Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9806
Gene name Gene Name - the full gene name approved by the HGNC.	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPOCK2
Synonyms (NCBI Gene) Gene synonyms aliases	testican-2
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-

Show/Hide all(123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT726465	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726464	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726463	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT734119	hsa-miR-363-3p	Microarray	31794425
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT622130	hsa-miR-8485	HITS-CLIP	23824327
MIRT622129	hsa-miR-603	HITS-CLIP	23824327
MIRT622128	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT622127	hsa-miR-4643	HITS-CLIP	23824327
MIRT622126	hsa-miR-3941	HITS-CLIP	23824327
MIRT1385102	hsa-miR-1229	CLIP-seq
MIRT1385103	hsa-miR-1287	CLIP-seq
MIRT1385104	hsa-miR-1321	CLIP-seq
MIRT1385105	hsa-miR-224	CLIP-seq
MIRT1385106	hsa-miR-3614-5p	CLIP-seq
MIRT1385107	hsa-miR-3652	CLIP-seq
MIRT1385108	hsa-miR-4419a	CLIP-seq
MIRT1385109	hsa-miR-4430	CLIP-seq
MIRT1385110	hsa-miR-4505	CLIP-seq
MIRT1385111	hsa-miR-4510	CLIP-seq
MIRT1385112	hsa-miR-4729	CLIP-seq
MIRT1385113	hsa-miR-4739	CLIP-seq
MIRT1385114	hsa-miR-4756-5p	CLIP-seq
MIRT1385115	hsa-miR-4785	CLIP-seq
MIRT1385116	hsa-miR-647	CLIP-seq
MIRT1385117	hsa-miR-1249	CLIP-seq
MIRT1385118	hsa-miR-1912	CLIP-seq
MIRT1385119	hsa-miR-3064-3p	CLIP-seq
MIRT1385120	hsa-miR-329	CLIP-seq
MIRT1385121	hsa-miR-362-3p	CLIP-seq
MIRT1385122	hsa-miR-3667-5p	CLIP-seq
MIRT1385123	hsa-miR-370	CLIP-seq
MIRT1385124	hsa-miR-4270	CLIP-seq
MIRT1385125	hsa-miR-4423-5p	CLIP-seq
MIRT1385126	hsa-miR-4441	CLIP-seq
MIRT1385127	hsa-miR-4632	CLIP-seq
MIRT1385128	hsa-miR-4763-5p	CLIP-seq
MIRT1385129	hsa-miR-4768-3p	CLIP-seq
MIRT1385130	hsa-miR-767-3p	CLIP-seq
MIRT1554109	hsa-miR-3179	CLIP-seq
MIRT1554110	hsa-miR-4323	CLIP-seq
MIRT1554111	hsa-miR-4761-3p	CLIP-seq
MIRT2115229	hsa-miR-1193	CLIP-seq
MIRT2115230	hsa-miR-1207-3p	CLIP-seq
MIRT2115231	hsa-miR-1237	CLIP-seq
MIRT2115232	hsa-miR-1243	CLIP-seq
MIRT2115233	hsa-miR-1248	CLIP-seq
MIRT2115234	hsa-miR-1275	CLIP-seq
MIRT2115235	hsa-miR-1293	CLIP-seq
MIRT2115236	hsa-miR-1302	CLIP-seq
MIRT2115237	hsa-miR-136	CLIP-seq
MIRT1385118	hsa-miR-1912	CLIP-seq
MIRT2115238	hsa-miR-1915	CLIP-seq
MIRT2115239	hsa-miR-1972	CLIP-seq
MIRT2115240	hsa-miR-1976	CLIP-seq
MIRT2115241	hsa-miR-2115	CLIP-seq
MIRT2115242	hsa-miR-3155	CLIP-seq
MIRT2115243	hsa-miR-3155b	CLIP-seq
MIRT1554109	hsa-miR-3179	CLIP-seq
MIRT2115244	hsa-miR-361-3p	CLIP-seq
MIRT2115245	hsa-miR-3620	CLIP-seq
MIRT1385123	hsa-miR-370	CLIP-seq
MIRT2115246	hsa-miR-377	CLIP-seq
MIRT2115247	hsa-miR-4267	CLIP-seq
MIRT2115248	hsa-miR-4269	CLIP-seq
MIRT2115249	hsa-miR-4298	CLIP-seq
MIRT1554110	hsa-miR-4323	CLIP-seq
MIRT2115250	hsa-miR-4447	CLIP-seq
MIRT2115251	hsa-miR-4472	CLIP-seq
MIRT2115252	hsa-miR-4483	CLIP-seq
MIRT2115253	hsa-miR-4525	CLIP-seq
MIRT2115254	hsa-miR-4537	CLIP-seq
MIRT2115255	hsa-miR-4663	CLIP-seq
MIRT2115256	hsa-miR-4665-5p	CLIP-seq
MIRT2115257	hsa-miR-4668-5p	CLIP-seq
MIRT2115258	hsa-miR-4694-3p	CLIP-seq
MIRT2115259	hsa-miR-4723-5p	CLIP-seq
MIRT2115260	hsa-miR-4726-3p	CLIP-seq
MIRT1554111	hsa-miR-4761-3p	CLIP-seq
MIRT2115261	hsa-miR-484	CLIP-seq
MIRT2115262	hsa-miR-508-5p	CLIP-seq
MIRT2115263	hsa-miR-515-5p	CLIP-seq
MIRT2115264	hsa-miR-516a-3p	CLIP-seq
MIRT2115265	hsa-miR-570	CLIP-seq
MIRT2115266	hsa-miR-574-3p	CLIP-seq
MIRT2115267	hsa-miR-625	CLIP-seq
MIRT2115268	hsa-miR-665	CLIP-seq
MIRT2115269	hsa-miR-7	CLIP-seq
MIRT2115270	hsa-miR-766	CLIP-seq
MIRT2115229	hsa-miR-1193	CLIP-seq
MIRT2115232	hsa-miR-1243	CLIP-seq
MIRT2115234	hsa-miR-1275	CLIP-seq
MIRT2115235	hsa-miR-1293	CLIP-seq
MIRT2337993	hsa-miR-3151	CLIP-seq
MIRT2115250	hsa-miR-4447	CLIP-seq
MIRT2115251	hsa-miR-4472	CLIP-seq
MIRT2115252	hsa-miR-4483	CLIP-seq
MIRT2115253	hsa-miR-4525	CLIP-seq
MIRT2337994	hsa-miR-4640-5p	CLIP-seq
MIRT2115256	hsa-miR-4665-5p	CLIP-seq
MIRT2115257	hsa-miR-4668-5p	CLIP-seq
MIRT2115259	hsa-miR-4723-5p	CLIP-seq
MIRT2337995	hsa-miR-4726-5p	CLIP-seq
MIRT2115265	hsa-miR-570	CLIP-seq
MIRT2115267	hsa-miR-625	CLIP-seq
MIRT2691903	hsa-miR-3065-3p	CLIP-seq
MIRT2115244	hsa-miR-361-3p	CLIP-seq
MIRT2691904	hsa-miR-3913-3p	CLIP-seq
MIRT2691905	hsa-miR-489	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IDA	10386950
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005539	Function	Glycosaminoglycan binding	IEA
GO:0007416	Process	Synapse assembly	NAS	10386950
GO:0008191	Function	Metalloendopeptidase inhibitor activity	TAS	12810672
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	TAS	12810672
GO:0019800	Process	Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	IEA
GO:0030198	Process	Extracellular matrix organization	NAS	10386950
GO:0031012	Component	Extracellular matrix	NAS	10386950
GO:0045595	Process	Regulation of cell differentiation	NAS	10386950
GO:0050840	Function	Extracellular matrix binding	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:2000147	Process	Positive regulation of cell motility	TAS	12810672

