Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9500
Gene name Gene Name - the full gene name approved by the HGNC.	MAGE family member D1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAGED1
Synonyms (NCBI Gene) Gene synonyms aliases	DLXIN-1, NRAGE
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp11.22
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homolog

Show/Hide all(187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042443	hsa-miR-424-5p	CLASH	23622248
MIRT040341	hsa-miR-615-3p	CLASH	23622248
MIRT038660	hsa-let-7g-3p	CLASH	23622248
MIRT036791	hsa-miR-760	CLASH	23622248
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT1125738	hsa-miR-3200-5p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125745	hsa-miR-513a-3p	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT2035515	hsa-miR-2467-5p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT2035517	hsa-miR-3157-5p	CLIP-seq
MIRT2035518	hsa-miR-3188	CLIP-seq
MIRT1125738	hsa-miR-3200-5p	CLIP-seq
MIRT2035519	hsa-miR-342-3p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT2035520	hsa-miR-3975	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035521	hsa-miR-450b-5p	CLIP-seq
MIRT2035522	hsa-miR-4649-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT2035524	hsa-miR-4762-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT2035525	hsa-miR-485-5p	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT2035519	hsa-miR-342-3p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT2035524	hsa-miR-4762-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125745	hsa-miR-513a-3p	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT2035515	hsa-miR-2467-5p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT2035518	hsa-miR-3188	CLIP-seq
MIRT1125738	hsa-miR-3200-5p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT2035520	hsa-miR-3975	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035522	hsa-miR-4649-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT2035525	hsa-miR-485-5p	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125745	hsa-miR-513a-3p	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISS
GO:0005515	Function	Protein binding	IPI	15930293, 16000308, 20864041, 21516116, 24722188, 25416956, 25910212, 26871637, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006355	Process	Regulation of transcription, DNA-templated	TAS	15930293
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0032991	Component	Protein-containing complex	IDA	15930293
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0042981	Process	Regulation of apoptotic process	TAS	15930293
GO:0050680	Process	Negative regulation of epithelial cell proliferation	IDA	15930293

MIM	HGNC	e!Ensembl
300224	6813	ENSG00000179222

Protein

UniProt ID

Q9Y5V3

Protein name

Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)

Protein function

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubi

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01454	MAGE	478 → 645	MAGE family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.

Sequence

MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTAN
EMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPK
GPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTP
FKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLES
RTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPL
AWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPI
VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPT
DWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVK
YLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYIL
ISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLL
GDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPR
DWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEE
GDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE

Sequence length

778

Interactions

View interactions

	KEGG
	Neurotrophin signaling pathway

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	18264097

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Inhibit	15930293
Breast Neoplasms	Associate	22935435
Carcinogenesis	Associate	15930293
Carcinogenesis	Inhibit	22935435
Carcinoma Hepatocellular	Associate	32941982
Carcinoma Non Small Cell Lung	Associate	28639909
Carcinoma Renal Cell	Associate	16082191
Carotid Body Tumor	Associate	30967136
Cocaine Related Disorders	Associate	38123574
Colorectal Neoplasms	Inhibit	22935435
Developmental Disabilities	Associate	28414775
Esophageal Neoplasms	Associate	20868560, 26738870, 29516958
Esophageal Squamous Cell Carcinoma	Associate	26738870
Esophagitis	Associate	20868560
Glioma	Associate	22935435
Hypoxia	Associate	17453828
Intellectual Disability	Associate	28414775
Joint Instability	Associate	28414775
Leukemia Myeloid Acute	Associate	37635487
Lung Neoplasms	Associate	28639909
Lymphoproliferative Syndrome X Linked 2	Associate	28414775
Megalencephaly	Associate	28414775
Multiple Myeloma	Associate	33338886
Muscle Hypotonia	Associate	28414775
Neoplasms	Inhibit	17453828, 29516958
Neoplasms	Associate	21765901, 23884293, 28639909, 37635487
Root Resorption	Associate	38546524
Sarcoma	Associate	34307667

MAGED1 (MAGE family member D1)