TBKBP1 (TBK1 binding protein 1)

Gene

• Entrez ID: 9755
• Gene name: TBK1 binding protein 1
• Gene symbol: TBKBP1
• Synonyms (NCBI Gene): ProSAPiP2, SINTBAD
• Chromosome: 17
• Chromosome location: 17q21.32
• Summary: TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017616	hsa-miR-335-5p	Microarray	18185580
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT1414252	hsa-miR-1224-3p	CLIP-seq
MIRT1414253	hsa-miR-1275	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414255	hsa-miR-2467-3p	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1414259	hsa-miR-3144-5p	CLIP-seq
MIRT1414260	hsa-miR-3174	CLIP-seq
MIRT1414261	hsa-miR-3191	CLIP-seq
MIRT1414262	hsa-miR-3192	CLIP-seq
MIRT1414263	hsa-miR-3609	CLIP-seq
MIRT1414264	hsa-miR-3659	CLIP-seq
MIRT1414265	hsa-miR-3689a-3p	CLIP-seq
MIRT1414266	hsa-miR-3689c	CLIP-seq
MIRT1414267	hsa-miR-3714	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT1414271	hsa-miR-3973	CLIP-seq
MIRT1414272	hsa-miR-4260	CLIP-seq
MIRT1414273	hsa-miR-4292	CLIP-seq
MIRT1414274	hsa-miR-4419a	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT1414277	hsa-miR-4510	CLIP-seq
MIRT1414278	hsa-miR-4640-3p	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414280	hsa-miR-4652-5p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT1414282	hsa-miR-4658	CLIP-seq
MIRT1414283	hsa-miR-4665-5p	CLIP-seq
MIRT1414284	hsa-miR-4667-5p	CLIP-seq
MIRT1414285	hsa-miR-4690-3p	CLIP-seq
MIRT1414286	hsa-miR-4700-5p	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT1414288	hsa-miR-4728-5p	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1414290	hsa-miR-520g	CLIP-seq
MIRT1414291	hsa-miR-520h	CLIP-seq
MIRT1414292	hsa-miR-548ah	CLIP-seq
MIRT1414293	hsa-miR-548an	CLIP-seq
MIRT1414294	hsa-miR-574-5p	CLIP-seq
MIRT1414295	hsa-miR-661	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq
MIRT1554480	hsa-miR-148a	CLIP-seq
MIRT1554481	hsa-miR-148b	CLIP-seq
MIRT1554482	hsa-miR-152	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1554483	hsa-miR-3616-3p	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1554484	hsa-miR-4459	CLIP-seq
MIRT1554485	hsa-miR-4688	CLIP-seq
MIRT1554486	hsa-miR-4733-3p	CLIP-seq
MIRT1554487	hsa-miR-4755-3p	CLIP-seq
MIRT1554488	hsa-miR-4761-3p	CLIP-seq
MIRT1554489	hsa-miR-4779	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1554490	hsa-miR-665	CLIP-seq
MIRT2124278	hsa-miR-1286	CLIP-seq
MIRT2124279	hsa-miR-1289	CLIP-seq
MIRT2124280	hsa-miR-1825	CLIP-seq
MIRT2124281	hsa-miR-199a-5p	CLIP-seq
MIRT2124282	hsa-miR-199b-5p	CLIP-seq
MIRT2124283	hsa-miR-28-5p	CLIP-seq
MIRT2124284	hsa-miR-296-3p	CLIP-seq
MIRT2124285	hsa-miR-3139	CLIP-seq
MIRT2124286	hsa-miR-3154	CLIP-seq
MIRT2124287	hsa-miR-3185	CLIP-seq
MIRT2124288	hsa-miR-3190	CLIP-seq
MIRT2124289	hsa-miR-3198	CLIP-seq
MIRT2124290	hsa-miR-3690	CLIP-seq
MIRT2124291	hsa-miR-3909	CLIP-seq
MIRT2124292	hsa-miR-3925-3p	CLIP-seq
MIRT2124293	hsa-miR-3929	CLIP-seq
MIRT2124294	hsa-miR-4254	CLIP-seq
MIRT2124295	hsa-miR-4283	CLIP-seq
MIRT2124296	hsa-miR-4294	CLIP-seq
MIRT2124297	hsa-miR-4309	CLIP-seq
MIRT2124298	hsa-miR-4419b	CLIP-seq
MIRT2124299	hsa-miR-4478	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT2124300	hsa-miR-4722-5p	CLIP-seq
MIRT2124301	hsa-miR-7	CLIP-seq
MIRT2124302	hsa-miR-708	CLIP-seq
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT2346567	hsa-miR-122	CLIP-seq
MIRT2346568	hsa-miR-1912	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT2346569	hsa-miR-3127-3p	CLIP-seq
MIRT2346570	hsa-miR-3160-3p	CLIP-seq
MIRT2346571	hsa-miR-3179	CLIP-seq
MIRT1414262	hsa-miR-3192	CLIP-seq
MIRT2346572	hsa-miR-3202	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT2346573	hsa-miR-3919	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT2346574	hsa-miR-3936	CLIP-seq
MIRT1414272	hsa-miR-4260	CLIP-seq
MIRT2346575	hsa-miR-4329	CLIP-seq
MIRT2346576	hsa-miR-4426	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT2346577	hsa-miR-4647	CLIP-seq
MIRT2346578	hsa-miR-4648	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT2346579	hsa-miR-4654	CLIP-seq
MIRT2346580	hsa-miR-4662b	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT2346581	hsa-miR-4747-5p	CLIP-seq
MIRT2346582	hsa-miR-4756-3p	CLIP-seq
MIRT2346583	hsa-miR-4769-5p	CLIP-seq
MIRT2346584	hsa-miR-4786-5p	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1414294	hsa-miR-574-5p	CLIP-seq
MIRT2346585	hsa-miR-769-5p	CLIP-seq
MIRT2346586	hsa-miR-939	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	14743216, 17568778, 21903422, 21931555, 27980081, 32707033
GO:0005737	Component	Cytoplasm	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	NAS	21931631
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	21931631
GO:1902554	Component	Serine/threonine protein kinase complex	NAS	21931631

Other IDs

• MIM: 608476
• HGNC: 30140
• e!Ensembl: ENSG00000198933

Protein

• UniProt ID: A7MCY6
• Protein name: TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)
• Protein function: Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12845	TBD	288 → 342	TBD domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus. {ECO:0000269|PubMed:17568778}.
• Sequence:

  MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLER
  ENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKN
  KEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAF
  SNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEA
  RGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTE
  LTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPC
  PPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPS
  CPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQ
  AEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTI
  RCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDD
  ALIKHIDSHLENSKI

• Sequence length: 615

Pathways

KEGG:

RIG-I-like receptor signaling pathway