RPH3AL (rabphilin 3A like (without C2 domains))

Gene

• Entrez ID: 9501
• Gene name: Rabphilin 3A like (without C2 domains)
• Gene symbol: RPH3AL
• Synonyms (NCBI Gene): NOC2
• Chromosome: 17
• Chromosome location: 17p13.3
• Summary: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative spl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018406	hsa-miR-335-5p	Microarray	18185580
MIRT051146	hsa-miR-16-5p	CLASH	23622248
MIRT647348	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT647347	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT647346	hsa-miR-615-5p	HITS-CLIP	23824327
MIRT647345	hsa-miR-7704	HITS-CLIP	23824327
MIRT647344	hsa-miR-5100	HITS-CLIP	23824327
MIRT647343	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT647342	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT647341	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT647340	hsa-miR-3170	HITS-CLIP	23824327
MIRT647339	hsa-miR-6855-5p	HITS-CLIP	23824327
MIRT647338	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT647337	hsa-miR-5572	HITS-CLIP	23824327
MIRT647336	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT647335	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT647334	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT647333	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT647332	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT647331	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT647330	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT647329	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT647328	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT647327	hsa-miR-940	HITS-CLIP	23824327
MIRT647326	hsa-miR-3929	HITS-CLIP	23824327
MIRT647325	hsa-miR-4419b	HITS-CLIP	23824327
MIRT647324	hsa-miR-4478	HITS-CLIP	23824327
MIRT647323	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT647322	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT647321	hsa-miR-5690	HITS-CLIP	23824327
MIRT647320	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT647319	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT647318	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT647317	hsa-miR-1827	HITS-CLIP	23824327
MIRT647316	hsa-miR-3975	HITS-CLIP	23824327
MIRT647315	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT647314	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT647313	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT647312	hsa-miR-3188	HITS-CLIP	23824327
MIRT647311	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT647310	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT647309	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT647308	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT647307	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT647306	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT647305	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT647304	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT647303	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT647302	hsa-miR-3689c	HITS-CLIP	23824327
MIRT647301	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT647300	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT647299	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT489206	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT489205	hsa-miR-1226-3p	PAR-CLIP	23592263
MIRT489204	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT489202	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT489203	hsa-miR-544b	PAR-CLIP	23592263
MIRT489201	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT489200	hsa-miR-492	PAR-CLIP	23592263
MIRT489199	hsa-miR-3649	PAR-CLIP	23592263
MIRT489198	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489197	hsa-miR-8085	PAR-CLIP	23592263
MIRT489196	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT647326	hsa-miR-3929	PAR-CLIP	27292025
MIRT647325	hsa-miR-4419b	PAR-CLIP	27292025
MIRT647324	hsa-miR-4478	PAR-CLIP	27292025
MIRT647320	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT647314	hsa-miR-485-5p	PAR-CLIP	27292025
MIRT489201	hsa-miR-6746-5p	PAR-CLIP	27292025
MIRT647313	hsa-miR-6884-5p	PAR-CLIP	27292025
