Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9592
Gene name Gene Name - the full gene name approved by the HGNC.
Immediate early response 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IER2
Synonyms (NCBI Gene) Gene synonyms aliases
CHX1, ETR101
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT040855 hsa-miR-18a-3p CLASH 23622248
MIRT399356 hsa-miR-548ae-3p PAR-CLIP 23592263
MIRT399357 hsa-miR-548ah-3p PAR-CLIP 23592263
MIRT399358 hsa-miR-548aj-3p PAR-CLIP 23592263
MIRT399359 hsa-miR-548am-3p PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IDA 22120713
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IDA 22120713
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
620036 28871 ENSG00000160888
Protein
UniProt ID Q9BTL4
Protein name Immediate early response gene 2 protein (Protein ETR101)
Protein function DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05760 IER 1 203 Immediate early response protein (IER) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713). {ECO:0000269|PubMed:22120713}.
Sequence
Sequence length 223
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 27935865
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 37259023
Colorectal Neoplasms Associate 34311674
Infections Stimulate 11665982
Leukemia Associate 2061303
Stomach Neoplasms Associate 36033825