Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9630
Gene name Gene Name - the full gene name approved by the HGNC.
G protein subunit alpha 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GNA14
Synonyms (NCBI Gene) Gene synonyms aliases
HG1I
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1554685903 T>A Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018573 hsa-miR-335-5p Microarray 18185580
MIRT610988 hsa-miR-8485 HITS-CLIP 23824327
MIRT610987 hsa-miR-329-3p HITS-CLIP 23824327
MIRT610986 hsa-miR-362-3p HITS-CLIP 23824327
MIRT610985 hsa-miR-603 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001508 Process Action potential IBA
GO:0001664 Function G protein-coupled receptor binding IBA
GO:0001664 Function G protein-coupled receptor binding IEA
GO:0003924 Function GTPase activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604397 4382 ENSG00000156049
Protein
UniProt ID O95837
Protein name Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14)
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha 11 344 G-protein alpha subunit Domain
Sequence
Sequence length 355
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Calcium signaling pathway
Hormone signaling
Chagas disease
Amoebiasis
  Acetylcholine regulates insulin secretion
G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Thrombin signalling through proteinase activated receptors (PARs)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Bipolar Disorder Bipolar disorder N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Inhibit 34657150
Carcinoma Hepatocellular Associate 35800238
Endometrial Neoplasms Associate 30054423
Epilepsy Temporal Lobe Associate 16060937
Hemangioma Associate 31189994
Hypertension Associate 24423937, 30387149
Kasabach Merritt Syndrome Associate 31423605
Mouth Diseases Associate 27476652
Neoplasms Associate 27476652, 30387149, 31189994, 31423605
Neoplasms Stimulate 32235007