT2115267	hsa-miR-625	CLIP-seq
MIRT2115268	hsa-miR-665	CLIP-seq
MIRT2115269	hsa-miR-7	CLIP-seq
MIRT2115270	hsa-miR-766	CLIP-seq
MIRT2115229	hsa-miR-1193	CLIP-seq
MIRT2115232	hsa-miR-1243	CLIP-seq
MIRT2115234	hsa-miR-1275	CLIP-seq
MIRT2115235	hsa-miR-1293	CLIP-seq
MIRT2337993	hsa-miR-3151	CLIP-seq
MIRT2115250	hsa-miR-4447	CLIP-seq
MIRT2115251	hsa-miR-4472	CLIP-seq
MIRT2115252	hsa-miR-4483	CLIP-seq
MIRT2115253	hsa-miR-4525	CLIP-seq
MIRT2337994	hsa-miR-4640-5p	CLIP-seq
MIRT2115256	hsa-miR-4665-5p	CLIP-seq
MIRT2115257	hsa-miR-4668-5p	CLIP-seq
MIRT2115259	hsa-miR-4723-5p	CLIP-seq
MIRT2337995	hsa-miR-4726-5p	CLIP-seq
MIRT2115265	hsa-miR-570	CLIP-seq
MIRT2115267	hsa-miR-625	CLIP-seq
MIRT2691903	hsa-miR-3065-3p	CLIP-seq
MIRT2115244	hsa-miR-361-3p	CLIP-seq
MIRT2691904	hsa-miR-3913-3p	CLIP-seq
MIRT2691905	hsa-miR-489	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IDA	10386950
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005518	Function	Collagen binding	IBA
GO:0005539	Function	Glycosaminoglycan binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007416	Process	Synapse assembly	NAS	10386950
GO:0008191	Function	Metalloendopeptidase inhibitor activity	IEA
GO:0008191	Function	Metalloendopeptidase inhibitor activity	TAS	12810672
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030198	Process	Extracellular matrix organization	NAS	10386950
GO:0031012	Component	Extracellular matrix	NAS	10386950
GO:0045595	Process	Regulation of cell differentiation	NAS	10386950
GO:0050840	Function	Extracellular matrix binding	IBA
GO:0050840	Function	Extracellular matrix binding	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:2000147	Process	Positive regulation of cell motility	TAS	12810672

MIM	HGNC	e!Ensembl
607988	13564	ENSG00000107742

Q92563

Protein name

Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2)

Protein function

May participate in diverse steps of neurogenesis. Binds calcium.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07648	Kazal_2	131 → 180	Kazal-type serine protease inhibitor domain	Domain
PF10591	SPARC_Ca_bdg	196 → 305	Secreted protein acidic and rich in cysteine Ca binding region	Domain
PF00086	Thyroglobulin_1	313 → 376	Thyroglobulin type-1 repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain. Also found in lung and testis. {ECO:0000269|PubMed:10386950}.

Sequence

MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
IKQPTVKLHGNKDSICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC
PCPTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPASGLDK
SLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTA
EWCFCFWREKPPCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQ
LGLELTGTRTHGSPDCDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDG
GYIW

Sequence length

424

Interactions

View interactions

SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2)