Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9525
Gene name Gene Name - the full gene name approved by the HGNC.
Vacuolar protein sorting 4 homolog B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VPS4B
Synonyms (NCBI Gene) Gene synonyms aliases
MIG1, SKD1, SKD1B, VPS4-2
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020843 hsa-miR-155-5p Proteomics 18668040
MIRT022010 hsa-miR-128-3p Sequencing 20371350
MIRT022778 hsa-miR-124-3p Microarray 18668037
MIRT028319 hsa-miR-32-5p Sequencing 20371350
MIRT031206 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000922 Component Spindle pole IDA 20616062
GO:0005515 Function Protein binding IPI 11563910, 14505570, 16193069, 16757520, 17928862, 18385515, 18687924, 19129479, 23105106, 25416956, 31515488, 32296183, 32814053
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 16757520, 20616062
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609983 10895 ENSG00000119541
Protein
UniProt ID O75351
Protein name Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)
Protein function Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redi
PDB 1WR0 , 1XWI , 2CPT , 2JQH , 2JQK , 4U7Y , 7L9X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04212 MIT 8 74 MIT (microtubule interacting and transport) domain Domain
PF00004 AAA 170 300 ATPase family associated with various cellular activities (AAA) Domain
PF17862 AAA_lid_3 323 364 AAA+ lid domain Domain
PF09336 Vps4_C 381 441 Vps4 C terminal oligomerisation domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11563910}.
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1
Virion - Hepatitis viruses
Endocytosis
Necroptosis
  Budding and maturation of HIV virion
Endosomal Sorting Complex Required For Transport (ESCRT)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Dentin Dysplasia dentin dysplasia type I GenCC
Associations from Text Mining
Disease Name Relationship Type References
Dentin dysplasia type 1 Associate 32737282
Tuberculosis Multidrug Resistant Associate 25333456
Uterine Cervical Neoplasms Associate 32806782