Gene Gene information from NCBI Gene database.
Entrez ID 9632
Gene name SEC24 homolog C, COPII component
Gene symbol SEC24C
Synonyms (NCBI Gene)
-
Chromosome 10
Chromosome location 10q22.2
Summary The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible f
miRNA miRNA information provided by mirtarbase database.
459
miRTarBase ID miRNA Experiments Reference
MIRT018005 hsa-miR-335-5p Microarray 18185580
MIRT019799 hsa-miR-375 Microarray 20215506
MIRT047285 hsa-miR-181b-5p CLASH 23622248
MIRT046743 hsa-miR-222-3p CLASH 23622248
MIRT039678 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000149 Function SNARE binding IBA
GO:0000149 Function SNARE binding IEA
GO:0000149 Function SNARE binding IPI 18843296
GO:0001701 Process In utero embryonic development IEA
GO:0005515 Function Protein binding IPI 10075675, 15899885, 16189514, 17428803, 18692470, 25416956, 30842662, 31515488, 33961781, 35271311
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607185 10705 ENSG00000176986
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P53992
Protein name Protein transport protein Sec24C (SEC24-related protein C)
Protein function Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicle
PDB 3EH2 , 6PU1 , 8CL3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04810 zf-Sec23_Sec24 422 460 Sec23/Sec24 zinc finger Domain
PF04811 Sec23_trunk 499 743 Sec23/Sec24 trunk domain Domain
PF08033 Sec23_BS 748 832 Sec23/Sec24 beta-sandwich domain Domain
PF04815 Sec23_helical 843 945 Sec23/Sec24 helical domain Domain
PF00626 Gelsolin 961 1036 Gelsolin repeat Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10329445}.
Sequence
MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMS
RAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQ
PPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYG
SYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPS
VSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPY
PAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTN
FLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGES
GPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELS
LGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGA
EESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITS
LLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDD
RKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSV
YKYASFQVENDQERFLSDLRRDV
QKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVEL
AGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCC
TQLADLYR
NCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPEC
MKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNV
FFYPRLLPLTKSPVE
STTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSV
LPVLDNPLSKKVRGLI
DSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVD
FLCHMHKEIRQLLS
Sequence length 1094
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum
Pathogenic Escherichia coli infection
  COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malignant tumor of urinary bladder Uncertain significance rs750494009 RCV005932402
Microcephaly Uncertain significance rs200016285 RCV001252937
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Axial Spondyloarthritis Associate 35359923
Bipolar Disorder Associate 22373040
Depressive Disorder Major Associate 22373040
DiGeorge Syndrome Associate 26608785
HIV Infections Associate 36202818
Melanoma Associate 39933900
Neoplasms Associate 34359969