Gene Gene information from NCBI Gene database.
Entrez ID 955
Gene name Ectonucleoside triphosphate diphosphohydrolase 6
Gene symbol ENTPD6
Synonyms (NCBI Gene)
CD39L2IL-6SAGIL6ST2NTPDase-6dJ738P15.3
Chromosome 20
Chromosome location 20p11.21
Summary ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcri
miRNA miRNA information provided by mirtarbase database.
422
miRTarBase ID miRNA Experiments Reference
MIRT025838 hsa-miR-7-5p Microarray 19073608
MIRT052035 hsa-let-7b-5p CLASH 23622248
MIRT040090 hsa-miR-615-3p CLASH 23622248
MIRT035763 hsa-miR-365a-5p CLASH 23622248
MIRT152503 hsa-miR-15a-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0004382 Function GDP phosphatase activity IDA 14529283
GO:0004382 Function GDP phosphatase activity IEA
GO:0005576 Component Extracellular region IDA 11041856
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603160 3368 ENSG00000197586
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75354
Protein name Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)
Protein function Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01150 GDA1_CD39 93 483 GDA1/CD39 (nucleoside phosphatase) family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues, but predominantly in heart. {ECO:0000269|PubMed:11041856}.
Sequence
Sequence length 484
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Purine metabolism
Pyrimidine metabolism
Metabolic pathways
Nucleotide metabolism
  Phosphate bond hydrolysis by NTPDase proteins