MIRT647348	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT647347	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT647346	hsa-miR-615-5p	HITS-CLIP	23824327
MIRT647345	hsa-miR-7704	HITS-CLIP	23824327
MIRT647344	hsa-miR-5100	HITS-CLIP	23824327
MIRT647343	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT647342	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT647341	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT647340	hsa-miR-3170	HITS-CLIP	23824327
MIRT647339	hsa-miR-6855-5p	HITS-CLIP	23824327
MIRT647338	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT647337	hsa-miR-5572	HITS-CLIP	23824327
MIRT647336	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT647335	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT647334	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT647333	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT647332	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT647331	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT647330	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT647329	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT647328	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT647327	hsa-miR-940	HITS-CLIP	23824327
MIRT647326	hsa-miR-3929	HITS-CLIP	23824327
MIRT647325	hsa-miR-4419b	HITS-CLIP	23824327
MIRT647324	hsa-miR-4478	HITS-CLIP	23824327
MIRT647323	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT647322	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT647321	hsa-miR-5690	HITS-CLIP	23824327
MIRT647320	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT647319	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT647318	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT647317	hsa-miR-1827	HITS-CLIP	23824327
MIRT647316	hsa-miR-3975	HITS-CLIP	23824327
MIRT647315	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT647314	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT647313	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT647312	hsa-miR-3188	HITS-CLIP	23824327
MIRT647311	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT647310	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT647309	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT647308	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT647307	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT647306	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT647305	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT647304	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT647303	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT647302	hsa-miR-3689c	HITS-CLIP	23824327
MIRT647301	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT647300	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT647299	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT489206	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT489205	hsa-miR-1226-3p	PAR-CLIP	23592263
MIRT489204	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT489202	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT489203	hsa-miR-544b	PAR-CLIP	23592263
MIRT489201	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT489200	hsa-miR-492	PAR-CLIP	23592263
MIRT489199	hsa-miR-3649	PAR-CLIP	23592263
MIRT489198	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489197	hsa-miR-8085	PAR-CLIP	23592263
MIRT489196	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT1315722	hsa-miR-1202	CLIP-seq
MIRT1315723	hsa-miR-1257	CLIP-seq
MIRT1315724	hsa-miR-1262	CLIP-seq
MIRT1315725	hsa-miR-15a	CLIP-seq
MIRT1315726	hsa-miR-15b	CLIP-seq
MIRT1315727	hsa-miR-16	CLIP-seq
MIRT1315728	hsa-miR-195	CLIP-seq
MIRT1315729	hsa-miR-3194-5p	CLIP-seq
MIRT1315730	hsa-miR-3609	CLIP-seq
MIRT1315731	hsa-miR-3972	CLIP-seq
MIRT1315732	hsa-miR-424	CLIP-seq
MIRT1315733	hsa-miR-4419a	CLIP-seq
MIRT1315734	hsa-miR-4447	CLIP-seq
MIRT1315735	hsa-miR-4472	CLIP-seq
MIRT1315736	hsa-miR-4488	CLIP-seq
MIRT1315737	hsa-miR-4510	CLIP-seq
MIRT1315738	hsa-miR-452	CLIP-seq
MIRT1315739	hsa-miR-4530	CLIP-seq
MIRT1315740	hsa-miR-4676-3p	CLIP-seq
MIRT1315741	hsa-miR-4693-5p	CLIP-seq
MIRT1315742	hsa-miR-4697-5p	CLIP-seq
MIRT1315743	hsa-miR-4701-3p	CLIP-seq
MIRT1315744	hsa-miR-4776-3p	CLIP-seq
MIRT1315745	hsa-miR-4790-3p	CLIP-seq
MIRT1315746	hsa-miR-497	CLIP-seq
MIRT1315747	hsa-miR-541	CLIP-seq
