CD53 (CD53 molecule)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 963
Gene name CD53 molecule
Gene symbol CD53
Synonyms (NCBI Gene)
MOX44TSPAN25
Chromosome 1
Chromosome location 1p13.3
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
miRNA miRNA information provided by mirtarbase database.
9
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (9)
miRTarBase ID miRNA Experiments Reference
MIRT875813 hsa-miR-1264 CLIP-seq
MIRT875814 hsa-miR-361-5p CLIP-seq
MIRT875815 hsa-miR-4318 CLIP-seq
MIRT875816 hsa-miR-4679 CLIP-seq
MIRT875817 hsa-miR-4693-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0001772 Component Immunological synapse IDA 21930792
GO:0005515 Function Protein binding IPI 21930792, 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 28487417
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
151525 1686 ENSG00000143119
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P19397
Protein name Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
Protein function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:28487417). Participates thereby in diverse biological functions su
PDB 6WVG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 9 → 209 Tetraspanin family Family
Tissue specificity TISSUE SPECIFICITY: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells. {ECO:0000269|PubMed:8335905}.
Sequence
Sequence length 219
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs753040532 RCV005939104
Show/Hide Text Mining Associations (22)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Atherosclerosis Associate 32821283, 34122426
Carcinoma Hepatocellular Associate 37889536
Cardiomyopathy Dilated Associate 36725968
Carotid Artery Diseases Associate 34140767
Cell Transformation Neoplastic Associate 3080434
Chronic Periodontitis Associate 30922293
Communicable Diseases Associate 9067662
Diabetic Nephropathies Associate 35909518, 36154667
Enteritis Associate 27347722
Immunologic Deficiency Syndromes Inhibit 9067662