Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9770
Gene name Gene Name - the full gene name approved by the HGNC.	Ras association domain family member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RASSF2
Synonyms (NCBI Gene) Gene synonyms aliases	CENP-34, RASFADIN
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20p13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by Re

Show/Hide all(226)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016642	hsa-miR-429	Reporter assay	20005803
MIRT020352	hsa-miR-200a-3p	Reporter assay	20005803
MIRT021074	hsa-miR-200c-3p	Reporter assay	20005803
MIRT021654	hsa-miR-141-3p	Reporter assay	20005803
MIRT022828	hsa-miR-124-3p	Microarray	18668037
MIRT024131	hsa-miR-200b-3p	Reporter assay	20005803
MIRT031279	hsa-miR-19b-3p	Sequencing	20371350
MIRT721937	hsa-miR-8485	HITS-CLIP	19536157
MIRT721936	hsa-miR-6768-5p	HITS-CLIP	19536157
MIRT721935	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT399569	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT721934	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT721933	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT654422	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT654420	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT654421	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT654419	hsa-miR-3612	HITS-CLIP	23824327
MIRT654418	hsa-miR-650	HITS-CLIP	23824327
MIRT654416	hsa-miR-4443	HITS-CLIP	23824327
MIRT654417	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT154043	hsa-miR-15a-5p	PAR-CLIP	23708386
MIRT154048	hsa-miR-15b-5p	PAR-CLIP	23708386
MIRT154044	hsa-miR-16-5p	PAR-CLIP	23708386
MIRT154051	hsa-miR-195-5p	PAR-CLIP	23708386
MIRT154054	hsa-miR-424-5p	PAR-CLIP	23708386
MIRT154056	hsa-miR-497-5p	PAR-CLIP	23708386
MIRT154073	hsa-miR-6838-5p	PAR-CLIP	23708386
MIRT495037	hsa-miR-455-5p	PAR-CLIP	23708386
MIRT495036	hsa-miR-5589-3p	PAR-CLIP	23708386
MIRT495034	hsa-miR-4480	PAR-CLIP	23708386
MIRT495035	hsa-miR-1227-3p	PAR-CLIP	23708386
MIRT726782	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT031279	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT737391	hsa-miR-1178-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), RNA-seq, qRT-PCR	32059341
MIRT721937	hsa-miR-8485	HITS-CLIP	19536157
MIRT721936	hsa-miR-6768-5p	HITS-CLIP	19536157
MIRT721935	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT399569	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT721934	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT721933	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT654422	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT654420	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT654421	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT654419	hsa-miR-3612	HITS-CLIP	23824327
MIRT654418	hsa-miR-650	HITS-CLIP	23824327
MIRT654416	hsa-miR-4443	HITS-CLIP	23824327
MIRT654417	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT154043	hsa-miR-15a-5p	PAR-CLIP	23708386
MIRT154048	hsa-miR-15b-5p	PAR-CLIP	23708386
MIRT154044	hsa-miR-16-5p	PAR-CLIP	23708386
MIRT154051	hsa-miR-195-5p	PAR-CLIP	23708386
MIRT154054	hsa-miR-424-5p	PAR-CLIP	23708386
MIRT154056	hsa-miR-497-5p	PAR-CLIP	23708386
MIRT154073	hsa-miR-6838-5p	PAR-CLIP	23708386
MIRT495037	hsa-miR-455-5p	PAR-CLIP	23708386
MIRT495036	hsa-miR-5589-3p	PAR-CLIP	23708386
MIRT495034	hsa-miR-4480	PAR-CLIP	23708386
MIRT495035	hsa-miR-1227-3p	PAR-CLIP	23708386
MIRT1292690	hsa-miR-1908	CLIP-seq
MIRT1292691	hsa-miR-339-5p	CLIP-seq
MIRT1292692	hsa-miR-3621	CLIP-seq
MIRT1292693	hsa-miR-4267	CLIP-seq
MIRT1292694	hsa-miR-663	CLIP-seq
MIRT1292695	hsa-miR-1224-3p	CLIP-seq
