Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
955
Gene name Gene Name - the full gene name approved by the HGNC.
Ectonucleoside triphosphate diphosphohydrolase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ENTPD6
Synonyms (NCBI Gene) Gene synonyms aliases
CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p11.21
Summary Summary of gene provided in NCBI Entrez Gene.
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcri
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025838 hsa-miR-7-5p Microarray 19073608
MIRT052035 hsa-let-7b-5p CLASH 23622248
MIRT040090 hsa-miR-615-3p CLASH 23622248
MIRT035763 hsa-miR-365a-5p CLASH 23622248
MIRT152503 hsa-miR-15a-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0004382 Function Guanosine-diphosphatase activity IBA 21873635
GO:0004382 Function Guanosine-diphosphatase activity IDA 14529283
GO:0005576 Component Extracellular region IDA 11041856
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603160 3368 ENSG00000197586
Protein
UniProt ID O75354
Protein name Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)
Protein function Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01150 GDA1_CD39 93 483 GDA1/CD39 (nucleoside phosphatase) family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues, but predominantly in heart. {ECO:0000269|PubMed:11041856}.
Sequence
Sequence length 484
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Purine metabolism
Pyrimidine metabolism
Metabolic pathways
Nucleotide metabolism
  Phosphate bond hydrolysis by NTPDase proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
29273807
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
COVID 19 Associate 37020555
Infertility Male Associate 37020555
Neoplasms Associate 36110123