Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9755
Gene name Gene Name - the full gene name approved by the HGNC.	TBK1 binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TBKBP1
Synonyms (NCBI Gene) Gene synonyms aliases	ProSAPiP2, SINTBAD
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.	TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

Show/Hide all(160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017616	hsa-miR-335-5p	Microarray	18185580
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT1414252	hsa-miR-1224-3p	CLIP-seq
MIRT1414253	hsa-miR-1275	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414255	hsa-miR-2467-3p	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1414259	hsa-miR-3144-5p	CLIP-seq
MIRT1414260	hsa-miR-3174	CLIP-seq
MIRT1414261	hsa-miR-3191	CLIP-seq
MIRT1414262	hsa-miR-3192	CLIP-seq
MIRT1414263	hsa-miR-3609	CLIP-seq
MIRT1414264	hsa-miR-3659	CLIP-seq
MIRT1414265	hsa-miR-3689a-3p	CLIP-seq
MIRT1414266	hsa-miR-3689c	CLIP-seq
MIRT1414267	hsa-miR-3714	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT1414271	hsa-miR-3973	CLIP-seq
MIRT1414272	hsa-miR-4260	CLIP-seq
MIRT1414273	hsa-miR-4292	CLIP-seq
MIRT1414274	hsa-miR-4419a	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT1414277	hsa-miR-4510	CLIP-seq
MIRT1414278	hsa-miR-4640-3p	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414280	hsa-miR-4652-5p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT1414282	hsa-miR-4658	CLIP-seq
MIRT1414283	hsa-miR-4665-5p	CLIP-seq
MIRT1414284	hsa-miR-4667-5p	CLIP-seq
MIRT1414285	hsa-miR-4690-3p	CLIP-seq
MIRT1414286	hsa-miR-4700-5p	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT1414288	hsa-miR-4728-5p	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1414290	hsa-miR-520g	CLIP-seq
MIRT1414291	hsa-miR-520h	CLIP-seq
MIRT1414292	hsa-miR-548ah	CLIP-seq
MIRT1414293	hsa-miR-548an	CLIP-seq
MIRT1414294	hsa-miR-574-5p	CLIP-seq
MIRT1414295	hsa-miR-661	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq
MIRT1554480	hsa-miR-148a	CLIP-seq
MIRT1554481	hsa-miR-148b	CLIP-seq
MIRT1554482	hsa-miR-152	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1554483	hsa-miR-3616-3p	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1554484	hsa-miR-4459	CLIP-seq
MIRT1554485	hsa-miR-4688	CLIP-seq
MIRT1554486	hsa-miR-4733-3p	CLIP-seq
MIRT1554487	hsa-miR-4755-3p	CLIP-seq
MIRT1554488	hsa-miR-4761-3p	CLIP-seq
MIRT1554489	hsa-miR-4779	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1554490	hsa-miR-665	CLIP-seq
MIRT2124278	hsa-miR-1286	CLIP-seq
MIRT2124279	hsa-miR-1289	CLIP-seq
MIRT2124280	hsa-miR-1825	CLIP-seq
MIRT2124281	hsa-miR-199a-5p	CLIP-seq
MIRT2124282	hsa-miR-199b-5p	CLIP-seq
MIRT2124283	hsa-miR-28-5p	CLIP-seq
MIRT2124284	hsa-miR-296-3p	CLIP-seq
MIRT2124285	hsa-miR-3139	CLIP-seq
MIRT2124286	hsa-miR-3154	CLIP-seq
MIRT2124287	hsa-miR-3185	CLIP-seq
MIRT2124288	hsa-miR-3190	CLIP-seq
MIRT2124289	hsa-miR-3198	CLIP-seq
MIRT2124290	hsa-miR-3690	CLIP-seq
MIRT2124291	hsa-miR-3909	CLIP-seq
MIRT2124292	hsa-miR-3925-3p	CLIP-seq
MIRT2124293	hsa-miR-3929	CLIP-seq
MIRT2124294	hsa-miR-4254	CLIP-seq
MIRT2124295	hsa-miR-4283	CLIP-seq
MIRT2124296	hsa-miR-4294	CLIP-seq
MIRT2124297	hsa-miR-4309	CLIP-seq
MIRT2124298	hsa-miR-4419b	CLIP-seq
MIRT2124299	hsa-miR-4478	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT2124300	hsa-miR-4722-5p	CLIP-seq
MIRT2124301	hsa-miR-7	CLIP-seq
MIRT2124302	hsa-miR-708	CLIP-seq
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT2346567	hsa-miR-122	CLIP-seq
MIRT2346568	hsa-miR-1912	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT2346569	hsa-miR-3127-3p	CLIP-seq
MIRT2346570	hsa-miR-3160-3p	CLIP-seq
MIRT2346571	hsa-miR-3179	CLIP-seq
MIRT1414262	hsa-miR-3192	CLIP-seq
MIRT2346572	hsa-miR-3202	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT2346573	hsa-miR-3919	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT2346574	hsa-miR-3936	CLIP-seq
MIRT1414272	hsa-miR-4260	CLIP-seq
MIRT2346575	hsa-miR-4329	CLIP-seq
MIRT2346576	hsa-miR-4426	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT2346577	hsa-miR-4647	CLIP-seq
MIRT2346578	hsa-miR-4648	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT2346579	hsa-miR-4654	CLIP-seq
MIRT2346580	hsa-miR-4662b	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT2346581	hsa-miR-4747-5p	CLIP-seq
MIRT2346582	hsa-miR-4756-3p	CLIP-seq
MIRT2346583	hsa-miR-4769-5p	CLIP-seq
MIRT2346584	hsa-miR-4786-5p	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1414294	hsa-miR-574-5p	CLIP-seq
MIRT2346585	hsa-miR-769-5p	CLIP-seq
MIRT2346586	hsa-miR-939	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	14743216, 17568778, 21903422, 21931555, 27980081, 32707033
GO:0005737	Component	Cytoplasm	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	NAS	21931631
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	21931631
GO:1902554	Component	Serine/threonine protein kinase complex	NAS	21931631

MIM	HGNC	e!Ensembl
608476	30140	ENSG00000198933

Protein

UniProt ID

A7MCY6

Protein name

TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)

Protein function

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12845	TBD	288 → 342	TBD domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus. {ECO:0000269|PubMed:17568778}.

Sequence

MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLER
ENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKN
KEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAF
SNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEA
RGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTE
LTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPC
PPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPS
CPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQ
AEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTI
RCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDD
ALIKHIDSHLENSKI

Sequence length

615

Interactions

View interactions

	KEGG
	RIG-I-like receptor signaling pathway

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Ankylosing Spondylitis	Ankylosing spondylitis	N/A	N/A	GWAS
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Low Tension Glaucoma	Associate	23286385
Spondylitis Ankylosing	Associate	23637848

TBKBP1 (TBK1 binding protein 1)