MIRT1292696	hsa-miR-1260	CLIP-seq
MIRT1292697	hsa-miR-1260b	CLIP-seq
MIRT1292698	hsa-miR-128	CLIP-seq
MIRT1292699	hsa-miR-1280	CLIP-seq
MIRT1292700	hsa-miR-1285	CLIP-seq
MIRT1292701	hsa-miR-1291	CLIP-seq
MIRT1292702	hsa-miR-146b-3p	CLIP-seq
MIRT1292703	hsa-miR-2052	CLIP-seq
MIRT1292704	hsa-miR-24	CLIP-seq
MIRT1292705	hsa-miR-3153	CLIP-seq
MIRT1292706	hsa-miR-3163	CLIP-seq
MIRT1292707	hsa-miR-3183	CLIP-seq
MIRT1292708	hsa-miR-3187-5p	CLIP-seq
MIRT1292709	hsa-miR-323-5p	CLIP-seq
MIRT1292691	hsa-miR-339-5p	CLIP-seq
MIRT1292710	hsa-miR-3615	CLIP-seq
MIRT1292711	hsa-miR-3652	CLIP-seq
MIRT1292712	hsa-miR-374a	CLIP-seq
MIRT1292713	hsa-miR-374b	CLIP-seq
MIRT1292714	hsa-miR-3926	CLIP-seq
MIRT1292715	hsa-miR-4261	CLIP-seq
MIRT1292716	hsa-miR-4284	CLIP-seq
MIRT1292717	hsa-miR-4287	CLIP-seq
MIRT1292718	hsa-miR-4426	CLIP-seq
MIRT1292719	hsa-miR-4428	CLIP-seq
MIRT1292720	hsa-miR-4430	CLIP-seq
MIRT1292721	hsa-miR-4433	CLIP-seq
MIRT1292722	hsa-miR-4476	CLIP-seq
MIRT1292723	hsa-miR-4505	CLIP-seq
MIRT1292724	hsa-miR-4533	CLIP-seq
MIRT1292725	hsa-miR-4646-5p	CLIP-seq
MIRT1292726	hsa-miR-4647	CLIP-seq
MIRT1292727	hsa-miR-4649-3p	CLIP-seq
MIRT1292728	hsa-miR-4662b	CLIP-seq
MIRT1292729	hsa-miR-4663	CLIP-seq
MIRT1292730	hsa-miR-4668-5p	CLIP-seq
MIRT1292731	hsa-miR-4685-3p	CLIP-seq
MIRT1292732	hsa-miR-4723-3p	CLIP-seq
MIRT1292733	hsa-miR-4733-5p	CLIP-seq
MIRT1292734	hsa-miR-4753-3p	CLIP-seq
MIRT1292735	hsa-miR-4766-5p	CLIP-seq
MIRT1292736	hsa-miR-4780	CLIP-seq
MIRT1292737	hsa-miR-4793-3p	CLIP-seq
MIRT1292738	hsa-miR-4802-5p	CLIP-seq
MIRT1292739	hsa-miR-488	CLIP-seq
MIRT1292740	hsa-miR-508-5p	CLIP-seq
MIRT1292741	hsa-miR-548aa	CLIP-seq
MIRT1292742	hsa-miR-548an	CLIP-seq
MIRT1292743	hsa-miR-548s	CLIP-seq
MIRT1292744	hsa-miR-612	CLIP-seq
MIRT1292745	hsa-miR-623	CLIP-seq
MIRT1292746	hsa-miR-628-5p	CLIP-seq
MIRT1292747	hsa-miR-647	CLIP-seq
MIRT1292748	hsa-miR-661	CLIP-seq
MIRT1292749	hsa-miR-765	CLIP-seq
MIRT1292750	hsa-miR-766	CLIP-seq
MIRT1292751	hsa-miR-876-3p	CLIP-seq
MIRT1552955	hsa-miR-3689a-3p	CLIP-seq
MIRT1552956	hsa-miR-3689c	CLIP-seq
MIRT1552957	hsa-miR-4728-5p	CLIP-seq
MIRT2086930	hsa-miR-3117-5p	CLIP-seq
MIRT2086931	hsa-miR-3122	CLIP-seq
MIRT2086932	hsa-miR-3135	CLIP-seq
MIRT2086933	hsa-miR-3150b-3p	CLIP-seq
MIRT2086934	hsa-miR-3616-5p	CLIP-seq
MIRT2086935	hsa-miR-3647-5p	CLIP-seq
MIRT1552955	hsa-miR-3689a-3p	CLIP-seq
MIRT1552956	hsa-miR-3689c	CLIP-seq
MIRT2086936	hsa-miR-3913-5p	CLIP-seq
MIRT1292714	hsa-miR-3926	CLIP-seq
MIRT1292718	hsa-miR-4426	CLIP-seq
MIRT1292721	hsa-miR-4433	CLIP-seq
MIRT1292726	hsa-miR-4647	CLIP-seq
MIRT1292728	hsa-miR-4662b	CLIP-seq
MIRT1552957	hsa-miR-4728-5p	CLIP-seq
MIRT1292733	hsa-miR-4733-5p	CLIP-seq
MIRT2086937	hsa-miR-4784	CLIP-seq
MIRT2086938	hsa-miR-499a-5p	CLIP-seq
MIRT2086939	hsa-miR-539	CLIP-seq
MIRT1292743	hsa-miR-548s	CLIP-seq
MIRT2086940	hsa-miR-573	CLIP-seq
MIRT2086941	hsa-miR-513b	CLIP-seq
MIRT2311873	hsa-miR-1237	CLIP-seq
MIRT2311874	hsa-miR-1248	CLIP-seq
MIRT2311875	hsa-miR-1909	CLIP-seq
MIRT2311876	hsa-miR-194	CLIP-seq
MIRT2311877	hsa-miR-2116	CLIP-seq
MIRT2086931	hsa-miR-3122	CLIP-seq
MIRT2311878	hsa-miR-3124-3p	CLIP-seq
MIRT2311879	hsa-miR-3126-5p	CLIP-seq
MIRT2086932	hsa-miR-3135	CLIP-seq
MIRT1292705	hsa-miR-3153	CLIP-seq
MIRT2311880	hsa-miR-3182	CLIP-seq
MIRT1292691	hsa-miR-339-5p	CLIP-seq
MIRT1552955	hsa-miR-3689a-3p	CLIP-seq
MIRT1552956	hsa-miR-3689c	CLIP-seq
MIRT2086936	hsa-miR-3913-5p	CLIP-seq
MIRT2311881	hsa-miR-4299	CLIP-seq
MIRT2311882	hsa-miR-4310	CLIP-seq
MIRT2311883	hsa-miR-4419a	CLIP-seq
MIRT2311884	hsa-miR-4420	CLIP-seq
MIRT1292721	hsa-miR-4433	CLIP-seq
MIRT2311885	hsa-miR-4456	CLIP-seq
MIRT2311886	hsa-miR-4510	CLIP-seq