MIRT1315748	hsa-miR-548ah	CLIP-seq
MIRT1315749	hsa-miR-548t	CLIP-seq
MIRT1315750	hsa-miR-654-5p	CLIP-seq
MIRT1315751	hsa-miR-1225-3p	CLIP-seq
MIRT1315752	hsa-miR-1227	CLIP-seq
MIRT1315753	hsa-miR-1233	CLIP-seq
MIRT1315754	hsa-miR-217	CLIP-seq
MIRT1315755	hsa-miR-299-3p	CLIP-seq
MIRT1315756	hsa-miR-3064-3p	CLIP-seq
MIRT1315757	hsa-miR-3117-5p	CLIP-seq
MIRT1315758	hsa-miR-3123	CLIP-seq
MIRT1315759	hsa-miR-3153	CLIP-seq
MIRT1315760	hsa-miR-3174	CLIP-seq
MIRT1315730	hsa-miR-3609	CLIP-seq
MIRT1315761	hsa-miR-3660	CLIP-seq
MIRT1315762	hsa-miR-3689d	CLIP-seq
MIRT1315763	hsa-miR-3940-3p	CLIP-seq
MIRT1315764	hsa-miR-4252	CLIP-seq
MIRT1315738	hsa-miR-452	CLIP-seq
MIRT1315765	hsa-miR-4526	CLIP-seq
MIRT1315766	hsa-miR-4537	CLIP-seq
MIRT1315767	hsa-miR-4648	CLIP-seq
MIRT1315768	hsa-miR-4654	CLIP-seq
MIRT1315769	hsa-miR-4668-5p	CLIP-seq
MIRT1315740	hsa-miR-4676-3p	CLIP-seq
MIRT1315741	hsa-miR-4693-5p	CLIP-seq
MIRT1315770	hsa-miR-4749-3p	CLIP-seq
MIRT1315771	hsa-miR-4769-5p	CLIP-seq
MIRT1315748	hsa-miR-548ah	CLIP-seq
MIRT1315751	hsa-miR-1225-3p	CLIP-seq
MIRT1315753	hsa-miR-1233	CLIP-seq
MIRT1315762	hsa-miR-3689d	CLIP-seq
MIRT1315763	hsa-miR-3940-3p	CLIP-seq
MIRT1315766	hsa-miR-4537	CLIP-seq
MIRT2093911	hsa-miR-3936	CLIP-seq
MIRT2093912	hsa-miR-4521	CLIP-seq
MIRT1315758	hsa-miR-3123	CLIP-seq
MIRT2318412	hsa-miR-3180-5p	CLIP-seq
MIRT2318413	hsa-miR-520a-5p	CLIP-seq
MIRT2318414	hsa-miR-525-5p	CLIP-seq
MIRT1315759	hsa-miR-3153	CLIP-seq
MIRT1315760	hsa-miR-3174	CLIP-seq
MIRT1315730	hsa-miR-3609	CLIP-seq
MIRT1315738	hsa-miR-452	CLIP-seq
MIRT1315740	hsa-miR-4676-3p	CLIP-seq
MIRT1315741	hsa-miR-4693-5p	CLIP-seq
MIRT1315748	hsa-miR-548ah	CLIP-seq
MIRT2458551	hsa-miR-1228	CLIP-seq
MIRT2458552	hsa-miR-3122	CLIP-seq
MIRT2458553	hsa-miR-3672	CLIP-seq
MIRT2458554	hsa-miR-3913-5p	CLIP-seq
MIRT2458555	hsa-miR-4691-5p	CLIP-seq
MIRT2458556	hsa-miR-4728-5p	CLIP-seq
MIRT2458557	hsa-miR-4786-5p	CLIP-seq
MIRT2458558	hsa-miR-769-5p	CLIP-seq
MIRT2458551	hsa-miR-1228	CLIP-seq
MIRT2614223	hsa-miR-1236	CLIP-seq
MIRT2458552	hsa-miR-3122	CLIP-seq
MIRT2458553	hsa-miR-3672	CLIP-seq
MIRT2458554	hsa-miR-3913-5p	CLIP-seq
MIRT2458556	hsa-miR-4728-5p	CLIP-seq
MIRT2458557	hsa-miR-4786-5p	CLIP-seq
MIRT2614224	hsa-miR-4799-5p	CLIP-seq
MIRT2614225	hsa-miR-548c-3p	CLIP-seq
MIRT2458558	hsa-miR-769-5p	CLIP-seq
MIRT2458551	hsa-miR-1228	CLIP-seq
MIRT2614223	hsa-miR-1236	CLIP-seq
MIRT2458552	hsa-miR-3122	CLIP-seq
MIRT2458553	hsa-miR-3672	CLIP-seq
MIRT2458554	hsa-miR-3913-5p	CLIP-seq
MIRT2458556	hsa-miR-4728-5p	CLIP-seq
MIRT2458557	hsa-miR-4786-5p	CLIP-seq
MIRT2614224	hsa-miR-4799-5p	CLIP-seq
MIRT2614225	hsa-miR-548c-3p	CLIP-seq
MIRT2458558	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9367993
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006887	Process	Exocytosis	IEA
GO:0006887	Process	Exocytosis	TAS	9367993
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0008092	Function	Cytoskeletal protein binding	TAS	9367993
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0045202	Component	Synapse	IBA
GO:0045744	Process	Negative regulation of G protein-coupled receptor signaling pathway	IEA
GO:0045956	Process	Positive regulation of calcium ion-dependent exocytosis	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0098793	Component	Presynapse	IEA
GO:0099502	Process	Calcium-dependent activation of synaptic vesicle fusion	IBA

Other IDs

• MIM: 604881
• HGNC: 10296
• e!Ensembl: ENSG00000181031

Protein

• UniProt ID: Q9UNE2
• Protein name: Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)
• Protein function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02318	FYVE_2	45 → 159	FYVE-type zinc finger	Family

• Tissue specificity: TISSUE SPECIFICITY: Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells. {ECO:0000269|PubMed:10395805, ECO:0000269|PubMed:15003533}.
• Sequence:

  MADTIFGSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRKQHLSPAEVEAILQVIQ
  RAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVC
  TKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPL
  PTEPAEREPRSSETSRIYTWARGRVVSSDSDSDSDLSSSSLEDRLPSTGVRDRKGDKPWK
  ESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGGPRPGLTRRAPVKDTPGRA
  PAADAAPAGPSSCLG

• Sequence length: 315