Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
957
Gene name Gene Name - the full gene name approved by the HGNC.
Ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ENTPD5
Synonyms (NCBI Gene) Gene synonyms aliases
CD39L4, NTPDase-5, PCPH
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [pr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT614197 hsa-miR-329-5p HITS-CLIP 23824327
MIRT614196 hsa-miR-6817-3p HITS-CLIP 23824327
MIRT614195 hsa-miR-130b-5p HITS-CLIP 23824327
MIRT614194 hsa-miR-6873-3p HITS-CLIP 23824327
MIRT614193 hsa-miR-4753-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004382 Function GDP phosphatase activity IDA 10400613, 15698960
GO:0004382 Function GDP phosphatase activity IEA
GO:0004382 Function GDP phosphatase activity ISS
GO:0005515 Function Protein binding IPI 25416956, 32814053
GO:0005576 Component Extracellular region IDA 15698960
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603162 3367 ENSG00000187097
Protein
UniProt ID O75356
Protein name Nucleoside diphosphate phosphatase ENTPD5 (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Ectonucleoside triphosphate diphosphohydrolase 5) (NTPDase 5) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Inosine diphosphate phosphatase ENTPD5) (Nucleoside d
Protein function Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01150 GDA1_CD39 41 427 GDA1/CD39 (nucleoside phosphatase) family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. {ECO:0000269|PubMed:9676430}.
Sequence
Sequence length 428
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Purine metabolism
Pyrimidine metabolism
Metabolic pathways
Nucleotide metabolism
  Phosphate bond hydrolysis by NTPDase proteins
Purinergic signaling in leishmaniasis infection
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