MIRT1292730	hsa-miR-4668-5p	CLIP-seq
MIRT2311887	hsa-miR-4677-5p	CLIP-seq
MIRT2311888	hsa-miR-4710	CLIP-seq
MIRT1552957	hsa-miR-4728-5p	CLIP-seq
MIRT2311889	hsa-miR-4792	CLIP-seq
MIRT2311890	hsa-miR-495	CLIP-seq
MIRT2086939	hsa-miR-539	CLIP-seq
MIRT2311891	hsa-miR-548q	CLIP-seq
MIRT2311892	hsa-miR-645	CLIP-seq
MIRT1292714	hsa-miR-3926	CLIP-seq
MIRT1292718	hsa-miR-4426	CLIP-seq
MIRT1292721	hsa-miR-4433	CLIP-seq
MIRT1292726	hsa-miR-4647	CLIP-seq
MIRT1292728	hsa-miR-4662b	CLIP-seq
MIRT1292743	hsa-miR-548s	CLIP-seq
MIRT1292747	hsa-miR-647	CLIP-seq
MIRT2393511	hsa-miR-767-3p	CLIP-seq
MIRT1292698	hsa-miR-128	CLIP-seq
MIRT1292700	hsa-miR-1285	CLIP-seq
MIRT1292704	hsa-miR-24	CLIP-seq
MIRT2086931	hsa-miR-3122	CLIP-seq
MIRT2086932	hsa-miR-3135	CLIP-seq
MIRT1292708	hsa-miR-3187-5p	CLIP-seq
MIRT1292711	hsa-miR-3652	CLIP-seq
MIRT2608288	hsa-miR-3664-5p	CLIP-seq
MIRT1552955	hsa-miR-3689a-3p	CLIP-seq
MIRT1552956	hsa-miR-3689c	CLIP-seq
MIRT2608289	hsa-miR-371-5p	CLIP-seq
MIRT2608290	hsa-miR-371b-5p	CLIP-seq
MIRT2086936	hsa-miR-3913-5p	CLIP-seq
MIRT1292714	hsa-miR-3926	CLIP-seq
MIRT1292716	hsa-miR-4284	CLIP-seq
MIRT1292718	hsa-miR-4426	CLIP-seq
MIRT1292720	hsa-miR-4430	CLIP-seq
MIRT1292721	hsa-miR-4433	CLIP-seq
MIRT1292723	hsa-miR-4505	CLIP-seq
MIRT2608291	hsa-miR-4522	CLIP-seq
MIRT1292726	hsa-miR-4647	CLIP-seq
MIRT1292728	hsa-miR-4662b	CLIP-seq
MIRT1552957	hsa-miR-4728-5p	CLIP-seq
MIRT1292733	hsa-miR-4733-5p	CLIP-seq
MIRT1292734	hsa-miR-4753-3p	CLIP-seq
MIRT2608292	hsa-miR-4768-5p	CLIP-seq
MIRT1292743	hsa-miR-548s	CLIP-seq
MIRT1292744	hsa-miR-612	CLIP-seq
MIRT1292747	hsa-miR-647	CLIP-seq
MIRT2086931	hsa-miR-3122	CLIP-seq
MIRT2086932	hsa-miR-3135	CLIP-seq
MIRT2608288	hsa-miR-3664-5p	CLIP-seq
MIRT1552955	hsa-miR-3689a-3p	CLIP-seq
MIRT1552956	hsa-miR-3689c	CLIP-seq
MIRT2608289	hsa-miR-371-5p	CLIP-seq
MIRT2608290	hsa-miR-371b-5p	CLIP-seq
MIRT2086936	hsa-miR-3913-5p	CLIP-seq
MIRT1292721	hsa-miR-4433	CLIP-seq
MIRT2608291	hsa-miR-4522	CLIP-seq
MIRT1552957	hsa-miR-4728-5p	CLIP-seq
MIRT1292733	hsa-miR-4733-5p	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000776	Component	Kinetochore	IDA	20813266
GO:0000777	Component	Condensed chromosome kinetochore	IEA
GO:0001501	Process	Skeletal system development	IEA
GO:0001503	Process	Ossification	IEA
GO:0004672	Function	Protein kinase activity	IGI	19962960
GO:0005515	Function	Protein binding	IPI	12732644, 19525978, 20562859, 20920251, 23386615, 23455922, 23455924, 24255178, 24366813, 24981860, 25416956, 28514442, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19525978
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	19525978
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0031954	Process	Positive regulation of protein autophosphorylation	IDA	19962960
GO:0032991	Component	Protein-containing complex	IDA	19962960
GO:0033137	Process	Negative regulation of peptidyl-serine phosphorylation	IDA	19962960
GO:0038168	Process	Epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	19962960
GO:0045667	Process	Regulation of osteoblast differentiation	IEA
GO:0045670	Process	Regulation of osteoclast differentiation	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	IBA	21873635
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	19962960
GO:0046330	Process	Positive regulation of JNK cascade	IBA	21873635
GO:0046330	Process	Positive regulation of JNK cascade	IDA	19962960
GO:0046849	Process	Bone remodeling	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0050821	Process	Protein stabilization	IMP	19525978
GO:1901222	Process	Regulation of NIK/NF-kappaB signaling	IBA	21873635
GO:1901223	Process	Negative regulation of NIK/NF-kappaB signaling	IEA

