Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9567
Gene name Gene Name - the full gene name approved by the HGNC.
GTP binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GTPBP1
Synonyms (NCBI Gene) Gene synonyms aliases
GP-1, GP1, HSPC018, NEDFET1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDFET1
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027163 hsa-miR-103a-3p Sequencing 20371350
MIRT031922 hsa-miR-16-5p Sequencing 20371350
MIRT048537 hsa-miR-100-5p CLASH 23622248
MIRT043448 hsa-miR-331-3p CLASH 23622248
MIRT041906 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000177 Component Cytoplasmic exosome (RNase complex) ISS
GO:0003723 Function RNA binding HDA 22658674
GO:0003746 Function Translation elongation factor activity IBA 21873635
GO:0003924 Function GTPase activity ISS
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602245 4669 ENSG00000100226
Protein
UniProt ID O00178
Protein name GTP-binding protein 1 (G-protein 1) (GP-1) (GP1)
Protein function Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00009 GTP_EFTU 160 385 Elongation factor Tu GTP binding domain Domain
Sequence
MATERSRSAMDSPVPASMFAPEPSSPGAARAAAAAARLHGGFDSDCSEDGEALNGEPELD
LTSKLVLVSPTSEQYDSLLRQMWERMDEGCGETIYVIGQGSDGTEYGLSEADMEASYATV
KSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVL
THGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKI
CEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALN
VPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMC
PIFQISNVTGENLDLLKMFLNLLSP
RTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGL
IKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMV
SPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATV
HFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLT
KRDEGGPSGGPAVGAPPPGDEASSVGAGQPAASSNLQPQPKPSSGGRRRGGQRHKVKSQG
ACVTPASGC
Sequence length 669
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
23587638
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Associate 35440542
Infections Associate 29029641
Leukemia Lymphoma Adult T Cell Associate 35041720
Neoplasm Metastasis Stimulate 35440542