H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9563 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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H6PD |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CORTRD1, G6PDH, GDH, H6PDH |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p36.22 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | O95479 | ||||||||||||||||||||
| Protein name | GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] | ||||||||||||||||||||
| Protein function | Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and meta | ||||||||||||||||||||
| PDB | 8EM2 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Present in most tissues examined, strongest in liver. {ECO:0000269|PubMed:10349511}. | ||||||||||||||||||||
| Sequence | |||||||||||||||||||||
| Sequence length | 791 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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