MIM	HGNC	e!Ensembl
609492	9883	ENSG00000101265

Protein

UniProt ID

P50749

Protein name

Ras association domain-containing protein 2

Protein function

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00788	RA	176 → 264	Ras association (RalGDS/AF-6) domain	Domain
PF16517	Nore1-SARAH	277 → 316	Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. {ECO:0000269|PubMed:12732644}.

Sequence

MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW
GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ
MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT
SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY
PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK
LMRKYTVLRLMIRQRLEEIAETPATI

Sequence length

326

Interactions

View interactions

	KEGG
	Hippo signaling pathway - multiple species

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).	GWAS, CBGDA
Systemic lupus erythematosus	Systemic lupus erythematosus		GWAS
Dementia	Dementia		GWAS

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Associate	17923875, 19700653
Brain Neoplasms	Associate	25482183
Breast Neoplasms	Associate	23542458, 25482183, 26284587
Breast Neoplasms	Stimulate	34180753
Carcinogenesis	Associate	19700653, 20920251
Carcinoma Hepatocellular	Associate	18161048
Colorectal Neoplasms	Associate	19700653
Diabetes Mellitus Type 2	Associate	34560403
Fibrosis	Associate	35222428
Gastrointestinal Neoplasms	Associate	19700653
Glioma	Associate	25621889
Idiopathic Pulmonary Fibrosis	Associate	35222428
Lupus Erythematosus Systemic	Associate	24871463
Lymphatic Metastasis	Associate	34155937
Lymphatic Metastasis	Stimulate	34180753
Melanoma	Associate	22113481
Neoplasm Metastasis	Inhibit	18294275
Neoplasm Metastasis	Stimulate	34180753
Neoplasms	Inhibit	16265349, 20534969, 20920251, 22695170, 23887284, 25298284, 25621889
Neoplasms	Associate	17923875, 18294275, 22984959, 23542458, 26284587, 27901488
Neoplasms Squamous Cell	Associate	23542458
Neuroblastoma	Associate	22695170, 22984959
Ovarian Diseases	Associate	25298284
Ovarian Neoplasms	Associate	25298284
Prostatic Neoplasms	Associate	38493315
Retinoblastoma	Associate	26662407
Sarcoma Ewing	Associate	23887284, 24005033
Squamous Cell Carcinoma of Head and Neck	Inhibit	18294275
Stomach Neoplasms	Associate	16265349, 19700653, 34155937
Thyroid Neoplasms	Inhibit	20920251
Uterine Cervical Neoplasms	Inhibit	23542458

RASSF2 (Ras association domain family member 2)