MIM	HGNC	e!Ensembl
607988	13564	ENSG00000107742

Protein

UniProt ID

Q92563

Protein name

Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2)

Protein function

May participate in diverse steps of neurogenesis. Binds calcium.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07648	Kazal_2	131 → 180	Kazal-type serine protease inhibitor domain	Domain
PF10591	SPARC_Ca_bdg	196 → 305	Secreted protein acidic and rich in cysteine Ca binding region	Domain
PF00086	Thyroglobulin_1	313 → 376	Thyroglobulin type-1 repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain. Also found in lung and testis. {ECO:0000269|PubMed:10386950}.

Sequence

MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
IKQPTVKLHGNKDSICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC
PCPTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPASGLDK
SLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTA
EWCFCFWREKPPCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQ
LGLELTGTRTHGSPDCDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDG
GYIW

Sequence length

424

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.	GWAS, CBGDA
Diabetes	Diabetes		GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Inhibit	36629984
Airway Remodeling	Associate	37165378
Back Pain	Associate	30747904
Breast Neoplasms	Associate	18446232
Carcinoma Pancreatic Ductal	Associate	33761652
Carcinoma Pancreatic Ductal	Inhibit	37188984
Colorectal Neoplasms	Associate	18446232
Endometriosis	Associate	32851893
Inflammation	Associate	21470430
Lupus Erythematosus Systemic	Associate	37841281
Neoplasms	Associate	18446232, 28540987
Neoplasms	Inhibit	36629984, 36973285
Ovarian Diseases	Associate	25298284
Ovarian Neoplasms	Associate	31794425, 36193300
Prostatic Neoplasms	Associate	18446232
Squamous Cell Carcinoma of Head and Neck	Associate	38157249
Tuberculosis	Associate	28794177

SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2)