Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9632
Gene name Gene Name - the full gene name approved by the HGNC.
SEC24 homolog C, COPII component
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SEC24C
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible f
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018005 hsa-miR-335-5p Microarray 18185580
MIRT019799 hsa-miR-375 Microarray 20215506
MIRT047285 hsa-miR-181b-5p CLASH 23622248
MIRT046743 hsa-miR-222-3p CLASH 23622248
MIRT039678 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000149 Function SNARE binding IBA 21873635
GO:0000149 Function SNARE binding IPI 18843296
GO:0002474 Process Antigen processing and presentation of peptide antigen via MHC class I TAS
GO:0005515 Function Protein binding IPI 10075675, 15899885, 17428803, 18692470, 25416956, 30842662, 31515488
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607185 10705 ENSG00000176986
Protein
UniProt ID P53992
Protein name Protein transport protein Sec24C (SEC24-related protein C)
Protein function Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicle
PDB 3EH2 , 6PU1 , 8CL3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04810 zf-Sec23_Sec24 422 460 Sec23/Sec24 zinc finger Domain
PF04811 Sec23_trunk 499 743 Sec23/Sec24 trunk domain Domain
PF08033 Sec23_BS 748 832 Sec23/Sec24 beta-sandwich domain Domain
PF04815 Sec23_helical 843 945 Sec23/Sec24 helical domain Domain
PF00626 Gelsolin 961 1036 Gelsolin repeat Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10329445}.
Sequence
MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMS
RAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQ
PPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYG
SYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPS
VSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPY
PAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTN
FLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGES
GPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELS
LGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGA
EESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITS
LLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDD
RKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSV
YKYASFQVENDQERFLSDLRRDV
QKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVEL
AGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCC
TQLADLYR
NCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPEC
MKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNV
FFYPRLLPLTKSPVE
STTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSV
LPVLDNPLSKKVRGLI
DSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVD
FLCHMHKEIRQLLS
Sequence length 1094
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein processing in endoplasmic reticulum
Pathogenic Escherichia coli infection
  COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Atrial septal defect Atrial Septal Defects rs137852951, rs137852953, rs137852955, rs267607106, rs104893900, rs104893901, rs104893903, rs606231358, rs606231359, rs137852683, rs606231360, rs104893907, rs104894073, rs1585703301, rs104894074
View all (25 more)
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs786205019
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
Unknown
Disease term Disease name Evidence References Source
22q11.2 deletion syndrome 22q11.2 deletion syndrome ClinVar, GenCC
Asthma Asthma ClinVar
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease ClinVar
Major affective disorder MAJOR AFFECTIVE DISORDER 2, MAJOR AFFECTIVE DISORDER 1, MAJOR AFFECTIVE DISORDER 4, MAJOR AFFECTIVE DISORDER 6, MAJOR AFFECTIVE DISORDER 7, MAJOR AFFECTIVE DISORDER 8, MAJOR AFFECTIVE DISORDER 9 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Axial Spondyloarthritis Associate 35359923
Bipolar Disorder Associate 22373040
Depressive Disorder Major Associate 22373040
DiGeorge Syndrome Associate 26608785
HIV Infections Associate 36202818
Melanoma Associate 39933900
Neoplasms Associate 34359969