Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9575
Gene name Gene Name - the full gene name approved by the HGNC.
Clock circadian regulator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CLOCK
Synonyms (NCBI Gene) Gene synonyms aliases
KAT13D, bHLHe8
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002951 hsa-miR-141-3p Northern blot, qRT-PCR, Western blot 16762633
MIRT005358 hsa-miR-182-5p Luciferase reporter assay, qRT-PCR 20656788
MIRT002951 hsa-miR-141-3p Luciferase reporter assay 15131085
MIRT020471 hsa-miR-106b-5p Microarray 17242205
MIRT021546 hsa-miR-142-3p Microarray 17612493
Transcription factors
Transcription factor Regulation Reference
KAT2B Unknown 14645221
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint IMP 21659603
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 18411297
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601851 2082 ENSG00000134852
Protein
UniProt ID O15516
Protein name Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)
Protein function Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g
PDB 4H10 , 6QPJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 35 85 Helix-loop-helix DNA-binding domain Domain
PF00989 PAS 109 188 PAS fold Domain
PF14598 PAS_11 273 381 Domain
Tissue specificity TISSUE SPECIFICITY: Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High
Sequence
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSM
LPGNARKMDKSTVLQKSIDFLRKHK
EITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDG
FFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSK
NQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRT
HRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYL
PFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEV
RAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEA
LERFDHSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSF
SSQSINSQSVGSSLTQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEAN
IHRQQEELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQ
VVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAP
LYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVAC
GAVMVPSTMLMGQVVTAYPTFATQQQQSQTLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQ
PPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPQSHHQQHQSQQQQQLSRHRTDSLPDP
SKVQPQ
Sequence length 846
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Circadian rhythm
Dopaminergic synapse
  BMAL1:CLOCK,NPAS2 activates circadian gene expression
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
20364331
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder 23516567, 22826347, 22535308, 25522426, 24673294, 24001941, 23273899, 24581835, 25135782, 25349171 ClinVar
Coronary artery disease Coronary artery disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abidi X linked mental retardation syndrome Associate 35961261
Acute Phase Reaction Inhibit 26370682
Aging Premature Associate 35069971
Alzheimer Disease Associate 23781009, 32348224, 33114015
Asthenozoospermia Associate 35000095
Asthma Associate 37108640
Atherosclerosis Associate 24418196
Atrophy Associate 36130474
Attention Deficit and Disruptive Behavior Disorders Associate 31708917
Attention Deficit Disorder with Hyperactivity Associate 20704703, 30696097, 30758328, 32538895, 34273025