Gene Gene information from NCBI Gene database.
Entrez ID 9777
Gene name Transmembrane 9 superfamily member 4
Gene symbol TM9SF4
Synonyms (NCBI Gene)
dJ836N17.2
Chromosome 20
Chromosome location 20q11.21
miRNA miRNA information provided by mirtarbase database.
488
miRTarBase ID miRNA Experiments Reference
MIRT036460 hsa-miR-1226-3p CLASH 23622248
MIRT652530 hsa-miR-4311 HITS-CLIP 23824327
MIRT652529 hsa-miR-216b-5p HITS-CLIP 23824327
MIRT652528 hsa-miR-3123 HITS-CLIP 23824327
MIRT652527 hsa-miR-5584-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IDA 25961573
GO:0005515 Function Protein binding IPI 25659576, 28514442, 29125601, 33961781
GO:0005768 Component Endosome IEA
GO:0005769 Component Early endosome IDA 19893578
GO:0005769 Component Early endosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617727 30797 ENSG00000101337
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92544
Protein name Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)
Protein function Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02990 EMP70 55 599 Endomembrane protein 70 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and gran
Sequence
Sequence length 642
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autism spectrum disorder Likely benign rs941851420 RCV003127375
Familial cancer of breast Uncertain significance rs779542159 RCV005939265
TM9SF4-related disorder Uncertain significance rs2516093039, rs1356160798 RCV003406175
RCV003402118
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Calcinosis Cutis Stimulate 25961573
Hypoxia Inhibit 25961573
Leukemia Associate 25961573
Leukemia Myeloid Acute Stimulate 25961573
Melanoma Associate 19893578
Melanoma Stimulate 25961573
Myelodysplastic Syndromes Stimulate 25961573
Neoplasm Metastasis Associate 35655258
Neoplasms Associate 19893578
Prostatic Neoplasms Associate 35655258