Gene Gene information from NCBI Gene database.
Entrez ID 9525
Gene name Vacuolar protein sorting 4 homolog B
Gene symbol VPS4B
Synonyms (NCBI Gene)
MIG1SKD1SKD1BVPS4-2
Chromosome 18
Chromosome location 18q21.33
Summary The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share
miRNA miRNA information provided by mirtarbase database.
464
miRTarBase ID miRNA Experiments Reference
MIRT020843 hsa-miR-155-5p Proteomics 18668040
MIRT022010 hsa-miR-128-3p Sequencing 20371350
MIRT022778 hsa-miR-124-3p Microarray 18668037
MIRT028319 hsa-miR-32-5p Sequencing 20371350
MIRT031206 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
91
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000922 Component Spindle pole IDA 20616062
GO:0000922 Component Spindle pole IEA
GO:0001525 Process Angiogenesis IEA
GO:0001778 Process Plasma membrane repair NAS 24482116
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609983 10895 ENSG00000119541
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75351
Protein name Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)
Protein function Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redi
PDB 1WR0 , 1XWI , 2CPT , 2JQH , 2JQK , 4U7Y , 7L9X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04212 MIT 8 74 MIT (microtubule interacting and transport) domain Domain
PF00004 AAA 170 300 ATPase family associated with various cellular activities (AAA) Domain
PF17862 AAA_lid_3 323 364 AAA+ lid domain Domain
PF09336 Vps4_C 381 441 Vps4 C terminal oligomerisation domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11563910}.
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Viral life cycle - HIV-1
Virion - Hepatitis viruses
Endocytosis
Necroptosis
  Budding and maturation of HIV virion
Endosomal Sorting Complex Required For Transport (ESCRT)