Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
94241
Gene name Gene Name - the full gene name approved by the HGNC.
Tumor protein p53 inducible nuclear protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TP53INP1
Synonyms (NCBI Gene) Gene synonyms aliases
SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q22.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003007 hsa-miR-155-5p Western blot, Luciferase reporter assay 17911264
MIRT003007 hsa-miR-155-5p Luciferase reporter assay 17911264
MIRT000021 hsa-miR-93-5p Luciferase reporter assay, Western blot 18974142
MIRT000021 hsa-miR-93-5p Luciferase reporter assay, Western blot 18974142
MIRT000335 hsa-miR-130b-3p Luciferase reporter assay, Western blot 18974142
Transcription factors
Transcription factor Regulation Reference
E2F1 Activation 15706352
MYCN Repression 17495526
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA 21873635
GO:0005515 Function Protein binding IPI 22421968, 22470510, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 22470510
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606185 18022 ENSG00000164938
Protein
UniProt ID Q96A56
Protein name Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)
Protein function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relo
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14839 DOR 24 236 DOR family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:12067065}.
Sequence
Sequence length 240
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Regulation of TP53 Activity through Phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
23300278, 20581827, 30595370, 21647700
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 24922517, 33712570
Bone Neoplasms Associate 30592172
Breast Neoplasms Associate 17201159, 24152184, 28791367, 29329575, 30015868, 35617355, 36755123
Breast Neoplasms Inhibit 22051041
Carcinoma Hepatocellular Associate 25601564
Carcinoma Non Small Cell Lung Associate 32432745
Carcinoma Ovarian Epithelial Associate 10072171
Carcinoma Pancreatic Ductal Associate 24608790
Cataract Stimulate 31281592
Cataract Age Related Nuclear Stimulate 31281592